With the increasing integration of distributed PV generation, the distribution network requires more and more flexibility to achieve the security-constrained optimal power dispatch. However, the conventional flexibility sources usually require additional investment cost for equipment. Moreover, involving the security constraints is very challenging due to the requirements of accurate network model that may be unavailable in practice. This paper addresses the aforementioned challenge by proposing a topology-free optimal power dispatch framework for distribution networks. It utilizes building thermal inertia to provide flexibility to avoid additional investment. To guarantee the operation safety, a multi-layer perception (MLP) is trained based on historical operational data and then reformulated as mixed-integer constraints to replace the inexplicit original security constraints. Numerical results confirm that the proposed framework can derive a feasible and optimal strategy without any topology information.