The COVID-19 pandemic shows growing demand of robots to replace humans for conducting multiple tasks including logistics, patient care, and disinfection in contaminated areas. In this paper, a new autonomous disinfection robot is proposed based on aerosolized hydrogen peroxide disinfection method. Its unique feature lies in that the autonomous navigation is planned by developing an atomization disinfection model and a target detection algorithm, which enables cost-effective, point-of-care, and full-coverage disinfection of the air and surface in indoor environment. A prototype robot has been fabricated for experimental study. The effectiveness of the proposed concept design for automated indoor environmental disinfection has been verified with air and surface quality monitoring provided by a qualified third-party testing agency. Note to Practitioners - Robots are desirable to reduce the risk of human infection of highly contagious virus. For such purpose, a novel autonomous disinfection robot is designed herein for automated disinfection of air and surface in indoor environment. The robot structure consists of a mobile carrier platform and an atomizer disinfection module. The disinfection modeling is conducted by using the measurement data provided by a custom-built PM sensor array. To achieve cost-effective and qualified disinfection, a full-coverage path planning scheme is proposed based on the established disinfection model. Moreover, for specifically disinfecting the frequently contacted objects (e.g., tables and chairs in offices and hospitals), a target perception algorithm is proposed to mark the localization of these objects in the map, which are disinfected by the robot more carefully in these marked areas. Experimental results indicate that the developed disinfection robot offers great effectiveness to fight against the COVID-19 pandemic.