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Comparative comprehension on the anti-rheumatic Chinese herbal medicine Siegesbeckiae Herba: Combined computational predictions and experimental investigations
Zhang Q.R.1,4; Zhong Z.F.1,5; Sang W.1; Xiong W.1; Tao H.X.1; Zhao G.D.1; Li Z.X.1; Ma Q.S.1; Tse A.K.W.5; Hu Y.J.1; Yu H.1,2,3; Wang Y.T.1
2019-01-10
Source PublicationJournal of Ethnopharmacology
ISSN0378-8741
Volume228Pages:200-209
Abstract

Ethnopharmacological relevance: Siegesbeckiae Herba (SH) is a traditional anti-rheumatic herbal medicine in China. The SH-derived product is the first licensed traditional herbal medicinal product for the management of rheumatism-induced joint and muscle pain in United Kingdom. The authenticated plant origins listed in the official Chinese Pharmacopeia for SH include Siegesbeckia orientalis L. (SO), S. pubescens Markino (SP) and S. glabrescens Markino (SG). Although the therapeutic effects of these SH species in treating rheumatoid arthritis (RA) are similar, their difference in chemical profiles suggested their anti-rheumatisms mechanisms and effects may be different. Aim of the study: This study was designed to comparatively comprehend the chemical and biological similarity and difference of SO, SP and SG for treating rheumatoid arthritis based on the combination of computational predictions and biological experiment investigations. Materials and methods: The reported compounds for SO, SP and SG were obtained from four chemical databases (SciFinder, Combined Chemical Dictionary v2009, Dictionary of Natural Products and Chinese academy of sciences Chemistry Database). The RA-relevant proteins involved in nuclear factor-kappa B (NF-κB), oxidative stress and autophagy signaling pathways were collected from the databases of Kyoto Encyclopedia of Genes and Genomes and Biocarta. The comparative comprehension of SH plants was performed using similarity analysis, molecular docking and compounds-protein network analysis. The chemical characterization of different SH extracts were qualitatively and quantitatively analyzed, and their effects on specific RA-relevant protein expressions were investigated using Western blotting analysis. Results: Chemical analysis revealed that SO contains mainly sequiterpenes and pimarenoids; SP contains mainly pimarenoids, sequiterpenes, and kaurenoids; and SG contains mainly pimarenoids, flavonoids and alkaloids. Moreover, coincided with the predicted results from computational analysis, different SH species were observed to present different chemical constituents, and diverse effects on RA-relevant proteins at the biological level. Conclusions: The chemical and biological properties of SO, SP and SG were different and distinctive. The systematic comparison between these three confusing Chinese herbs provides reliable characterization profiles to clarify the pharmacological substances in SH for the precise management of rheumatism/-related diseases in clinics.

KeywordComputational Prediction Difference Rheumatoid Arthritis Siegesbeckiae Herba Similarity
DOI10.1016/j.jep.2018.09.023
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000452344800021
PublisherELSEVIER IRELAND LTD
Scopus ID2-s2.0-85055282036
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionTHE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Institute of Chinese Medical Sciences
Corresponding AuthorHu Y.J.; Yu H.
Affiliation1.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao SAR, China
2.HKBU Shenzhen Research Center, Shenzhen, Guangdong, China
3.School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China
4.School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, China
5.Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, Guangdong, China
6.Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhang Q.R.,Zhong Z.F.,Sang W.,et al. Comparative comprehension on the anti-rheumatic Chinese herbal medicine Siegesbeckiae Herba: Combined computational predictions and experimental investigations[J]. Journal of Ethnopharmacology, 2019, 228, 200-209.
APA Zhang Q.R.., Zhong Z.F.., Sang W.., Xiong W.., Tao H.X.., Zhao G.D.., Li Z.X.., Ma Q.S.., Tse A.K.W.., Hu Y.J.., Yu H.., & Wang Y.T. (2019). Comparative comprehension on the anti-rheumatic Chinese herbal medicine Siegesbeckiae Herba: Combined computational predictions and experimental investigations. Journal of Ethnopharmacology, 228, 200-209.
MLA Zhang Q.R.,et al."Comparative comprehension on the anti-rheumatic Chinese herbal medicine Siegesbeckiae Herba: Combined computational predictions and experimental investigations".Journal of Ethnopharmacology 228(2019):200-209.
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