Residential College | false |
Status | 已發表Published |
Chemical Stability of a Chinese Herbal Spirit Using LC-MS-Based Metabolomics and Accelerated Tests | |
Hu, Yan1,2![]() ![]() ![]() ![]() ![]() | |
2022-03-07 | |
Source Publication | Frontiers in Pharmacology
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Volume | 13 |
Other Abstract | As a prevalent medicinal liquor among Chinese people, a type of Chinese herbal spirit from Jing Brand Co., Ltd (CHS-J) is a newly developed health beverage with the health functions of anti-fatigue and immune enhancement. The researchers from the enterprise found that the contents of several components in CHS-J samples have been significantly decreasing during the stated storage period, as detected by the HPLC-UV method, which would make a great challenge for quality control of CHS-J. Furthermore, the chemical stability of CHS-J during the storage period is greatly challenged affected, especially in the environment of high temperature and light exposure. To systematically reveal the unstable components and promote the quality control of CHS-J, the chemical stability of CHS-J during the shelving storage period was characterized by the UPLC/Q-TOFMS-based metabolomics approach. First, the targeted and untargeted metabolomics approaches discovered the significantly changed components in CHS-J samples produced in different years. Furthermore, the accelerated tests of newly produced CHS samples and several authorized standards were conducted to validate the above results and elucidate the possible mechanisms underlying these chemical changes. Moreover, these chemical changes during the storage period had little influence on the anti-fatigue effect of CHS-J samples. These findings will offer new insight into the understanding of the chemical stability of CHS-J and will facilitate the quality control of CHS-J. |
Keyword | Accelerated Test Anti-fatigue Chinese Herbal Spirit Metabolomics Quality Control |
DOI | 10.3389/fphar.2022.857706 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Pharmacology & Pharmacy |
WOS Subject | Pharmacology & Pharmacy |
WOS ID | WOS:000777736400001 |
Scopus ID | 2-s2.0-85127256598 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Institute of Chinese Medical Sciences THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU) |
Corresponding Author | Chen, Xiao-Jia; Wan, Jian-Bo |
Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 2.State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China 3.Hubei Provincial Key Laboratory for Quality and Safety of Traditional, Chinese Medicine Health Food, Jing Brand Co., Ltd, Wuhan, China 4.Pharmacy School, Hubei University of Chinese Medicine, Wuhan, China |
First Author Affilication | Institute of Chinese Medical Sciences |
Corresponding Author Affilication | Institute of Chinese Medical Sciences |
Recommended Citation GB/T 7714 | Hu, Yan,Wang, Zhe,Liu, Jiayue,et al. Chemical Stability of a Chinese Herbal Spirit Using LC-MS-Based Metabolomics and Accelerated Tests[J]. Frontiers in Pharmacology, 2022, 13. |
APA | Hu, Yan., Wang, Zhe., Liu, Jiayue., Yang, Wen., Yang, Qiang., Liu, Yuan-Cai., You, Qiu-Yun., Chen, Xiao-Jia., & Wan, Jian-Bo (2022). Chemical Stability of a Chinese Herbal Spirit Using LC-MS-Based Metabolomics and Accelerated Tests. Frontiers in Pharmacology, 13. |
MLA | Hu, Yan,et al."Chemical Stability of a Chinese Herbal Spirit Using LC-MS-Based Metabolomics and Accelerated Tests".Frontiers in Pharmacology 13(2022). |
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