| Residential College | false |
| Status | 已發表Published |
| Could ginseng-based medicines be better than nitrates in treating ischemic heart disease? A systematic review and meta-analysis of randomized controlled trials | |
Yongliang Jia1,2 ; Shikai Zhang1,2; Fangyi Huang3; Siu-wai Leung1,2,4
| |
| 2012 | |
| Source Publication | Complementary Therapies in Medicine
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| ISSN | 0965-2299 |
| Volume | 20Issue:3Pages:155-166 |
| Other Abstract | BackgroundGinseng-based medicines and nitrates are commonly used in treating ischemic heart disease (IHD) angina pectoris in China. Hundreds of randomized controlled trials (RCTs) reported in Chinese language claimed that ginseng-based medicines can relieve the symptoms of IHD. This study provides the first PRISMA-compliant systematic review with sensitivity and subgroup analyses to evaluate the RCTs comparing the efficacies of ginseng-based medicines and nitrates in treating ischemic heart disease, particularly angina pectoris. MethodsPast RCTs published up to 2010 on ginseng versus nitrates in treating IHD for 14 or more days were retrieved from major English and Chinese databases, including PubMed, Science Direct, Cochrane Library, WangFang Data, and Chinese National Knowledge Infrastructure. The qualities of included RCTs were assessed with Jadad scale, a refined Jadad scale called M scale, CONSORT 2010 checklist, and Cochrane risk of bias tool. Meta-analysis was performed on the primary outcomes including the improvement of symptoms and electrocardiography (ECG). Subgroup analysis, sensitivity analysis, and meta-regression were performed to evaluate the effects of study characteristics of RCTs, including quality, follow-up periods, and efficacy definitions on the overall effect size of ginseng. ResultsEighteen RCTs with 1549 participants were included. Overall odds ratios for comparing ginseng-based medicines with nitrates were 3.00 (95% CI: 2.27–3.96) in symptom improvement (n = 18) and 1.61 (95% CI: 1.20–2.15) in ECG improvement (n = 10). Subgroup analysis, sensitivity analysis, and meta-regression found no significant difference in overall effects among all study characteristics, indicating that the overall effects were stable. ConclusionThe meta-analysis of 18 eligible RCTs demonstrates moderate evidence that ginseng is more effective than nitrates for treating angina pectoris. However, further RCTs for higher quality, longer follow-up periods, lager sample size, multi-center/country, and are still required to verify the efficacy. |
| Keyword | Ginseng Nitrates Ischemic Heart Disease Angina Pectoris Randomized Controlled Trials Meta-analysis Systematic Review |
| DOI | 10.1016/j.ctim.2011.12.002 |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Integrative & Complementary Medicine |
| WOS Subject | Integrative & Complementary Medicine |
| WOS ID | WOS:000303635400007 |
| Scopus ID | 2-s2.0-84859702971 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine (University of Macau), Taipa, Macao SAR, China 2.School of Informatics, University of Edinburgh, Edinburgh EH8 9AB, United Kingdom 3.Institute of Chinese Medical Sciences, The University of Macau, Taipa, Macao SAR, China 4.Faculty of Social Sciences and Humanities, The University of Macau, Taipa, Macao SAR, China |
| First Author Affilication | University of Macau |
| Recommended Citation GB/T 7714 | Yongliang Jia,Shikai Zhang,Fangyi Huang,et al. Could ginseng-based medicines be better than nitrates in treating ischemic heart disease? A systematic review and meta-analysis of randomized controlled trials[J]. Complementary Therapies in Medicine, 2012, 20(3), 155-166. |
| APA | Yongliang Jia., Shikai Zhang., Fangyi Huang., & Siu-wai Leung (2012). Could ginseng-based medicines be better than nitrates in treating ischemic heart disease? A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine, 20(3), 155-166. |
| MLA | Yongliang Jia,et al."Could ginseng-based medicines be better than nitrates in treating ischemic heart disease? A systematic review and meta-analysis of randomized controlled trials".Complementary Therapies in Medicine 20.3(2012):155-166. |
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