| Residential College | false |
| Status | 已發表Published |
| Effects of APRV-BIPAP ventilation on lung recruitment/open maneuvers in piglets with acute lung injury | |
| Yin N.; Song Z.-F.; Xie W.; Wu Z.-B.; Yang X.-L.; Ge X.-L.; Wang Y. | |
| 2008-11-10 | |
| Source Publication | Chinese Journal of Emergency Medicine
 |
| ISSN | 16710282 |
| Volume | 17Issue:11Pages:1147-1151 |
| Abstract | Objective: To study the effects of APRV (airway pressure release ventilation) / BIPAP(biphasic positive airway pressure) on lung recruitment/open maneuvers in piglets with acute lung injury. Method: The model of acute lung injury (ALI) was induced by E. coli. intraperitoneal injection in piglets. Based APRV/BIPAP model, the different pressure combinations (P/P) of RMs increased gradually, such as RM1(30/15), RM2(35/20), RM3(40/25), RM4(45/30), RM5(50/35), RM6(55/40), RM7(60/45) cmHO. The effects of stepwise RMs were studied by computed tomography (CT) at inspiratory phase. Meantime the oxygen index (PaO/FiO), hemodynamic parameter and mean pressure of airway (Pmean) were continuously observed. The piglets were killed when RMs finished and pulmonary pathological examination were done routinely by optical microscope. Data was analyzed by self-contrast method, using SPSS 11.5 software package. Results were expressed as mean ± standard deviation (x ± s). Multiple comparisons were made with One-way ANOVA. Pearson correlative analysis was used to describe the relativity of PaO/FiO and the collapsed alveolar area. Changes were considered as statistically significant if P value was less than 0.05. Results: Eight piglets with ALI model were successfully made and all of them showed different degree of alveolar collapse under chest CT scan. During RMs their PaO/FiO increased obviously (P < 0.05) were decreased obviously (P < 0.05) too, specially after RN12 finished (P < 0. 05). But the alveolar over-inflation could be found in some, non-diseased area. The heart rate (HR) increased and mean artery blood pressure (MAP) decreased significantly while the pressure combinations (P/P) of RMs were added gradually (P < 0.05). Meantime the P and P inspiratory pressure (PIP) of airway and central venous pressure (CVP) were increased significantly (P < 0.05). But when RMs were finished, all of these indexes were back to the levels of pre-RMs. Even there were no barotraumas happened, such as pneumothorax and pneumomediastinum, the alveolar overdistention and interruption of the alveolar separation still could be seen by pathologic examination. Conclusions: RMs could be done well by APRV/BIPAP. P/ P (35/20 cmHO) would be the best pressure combination with more efficacy of RMs and less influence on hemodynamics, airway pressure indexes and others. When the effect of RMs was satisfied enough, setting P/P to 30/15 cmHO for 20 min may maintain the good efficacy of RMs. |
| Keyword | Acute lung injury Airway pressure release ventilation/biphasic positive airway pressure Computed tomography Hemodynamics Lung recruitment/open maneuvers |
| URL | View the original |
| Language | 英語English |
| Fulltext Access | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | Shanghai Jiao Tong University |
| Recommended Citation GB/T 7714 | Yin N.,Song Z.-F.,Xie W.,et al. Effects of APRV-BIPAP ventilation on lung recruitment/open maneuvers in piglets with acute lung injury[J]. Chinese Journal of Emergency Medicine, 2008, 17(11), 1147-1151. |
| APA | Yin N.., Song Z.-F.., Xie W.., Wu Z.-B.., Yang X.-L.., Ge X.-L.., & Wang Y. (2008). Effects of APRV-BIPAP ventilation on lung recruitment/open maneuvers in piglets with acute lung injury. Chinese Journal of Emergency Medicine, 17(11), 1147-1151. |
| MLA | Yin N.,et al."Effects of APRV-BIPAP ventilation on lung recruitment/open maneuvers in piglets with acute lung injury".Chinese Journal of Emergency Medicine 17.11(2008):1147-1151. |
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