Preparation and anti-tumor activity study of long-circulating, self-assembled gambogic acid nanoparticles 藤黄酸长循环纳米粒的制备及其抗肿瘤作用研究

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	Preparation and anti-tumor activity study of long-circulating, self-assembled gambogic acid nanoparticles 藤黄酸长循环纳米粒的制备及其抗肿瘤作用研究
	Guo M.-R.1; Wang F.1; Chen L.-J.1; Ouyang D.-F.3 ; Liu Y.1; Liang X.1; Zhang G.-L.1; Zhang J.-F.1; Liu H.-S.2
	2018-07-30
Source Publication	Chinese Journal of New Drugs
ISSN	10033734
Volume	27 Issue:14 Pages:1639-1644
Abstract	Objective:To synthesize amphiphilic triblock polymer polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) as carriers of gambogic acid (GA) and study its preparation process, antitumor activity and pharmacokinetics. Methods:The PCL-PEG-PCL was synthesized by polymerization reaction and was used as nanoparticle materials to obtain GA-loaded nanoparticles. The encapsulation efficiency,particle size,release rate and anti-tumor activities in vitro were investigated. Results:The particle size of nanoparticles with optimal formulation and process was around 226.5 nm and the PDI was 0.208. The encapsulation efficiency was above 92%. The release of GA-loaded nanoparticles was less than 40% in 0.5 h and showed no obvious burst release. The cell inhibition rate of GA-loaded micelles was lower than that of GA after 24 h but higher than it after 36 h. Conclusion:The GA-loaded nanoparticles demonstrated good long-circulating activities and slow-release characteristic in vitro and the GA-loaded nanoparticles showed good anti-tumor activities.
Keyword	Anti-tumor Gambogic acid Nanoparticles PCL-PEG-PCL
URL	View the original
Language	中文Chinese
Fulltext Access	View Full-Text via Scopus
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Affiliation	1.Liaoning University 2.Research Center for Computer Simulating and Information Processing of Bio-macromolecules of Liaoning Province 3.Universidade de Macau
Recommended Citation GB/T 7714	Guo M.-R.,Wang F.,Chen L.-J.,等. Preparation and anti-tumor activity study of long-circulating, self-assembled gambogic acid nanoparticles 藤黄酸长循环纳米粒的制备及其抗肿瘤作用研究[J]. Chinese Journal of New Drugs, 2018, 27(14), 1639-1644.
APA	Guo M.-R.., Wang F.., Chen L.-J.., Ouyang D.-F.., Liu Y.., Liang X.., Zhang G.-L.., Zhang J.-F.., & Liu H.-S. (2018). Preparation and anti-tumor activity study of long-circulating, self-assembled gambogic acid nanoparticles 藤黄酸长循环纳米粒的制备及其抗肿瘤作用研究. Chinese Journal of New Drugs, 27(14), 1639-1644.
MLA	Guo M.-R.,et al."Preparation and anti-tumor activity study of long-circulating, self-assembled gambogic acid nanoparticles 藤黄酸长循环纳米粒的制备及其抗肿瘤作用研究".Chinese Journal of New Drugs 27.14(2018):1639-1644.

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