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A small molecule cryptotanshinone induces non-enzymatic NQO1-dependent necrosis in cancer cells through the JNK1/2/Iron/PARP/calcium pathway Journal article
Hou, Ying, Zhong, Bingling, Zhao, Lin, Wang, Heng, Zhu, Yanyan, Wang, Xianzhe, Zheng, Haoyi, Yu, Jie, Liu, Guokai, Wang, Xin, Martin-Garcia, Jose M., Chen, Xiuping. A small molecule cryptotanshinone induces non-enzymatic NQO1-dependent necrosis in cancer cells through the JNK1/2/Iron/PARP/calcium pathway[J]. Acta Pharmaceutica Sinica B, 2024.
Authors:  Hou, Ying;  Zhong, Bingling;  Zhao, Lin;  Wang, Heng;  Zhu, Yanyan; et al.
Favorite | TC[Scopus]:0  IF:14.7/14.1 | Submit date：2025/01/22
Nqo1  Cryptotanshinone  Iron  Ferroptosis  Nad++++ Depletion  Calcium  Targeted Therapy  Cancer  
YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer's disease Journal article
Jinfeng Sun, Fan Chen, Lingyu She, Yuqing Zeng, Hao Tang, Bozhi Ye, ZHENG WENHUA, Li Xiong, Liwei Li, Luyao Li, Qin Yu, Linjie Chen, Wei Wang, Guang Liang, Xia Zhao. YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer's disease[J]. Acta Pharmaceutica Sinica B, 2024.
Authors:  Jinfeng Sun;  Fan Chen;  Lingyu She;  Yuqing Zeng;  Hao Tang; et al.
Favorite | TC[Scopus]:0  IF:14.7/14.1 | Submit date：2024/08/31
Alzheimer’s Disease  Yod1  Myosin Heavy Chain 9  Microglia  Inflammation  Cognitive Dysfunction  Neurotoxicity  Synaptic Function  
Modeling on in vivo disposition and cellular transportation of RNA lipid nanoparticles via quantum mechanics/physiologically-based pharmacokinetic approaches Journal article
Wang, Wei, Deng, Shiwei, Lin, Jinzhong, Ouyang, Defang. Modeling on in vivo disposition and cellular transportation of RNA lipid nanoparticles via quantum mechanics/physiologically-based pharmacokinetic approaches[J]. Acta Pharmaceutica Sinica B, 2024, 14(10), 4591-4607.
Authors:  Wang, Wei;  Deng, Shiwei;  Lin, Jinzhong;  Ouyang, Defang
Favorite | TC[WOS]:1 TC[Scopus]:2  IF:14.7/14.1 | Submit date：2024/09/03
Lipid Nanoparticle  Rna  Ionizable Lipid  In Vivo Transportation  Endosomal Escape  Metabolism  Quantum Mechanics  Physiologically-based Pharmacokinetics  
Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke Journal article
Li, Ru, Wei, Riqing, Liu, Chenxin, Zhang, Keying, He, Sixiao, Liu, Zhifeng, Huang, Junhao, Tang, Youyong, An, Qiyuan, Lin, Ligen, Gan, Lishe, Zhao, Liying, Zou, Xiaoming, Wang, Fudi, Ping, Yuan, Ma, Qiang. Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke[J]. Acta Pharmaceutica Sinica B, 2024, 14(9), 3983-4000.
Authors:  Li, Ru;  Wei, Riqing;  Liu, Chenxin;  Zhang, Keying;  He, Sixiao; et al.
Favorite | TC[WOS]:6 TC[Scopus]:7  IF:14.7/14.1 | Submit date：2024/07/04
Heat Stroke  Liver Injury  Kupffer Cells  Ferroptosis  Heme Oxygenase 1  Phosphatidylinositol 4-kinase Beta  Nlrp3  Early Growth Response Factor 1  
Triple three-dimensional MS/MS spectrum facilitates quantitative ginsenosides-targeted sub-metabolome characterization in notoginseng Journal article
Zhang, Ke, Jia, Jinru, Li, Ting, Liu, Wenjing, Tu, Pengfei, Wan, Jian Bo, Li, Jun, Song, Yuelin. Triple three-dimensional MS/MS spectrum facilitates quantitative ginsenosides-targeted sub-metabolome characterization in notoginseng[J]. Acta Pharmaceutica Sinica B, 2024, 14(9), 4045-4058.
