Integrated circuit for simultaneous electrophysiology recording and optogenetic neural control

Patent Number	US11000225B2
Status	已授權 Granted
	Integrated circuit for simultaneous electrophysiology recording and optogenetic neural control
	2021-05-11
Application Number	US16024217
Application Date	2018-06-29
Rights Holder	University of Macau \| UNIVERSITY OF COLORADO ( THE REGENTS OF)
	Lei, Tim; Klug, Achim; Pun, Sio Hang; Chen, Changhao; Vai, Mang I.; Mak, Peng Un; McCullagh, Elizabeth
Date Available	2021-05-11
Country	United States
Abstract	Various embodiments of the present technology generally relate to a single monolithic IC to perform simultaneous optogenetic neural inhibition and extracellular electrophysiological recording in-vivo. Some embodiments include a low input capacitance (e.g., 9.7 pF) amplifier particularly tailored for the use of high-impedance electrodes to conduct single neuron extracellular recording integrated with programmable high current drivers for optogenetic stimulation or inhibition on the same IC chip. Some embodiments use a noise model to guide the IC design process to obtain parameters for optimal signal-to-noise ratio. The performance of the IC chip was demonstrated on an anesthetized gerbil expressed with inhibitory optogenetic protein (Halorhodopsin). Spontaneous action potentials from the fifth nerve of the brainstem were recorded by the amplifier and were subsequently inhibited by laser illumination. As a result, various embodiments of the IC allow neuroscience research and neural engineering applications to be conducted in an entirely new direction and can potentially be used in treatments for human mental diseases in the future.
Language	英語English
Open (Notice) Number	US11000225B2
IPC Classification Number	A61B5/00 ; A61N5/06
CPC Classification Number	A61B5/4836 ; A61B5/6868 ; A61B5/7246 ; A61N5/0622 ; A61N2005/0612 ; A61N2005/0626 ; A61B5/24 ; A61B5/04001
Agency	Ladas & Parry LLP
Document Type	Patent
Collection	University of Macau
Recommended Citation GB/T 7714	Lei, Tim,Klug, Achim,Pun, Sio Hang,et al. Integrated circuit for simultaneous electrophysiology recording and optogenetic neural control. US11000225B2[P]. 2021-05-11.
APA	Lei, Tim., Klug, Achim., Pun, Sio Hang., Chen, Changhao., Vai, Mang I.., Mak, Peng Un., & McCullagh, Elizabeth (2018-06-29). Integrated circuit for simultaneous electrophysiology recording and optogenetic neural control.

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