Transplacental transfer and metabolism of 17-α-hydroxyprogesterone caproate

doi:10.1016/j.ajog.2007.11.065

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	Transplacental transfer and metabolism of 17-α-hydroxyprogesterone caproate
	Sarah J. Hemauer 1; Ru Yan 1; Svetlana L. Patrikeeva 1; Donald R. Mattison 2; Gary D. V. Hankins 1; Mahmoud S. Ahmed 1; Tatiana N. Nanovskaya 1
	2008-08
Source Publication	American Journal of Obstetrics and Gynecology
ISSN	0002-9378
Volume	199 Issue:2 Pages:169.e1-169.e5
Abstract
Other Abstract	Objective Determine transplacental transfer and metabolism of 17-α-hydroxyprogesterone caproate and its distribution between the tissue and the maternal and fetal circuits of the dually perfused placental lobule. Study Design 17-α-Hydroxyprogesterone caproate (21 ng/mL) and its dual-labeled isotope, 17-α-hydroxy-[³H] progesterone [¹⁴C] caproate were added to the maternal circuit. The concentrations of the drug and its metabolite in trophoblast tissue and both circuits were determined by high performance liquid chromatography and liquid scintillation spectrometry. Results 17-α-Hydroxyprogesterone caproate was transferred from the maternal to fetal circuit. After a 4-hour perfusion period, a metabolite of 17-α-hydroxyprogesterone caproate that retained both progesterone and caproate moieties was identified in the tissue and the maternal and fetal circuits. Neither 17-α-hydroxyprogesterone caproate nor its metabolite, at the concentrations tested, had adverse effect on determined viability and functional parameters of placental tissue. Conclusion 17-α-Hydroxyprogesterone caproate was metabolized by term placental lobule during its perfusion and both parent compound and its metabolite(s) transferred to the fetal circuit.
Keyword	Dual Perfusion Metabolism Preterm Delivery 17-α-hydroxyprogesterone Caproate
DOI	10.1016/j.ajog.2007.11.065
Indexed By	SCIE
Language	英語English
WOS Research Area	Obstetrics & Gynecology
WOS Subject	Obstetrics & Gynecology
WOS ID	WOS:000258031500031
Publisher	MOSBY-ELSEVIER, 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
Scopus ID	2-s2.0-47949096412
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science
Citation statistics
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Affiliation	1.Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 2.Obstetric-Fetal Pharmacology Research Unit (OPRU) Network, Center for Research for Mothers & Children, National Institute of Child Health and Human Development, Bethesda, MD.
Recommended Citation GB/T 7714	Sarah J. Hemauer,Ru Yan,Svetlana L. Patrikeeva,et al. Transplacental transfer and metabolism of 17-α-hydroxyprogesterone caproate[J]. American Journal of Obstetrics and Gynecology, 2008, 199(2), 169.e1-169.e5.
APA	Sarah J. Hemauer., Ru Yan., Svetlana L. Patrikeeva., Donald R. Mattison., Gary D. V. Hankins., Mahmoud S. Ahmed., & Tatiana N. Nanovskaya (2008). Transplacental transfer and metabolism of 17-α-hydroxyprogesterone caproate. American Journal of Obstetrics and Gynecology, 199(2), 169.e1-169.e5.
MLA	Sarah J. Hemauer,et al."Transplacental transfer and metabolism of 17-α-hydroxyprogesterone caproate".American Journal of Obstetrics and Gynecology 199.2(2008):169.e1-169.e5.

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Objective

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