Patent valuation has long been a serious concern in the research-oriented pharmaceutical industry. Although there exists both technological valuation models for specific drug patents and the general (non-drug-specific) patent valuation models based on econometrics, direct application of these models to patent valuation in the pharmaceutical industry encounters tremendous challenges. This article proposes an integrative and systematic framework for analyzing pharmaceutical patent value, which integrates technological, commercial and legal indicators. This work is of great significance to pharmaceutical researchers, managers and investors in their decision-making in relation to patents and patent value.