T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis

doi:10.1074/jbc.M112.378398

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	T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis
	Rogers H.1; Wang L.1 ; Yu X.1; Alnaeeli M.1; Cui K.7; Zhao K.7; Bieker J.J.5; Prchal J.6; Huang S.4; Weksler B.2; Noguchi C.T.1
	2012-10-26
Source Publication	Journal of Biological Chemistry
ISSN	00219258 1083351X
Volume	287 Issue:44 Pages:36720-36731
Abstract	Background: Erythropoietin is required for erythrocyte production and stimulates erythroid gene expression including EPO-R. Results: TAL1 induction promotes accessibility of EPO-R promoter to the GATA-1-TAL1-LMO2-LDB1 transcription activation complex to increase EPO-R expression. Conclusion: Forced TAL1 expression increases EPO-R and erythropoietin hypersensitivity in erythroid progenitors. Significance: Providing insight into the molecular link between TAL1 and erythropoietin activity.
DOI	10.1074/jbc.M112.378398
URL	View the original
Indexed By	SCIE
WOS Research Area	Biochemistry & Molecular Biology
WOS Subject	Biochemistry & Molecular Biology
WOS ID	WOS:000310588500010
Scopus ID	2-s2.0-84868228743
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Faculty of Health Sciences
Affiliation	1.NIDDK 2.Weill Cornell Medical College 3.University of California, San Francisco 4.University of Florida College of Medicine 5.Icahn School of Medicine at Mount Sinai 6.University of Utah 7.National Heart, Lung, and Blood Institute
Recommended Citation GB/T 7714	Rogers H.,Wang L.,Yu X.,et al. T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis[J]. Journal of Biological Chemistry, 2012, 287(44), 36720-36731.
APA	Rogers H.., Wang L.., Yu X.., Alnaeeli M.., Cui K.., Zhao K.., Bieker J.J.., Prchal J.., Huang S.., Weksler B.., & Noguchi C.T. (2012). T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. Journal of Biological Chemistry, 287(44), 36720-36731.
MLA	Rogers H.,et al."T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis".Journal of Biological Chemistry 287.44(2012):36720-36731.

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