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Chemical Stability of a Chinese Herbal Spirit Using LC-MS-Based Metabolomics and Accelerated Tests
Hu, Yan1,2; Wang, Zhe3; Liu, Jiayue3; Yang, Wen3; Yang, Qiang3; Liu, Yuan-Cai3; You, Qiu-Yun4; Chen, Xiao-Jia1; Wan, Jian-Bo1
2022-03-07
Source PublicationFrontiers in Pharmacology
Volume13
Other Abstract

As a prevalent medicinal liquor among Chinese people, a type of Chinese herbal spirit from Jing Brand Co., Ltd (CHS-J) is a newly developed health beverage with the health functions of anti-fatigue and immune enhancement. The researchers from the enterprise found that the contents of several components in CHS-J samples have been significantly decreasing during the stated storage period, as detected by the HPLC-UV method, which would make a great challenge for quality control of CHS-J. Furthermore, the chemical stability of CHS-J during the storage period is greatly challenged affected, especially in the environment of high temperature and light exposure. To systematically reveal the unstable components and promote the quality control of CHS-J, the chemical stability of CHS-J during the shelving storage period was characterized by the UPLC/Q-TOFMS-based metabolomics approach. First, the targeted and untargeted metabolomics approaches discovered the significantly changed components in CHS-J samples produced in different years. Furthermore, the accelerated tests of newly produced CHS samples and several authorized standards were conducted to validate the above results and elucidate the possible mechanisms underlying these chemical changes. Moreover, these chemical changes during the storage period had little influence on the anti-fatigue effect of CHS-J samples. These findings will offer new insight into the understanding of the chemical stability of CHS-J and will facilitate the quality control of CHS-J.

KeywordAccelerated Test Anti-fatigue Chinese Herbal Spirit Metabolomics Quality Control
DOI10.3389/fphar.2022.857706
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000777736400001
Scopus ID2-s2.0-85127256598
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding AuthorChen, Xiao-Jia; Wan, Jian-Bo
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
2.State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
3.Hubei Provincial Key Laboratory for Quality and Safety of Traditional, Chinese Medicine Health Food, Jing Brand Co., Ltd, Wuhan, China
4.Pharmacy School, Hubei University of Chinese Medicine, Wuhan, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Hu, Yan,Wang, Zhe,Liu, Jiayue,et al. Chemical Stability of a Chinese Herbal Spirit Using LC-MS-Based Metabolomics and Accelerated Tests[J]. Frontiers in Pharmacology, 2022, 13.
APA Hu, Yan., Wang, Zhe., Liu, Jiayue., Yang, Wen., Yang, Qiang., Liu, Yuan-Cai., You, Qiu-Yun., Chen, Xiao-Jia., & Wan, Jian-Bo (2022). Chemical Stability of a Chinese Herbal Spirit Using LC-MS-Based Metabolomics and Accelerated Tests. Frontiers in Pharmacology, 13.
MLA Hu, Yan,et al."Chemical Stability of a Chinese Herbal Spirit Using LC-MS-Based Metabolomics and Accelerated Tests".Frontiers in Pharmacology 13(2022).
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