UM
Patent NumberCN107617104A
Status申請中 Pending
LIGHT作为免疫佐剂制备重组病毒疫苗
Application NumberCN201610552226.1
Application Date2016-07-13
Rights Holder中国科学院深圳先进技术研究院
王蒲; 邹军辉; 卢晓华; 郑威; 赵琦
Date Available2018-01-23
Country中国 China
Abstract本发明提供了LIGHT作为免疫佐剂在制备EBV和HPV的重组病毒疫苗中的应用以及所制备的重组病毒疫苗。LIGHT作为免疫佐剂增强疫苗刺激机体产生抗体、诱发机体产生体液免疫应答、刺激淋巴细胞分泌IFN‑γ、刺激机体产生细胞免疫应答的能力。制备的重组病毒疫苗包括重组EBV疫苗或重组HPV疫苗。本发明提供的LIGHT免疫佐剂,在病毒疫苗诱导的机体免疫应答反应中,能够高效提高疫苗免疫效率,是一种良好的重组病毒疫苗免疫增强剂;其制备的重组病毒疫苗通过LIGHT介导的信号通路增强机体对疫苗的免疫应答反应、特异性抗体的产生和T淋巴细胞的活化和增殖,发挥高效抗病毒作用。
Language中文Chinese
Open (Notice) NumberCN107617104A
IPC Classification NumberA61K39/39 ; A61K39/245 ; A61K39/12 ; A61K48/00 ; A61P31/20 ; A61P31/22 ; A61P37/04
Patent Agent韩蕾 ; 姚亮
Agency北京三友知识产权代理有限公司 11127
Document TypePatent
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
王蒲,邹军辉,卢晓华,等. LIGHT作为免疫佐剂制备重组病毒疫苗. CN107617104A.
APA 王蒲., 邹军辉., 卢晓华., 郑威., & 赵琦 (2016-07-13). LIGHT作为免疫佐剂制备重组病毒疫苗.
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