Tetraspanin CD53 promotes lymphocyte recirculation by stabilising L-selectin surface expression

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	Tetraspanin CD53 promotes lymphocyte recirculation by stabilising L-selectin surface expression
	Demaria, M. C.; Yeung, L.; Peeters, R.; Wee, J. L.; Mihaljcic, M.; Jones, E. L.; Nasa, Z.; Alderuccio, F.; Hall, P.; Smith, B. C.; Binger, K. J.; Hammerling, G.; Kwok, H. F.; Newman, A.; Ager, A.; van Spriel, A.; Hickey, M. J.; Wright, M. D.
	2020-05-01
Source Publication	iScience
ISSN	2589-0042
Pages	1011---
Abstract	Tetraspanins regulate key processes in immune cells; however, the function of the leukocyte-restricted tetraspanin, CD53 is unknown. Here we show that CD53 is essential for lymphocyte recirculation. Lymph nodes of Cd53-/- mice were smaller than wild-type mice due to a marked reduction in B cells and a 50% decrease in T cells. This reduced cellularity reflected an inability of Cd53-/- B and T cells to efficiently home to lymph nodes, due to the near absence of L-selectin from Cd53-/- B cells and reduced stability of L-selectin on Cd53-/- T cells. Further analyses, including on human lymphocytes, showed that CD53 stablises L-selectin surface expression, and may restrain L-selectin shedding via both ADAM17-dependent and -independent mechanisms. The disruption in lymphocyte recirculation in Cd53-/- mice led to impaired immune responses dependent on antigen delivery to lymph nodes. Together these findings demonstrate an essential role for CD53 in lymphocyte trafficking and immunity.
Keyword	Tetraspanin CD53 L-selectin Lymphocyte
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	50020
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Wright, M. D.
Recommended Citation GB/T 7714	Demaria, M. C.,Yeung, L.,Peeters, R.,et al. Tetraspanin CD53 promotes lymphocyte recirculation by stabilising L-selectin surface expression[J]. iScience, 2020, 1011---.
APA	Demaria, M. C.., Yeung, L.., Peeters, R.., Wee, J. L.., Mihaljcic, M.., Jones, E. L.., Nasa, Z.., Alderuccio, F.., Hall, P.., Smith, B. C.., Binger, K. J.., Hammerling, G.., Kwok, H. F.., Newman, A.., Ager, A.., van Spriel, A.., Hickey, M. J.., & Wright, M. D. (2020). Tetraspanin CD53 promotes lymphocyte recirculation by stabilising L-selectin surface expression. iScience, 1011---.
MLA	Demaria, M. C.,et al."Tetraspanin CD53 promotes lymphocyte recirculation by stabilising L-selectin surface expression".iScience (2020):1011---.

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