Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells

doi:10.1111/jphp.12298

Residential College	false
Status	已發表Published
	Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells
	Kamato D.; Rostam M.A.; Piva T.J.; Babaahmadi Rezaei H.; Getachew R.; Thach L.; Bernard R.; Zheng W.; Little P.J.; Osman N.
	2014-12-01
Source Publication	The Journal of pharmacy and pharmacology
ISSN	20427158
Volume	66 Issue:12 Pages:1722-1733
Abstract	OBJECTIVES: Transforming growth factor (TGF)-β regulates the function of vascular endothelial cells and may be involved in endothelial dysfunction. The canonical TGF-β pathway involves TGF-β receptor-mediated carboxy-terminal phosphorylation of Smad2; however, TGF-β signalling also activates numerous serine/threonine kinases that phosphorylate Smad2 in its linker region. The expression of phosphorylated Smad linker proteins were determined following TGF-β stimulation in the absence and presence of different serine/threonine kinase inhibitors in vascular endothelial cells.
Keyword	Cell Signalling Serine/threonine Kinase Smad Linker Region Smads Transforming Growth Factor-β
DOI	10.1111/jphp.12298
URL	View the original
Language	英語English
WOS ID	WOS:000345312800007
Scopus ID	2-s2.0-84910597087
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	University of Macau
Affiliation	RMIT University
Recommended Citation GB/T 7714	Kamato D.,Rostam M.A.,Piva T.J.,et al. Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells[J]. The Journal of pharmacy and pharmacology, 2014, 66(12), 1722-1733.
APA	Kamato D.., Rostam M.A.., Piva T.J.., Babaahmadi Rezaei H.., Getachew R.., Thach L.., Bernard R.., Zheng W.., Little P.J.., & Osman N. (2014). Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells. The Journal of pharmacy and pharmacology, 66(12), 1722-1733.
MLA	Kamato D.,et al."Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells".The Journal of pharmacy and pharmacology 66.12(2014):1722-1733.

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