Authors:  Zhang, Ke;  Jia, Jinru;  Li, Ting;  Liu, Wenjing;  Tu, Pengfei; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:14.7/14.1 | Submit date：2024/06/05
Quantitative Sub-metabolome Characterization  Ginsenosides  Structural Identification  Notoginseng  Full Exciting Energy Ramp-ms3 Spectrum  
Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB Journal article
Linghu, Kegang, Cui, Wenqing, Li, Taiqin, Tuo, Yueting, Wang, Dasong, Pan, Huiqi, Zhang, Tian, Lin, Ligen, Yu, Hua, Hu, Xiaoxia, Li, Haiyang, Shen, Xiangchun. Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB[J]. Acta Pharmaceutica Sinica B, 2024, 14(8), 3561-3575.
Authors:  Linghu, Kegang;  Cui, Wenqing;  Li, Taiqin;  Tuo, Yueting;  Wang, Dasong; et al.
Favorite | TC[WOS]:6 TC[Scopus]:7  IF:14.7/14.1 | Submit date：2024/05/16
Α-methylene-γ-  Butyrolactone  Rheumatoid Arthritis  Nf-kb P65  Synovial  Microenvironment  Sesquiterpene Lactones  
Encoding and display technologies for combinatorial libraries in drug discovery: The coming of age from biology to therapy Review article
2024
Authors:  Fan, Yu;  Feng, Ruibing;  Zhang, Xinya;  Wang, Zhen Liang;  Xiong, Feng; et al.
Favorite | TC[WOS]:9 TC[Scopus]:8  IF:14.7/14.1 | Submit date：2024/05/16
Drug Screening  Dna-encoded Chemical Libraries  Phage Display  Peptide-encoded Chemical Libraries  Clinical Drugs  
ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction Journal article
Xu, Shiqiang, Ma, Qilian, Shen, Junwen, Li, Ningning, Sun, Shan, Wang, Nana, Chen, Yang, Dong, Chunsheng, Tam, Kin Yip, Prehn, Jochen H.M., Wang, Hongfeng, Ying, Zheng. ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction[J]. Acta Pharmaceutica Sinica B, 2024, 14(5), 2026-2038.
Authors:  Xu, Shiqiang;  Ma, Qilian;  Shen, Junwen;  Li, Ningning;  Sun, Shan; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:14.7/14.1 | Submit date：2024/05/16
Amyotrophic Lateral Sclerosis  Frontotemporal Dementia  C9orf72  Autophagy  Bcl2  Becn1/beclin 1  Dipeptide Repeat  Neurodegeneration  
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer Journal article
Jiang, Qiwei, Li, Yong, Cai, Songwang, Shi, Xingyuan, Yang, Yang, Xing, Zihao, He, Zhenjie, Wang, Shengte, Su, Yubin, Chen, Meiwan, Chen, Zhesheng, Shi, Zhi. GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer[J]. Acta Pharmaceutica Sinica B, 2024, 14(2), 698-711.
Authors:  Jiang, Qiwei;  Li, Yong;  Cai, Songwang;  Shi, Xingyuan;  Yang, Yang; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:14.7/14.1 | Submit date：2024/02/22
Gastric Cancer  Glul  N-cadherin  Β-catenin  Enzyme  
Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases Journal article
Deng, Wei Qing, Ye, Zi Han, Tang, Zhenghai, Zhang, Xiao Lei, Lu, Jin Jian. Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases[J]. Acta Pharmaceutica Sinica B, 2024.
Authors:  Deng, Wei Qing;  Ye, Zi Han;  Tang, Zhenghai;  Zhang, Xiao Lei;  Lu, Jin Jian
Favorite | TC[Scopus]:0  IF:14.7/14.1 | Submit date：2025/01/13
Application  Cd47  Clinical Data  Future Perspective  Mechanism  Non-cancer Disease  Phagocytosis  Preclinical Data