| Residential College | false |
| Status | 即將出版Forthcoming |
| Anti-lipopolysaccharide effect of ultrafine granular powder of Houttuynia cordata 鱼腥草破壁饮片抗细菌内毒素作用研究 | |
| Dai, Yao Lan1,2; Li, Shao Jing2; Yang, Ruo Cong3; Wu, Chuan Hong4; Duan, Fei Peng3; Chen, Wei Xuan5,6; Gong, Ming3; Wang, Pei Pei3; Li, Xue Li3; Sun, Yan2; Cheng, Jin Le5,6; Yan, Zhi Yong1 | |
| 2019-09-12 | |
| Source Publication | Chinese Traditional and Herbal Drugs
 |
| ISSN | 0253-2670 |
| Volume | 50Issue:17Pages:4225-4231 |
| Abstract | Objective: To study the anti-lipopolysaccharide (LPS) effect of the ultrafine granular powder of Houttuynia cordata and the effects in comparison with traditional decoction pieces. Methods: BALB/c mice were injected with LPS through nose to establish lung inflammation model. The number of leukocytes in mice whole blood was examined, and the degree of the inflammation of lung tissue by pathology was observed. Rat inflammatory model was induced by injection of LPS into tail vein. The number of leukocytes in mice whole blood, content of LPS in plasma were examined, the content of IL-1β, IL-6, and TNF-α in serum were detected by enzyme-linked immunoadsordent assay (ELISA). The limulus test method was used to detect the anti- lipopolysaccharide effect of the ultrafine granular powder of H. cordata in vitro. Results: The ultrafine granular powder of H. cordata and traditional decoction pieces can reduce the level of leukocytes in mice whole blood in various degrees, and alleviated the infiltration of inflammatory cells in pathological lung tissue, and there was a positive dosage dependent relation. For the two decoction pieces, the number of leukocytes in rat whole blood, the content of LPS in plasma, the levels of IL-1β, IL-6, and TNF-α in serum decreased in different degrees were found. Compared with traditional decoction pieces group, the content of IL-1β and TNF-α of serum in ultrafine granular powder group were significant decreased. The ultrafine granular powder of H. cordata showed better anti-inflammatory activity than traditional decoction pieces in vitro at the same concentration and same dilution ratio. Conclusion: The ultrafine granular powder of H. cordata has satisfactory anti-lipopolysaccharide effect, and the effect is better than traditional decoction pieces in some extent. |
| Keyword | IL-1β IL-6 Inflammation Lipopolysaccharide TNF-α Ultrafine granular powder of Houttuynia cordata Thunb |
| URL | View the original |
| Language | 中文Chinese |
| Scopus ID | 2-s2.0-85074647030 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.College of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China 2.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China 3.Beijing University of Chinese Medicine, Beijing, 100029, China 4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macao 5.Key Laboratory of Technologies and Applications of Ultrafine Granular Powder of Herbal Medicine, State Administration of Traditional Chinese Medicine, Zhongshan, 528437, China 6.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., Zhongshan, 528437, China |
| Recommended Citation GB/T 7714 | Dai, Yao Lan,Li, Shao Jing,Yang, Ruo Cong,等. Anti-lipopolysaccharide effect of ultrafine granular powder of Houttuynia cordata 鱼腥草破壁饮片抗细菌内毒素作用研究[J]. Chinese Traditional and Herbal Drugs, 2019, 50(17), 4225-4231. |
| APA | Dai, Yao Lan., Li, Shao Jing., Yang, Ruo Cong., Wu, Chuan Hong., Duan, Fei Peng., Chen, Wei Xuan., Gong, Ming., Wang, Pei Pei., Li, Xue Li., Sun, Yan., Cheng, Jin Le., & Yan, Zhi Yong (2019). Anti-lipopolysaccharide effect of ultrafine granular powder of Houttuynia cordata 鱼腥草破壁饮片抗细菌内毒素作用研究. Chinese Traditional and Herbal Drugs, 50(17), 4225-4231. |
| MLA | Dai, Yao Lan,et al."Anti-lipopolysaccharide effect of ultrafine granular powder of Houttuynia cordata 鱼腥草破壁饮片抗细菌内毒素作用研究".Chinese Traditional and Herbal Drugs 50.17(2019):4225-4231. |
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