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A real-time correlational combination algorithm to improve SNR for multi-channel neural recordings
Wang, Liyang1,5; Pun, Sio Hang1,5; Mak, Peng Un2,5; Klug, Achim3,5; Zhang, Bai Jun4,5; Vai, Mang I.1,5; Lei, Tim C.3,5
2021-11
Conference Name2021 IEEE Asia Pacific Conference on Circuits and Systems, APCCAS 2021 and 2021 IEEE Conference on Postgraduate Research in Microelectronics and Electronics, PRIMEASIA 2021
Source Publication2021 IEEE Asia Pacific Conference on Circuits and Systems, APCCAS 2021 and 2021 IEEE Conference on Postgraduate Research in Microelectronics and Electronics, PRIMEASIA 2021
Pages213-216
Conference Date2021-11
Conference PlacePenang
CountryMalaysia
Publication PlaceIEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA
PublisherIEEE
Abstract

This paper presents a Correlational Combination (CC) algorithm and its hardware implementation to be used in future multi-channel real-time spike sorting systems. Preprocessing of neural spikes are required to eliminate duplication for neural spikes recorded from a neural probe with densely spaced recording channels. In this work, we proposed using Pearson's correlation to identify duplicated neural spikes and to combine them selectively to improve SNR for a representative spike prior to performing spike sorting. Other approaches (Single Selection and Average All) were also compared with simulated multi-channel neural spikes and CC has the highest SNR for both software and hardware implementations. A hardware implementation of the CC algorithm was realized with a Xilinx Zynq-UltraScale+ field programmable gate array (FPGA). A SNR improvement of 93% was achieved when compared to the other approaches. A processing latency of 1.58μmu s for the CC hardware module was achieved when a 250MHz system clock was used to drive the FPGA.

DOI10.1109/APCCAS51387.2021.9687737
URLView the original
Indexed ByCPCI-S
Language英語English
WOS Research AreaComputer Science ; Telecommunications
WOS SubjectComputer Science, Information Systems ; Computer Science, Theory & Methods ; Telecommunications
WOS IDWOS:000791022500053
Scopus ID2-s2.0-85126701013
Fulltext Access
Citation statistics
Document TypeConference paper
CollectionTHE STATE KEY LABORATORY OF ANALOG AND MIXED-SIGNAL VLSI (UNIVERSITY OF MACAU)
INSTITUTE OF MICROELECTRONICS
DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
Affiliation1.Institute of Microelectronics, University of Macau, State Key Laboratory of Analog and Mixed-Signal VLSI, Macao
2.Department of Electrical and Computer Engineering, University of Macau, Macao
3.Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, United States
4.School of Electronics and Information Technology, State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-sen University, Guangzhou, China
5.Department of Electrical Engineering, University of Colorado, Denver, United States
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Wang, Liyang,Pun, Sio Hang,Mak, Peng Un,et al. A real-time correlational combination algorithm to improve SNR for multi-channel neural recordings[C], IEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA:IEEE, 2021, 213-216.
APA Wang, Liyang., Pun, Sio Hang., Mak, Peng Un., Klug, Achim., Zhang, Bai Jun., Vai, Mang I.., & Lei, Tim C. (2021). A real-time correlational combination algorithm to improve SNR for multi-channel neural recordings. 2021 IEEE Asia Pacific Conference on Circuits and Systems, APCCAS 2021 and 2021 IEEE Conference on Postgraduate Research in Microelectronics and Electronics, PRIMEASIA 2021, 213-216.
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