Synthesis and Evaluation of O 2-Derived Diazeniumdiolates Activatable via Bioorthogonal Chemistry Reactions in Living Cells

doi:10.1021/acs.orglett.8b00423

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	Synthesis and Evaluation of O 2-Derived Diazeniumdiolates Activatable via Bioorthogonal Chemistry Reactions in Living Cells
	Tian Lv 2; Jianbing Wu 2; Fenghua Kang 2; Tingting Wang 2; Boheng Wan 2; Jin-Jian Lu1 ; Yihua Zhang 2; Zhangjian Huang 2
	2018-04-20
Source Publication	Organic Letters
ISSN	15237052 15237060
Volume	20 Issue:8 Pages:2164-2167
Abstract	A class of O-alkyl derived diazeniumdiolates 3a-f and 4a-c were designed and synthesized as new bioorthogonal NO precursors, which can be effectively uncaged in the presence of a palladium catalyst via bioorthogonal bond cleavage reactions to generate NO in living cancer cells, eliciting potent antiproliferative activity.
DOI	10.1021/acs.orglett.8b00423
URL	View the original
Indexed By	SCIE
WOS Research Area	Chemistry
WOS Subject	Chemistry, Organic
WOS ID	WOS:000430898200009
Scopus ID	2-s2.0-85045957749
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	DEPARTMENT OF PHARMACEUTICAL SCIENCES Institute of Chinese Medical Sciences THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding Author	Zhangjian Huang
Affiliation	1.Universidade de Macau 2.China Pharmaceutical University
Recommended Citation GB/T 7714	Tian Lv,Jianbing Wu,Fenghua Kang,et al. Synthesis and Evaluation of O 2-Derived Diazeniumdiolates Activatable via Bioorthogonal Chemistry Reactions in Living Cells[J]. Organic Letters, 2018, 20(8), 2164-2167.
APA	Tian Lv., Jianbing Wu., Fenghua Kang., Tingting Wang., Boheng Wan., Jin-Jian Lu., Yihua Zhang., & Zhangjian Huang (2018). Synthesis and Evaluation of O 2-Derived Diazeniumdiolates Activatable via Bioorthogonal Chemistry Reactions in Living Cells. Organic Letters, 20(8), 2164-2167.
MLA	Tian Lv,et al."Synthesis and Evaluation of O 2-Derived Diazeniumdiolates Activatable via Bioorthogonal Chemistry Reactions in Living Cells".Organic Letters 20.8(2018):2164-2167.

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