Protective effect of recombinant hepatical stimulator analogue on concanavalina A-induced acute liver injury in mice

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	Protective effect of recombinant hepatical stimulator analogue on concanavalina A-induced acute liver injury in mice
	Zhang X.-Y.; Hang Y.-F.; Wang J.; Ding X.-S.; Wang Y.; Ye B.-P.
	2011-08-01
Source Publication	Journal of China Pharmaceutical University
ISSN	10005048
Volume	42 Issue:4 Pages:375-379
Abstract	To study the effect of recombinant shark hepatical stimulator analogue (r-sHSA) on Con A-induced acute liver injury in mice, serum aminotransferase activities and histological changes of hepatocytes were measured to assess the protective effect of r-sHSA (30, 60, 120 μg/kg). Hepatic malondialdehyde (MDA), glutathione (GSH) and total antioxidative capacity (T-AOC) levels, serum TNF-α and IFN-γ levels, and the activity of iNOS in hepatic homogenates were measured, respectively. Within all the three treated dosages, r-sHSA exhibited significant hepatoprotective effect by decreasing mouse serum aminotransferase activities, ameliorating hepatocyte necrosis and reducing inflammatory cell infiltration. The protection mechanism might be related with the reduced hepatic oxidative stress and proinflammatory cytokine production by r-sHSA pretreatment. These results indicated that r-sHSA could protect mice from Con A-induced acute liver injury through its antioxidant and anti-inflammatory activities.
Keyword	Acute liver injury Anti-inflammation Concanavalina A Protection Recombinant shark hepatical stimulator analogue (r-sHSA)
URL	View the original
Language	英語English
Fulltext Access	View Full-Text via Scopus
Document Type	Journal article
Collection	University of Macau
Affiliation	China Pharmaceutical University
Recommended Citation GB/T 7714	Zhang X.-Y.,Hang Y.-F.,Wang J.,et al. Protective effect of recombinant hepatical stimulator analogue on concanavalina A-induced acute liver injury in mice[J]. Journal of China Pharmaceutical University, 2011, 42(4), 375-379.
APA	Zhang X.-Y.., Hang Y.-F.., Wang J.., Ding X.-S.., Wang Y.., & Ye B.-P. (2011). Protective effect of recombinant hepatical stimulator analogue on concanavalina A-induced acute liver injury in mice. Journal of China Pharmaceutical University, 42(4), 375-379.
MLA	Zhang X.-Y.,et al."Protective effect of recombinant hepatical stimulator analogue on concanavalina A-induced acute liver injury in mice".Journal of China Pharmaceutical University 42.4(2011):375-379.

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