The coordinated implementation of demand response technology and dynamic energy prices facilitates the interaction among multiple stakeholders in the smart integrated energy system. To achieve the optimal operation between different entities in the system, this paper proposes a multi-objective optimization model for smart integrated energy system considering demand responses and dynamic prices that reflects the preferences of multiple stakeholders. Based on the tightly coupled characteristics of a multi-energy system, a flexible two-dimensional demand response model with spatio-temporal coupling characteristics is established. By analyzing the characteristics of multi-entities joint pricing, the dynamic energy price formulated with the participation of both supplier and demander is optimized, and the dynamic price control strategy of different stakeholders under different benefit weights is obtained. A case study verifies the effectiveness of the proposed method. According to the interest preferences of different entities, different strategies and operating mechanisms can be derived, which is conducive to improving the economy and reliability of the operation of the smart integrated energy system and promoting the interaction between multiple entities.