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Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents Journal article
Wang, Yingcai, Nie, Guangli, Wang, Xingshun, Ge, Wei, Zhang, Yandong. Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents[J]. Bioorganic and Medicinal Chemistry Letters, 2023, 96, 129505.
Authors:  Wang, Yingcai;  Nie, Guangli;  Wang, Xingshun;  Ge, Wei;  Zhang, Yandong
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:2.5/2.4 | Submit date：2023/12/04
Cancer  Dhx33  Rna Helicase  Inhibitor High Throughput Screening (Hts)  
Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors Journal article
Xu, Ting, Meng, Jie Ru, Cheng, Wanqing, Liu, Jia Zheng, Chu, Junyan, Zhang, Qian, Ma, Nannan, Bai, Li Ping, Guo, Yong. Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors[J]. Bioorganic and Medicinal Chemistry, 2022, 67.
Authors:  Xu, Ting;  Meng, Jie Ru;  Cheng, Wanqing;  Liu, Jia Zheng;  Chu, Junyan; et al.
Favorite | TC[WOS]:10 TC[Scopus]:10  IF:3.3/3.1 | Submit date：2023/01/30
1,3,4-oxadiazole  Honokiol  Sars-cov-2 Entry Inhibitor  Thioethers  Α-glucosidase Inhibitor  
Andrographolide derivative as antagonist of vitamin D receptor to induce lipidation of microtubule associate protein 1 light chain 3 (LC3) Journal article
Ding, Mo Yu, Peng, Yuran, Li, Feng, Li, Zheng Qing, Wang, Decai, Zhou, Guo Chun, Wang, Ying. Andrographolide derivative as antagonist of vitamin D receptor to induce lipidation of microtubule associate protein 1 light chain 3 (LC3)[J]. Bioorganic and Medicinal Chemistry, 2021, 51, 116505.
Authors:  Ding, Mo Yu;  Peng, Yuran;  Li, Feng;  Li, Zheng Qing;  Wang, Decai; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:3.3/3.1 | Submit date：2021/12/08
Andrographolide Derivative  Lipidation  Microtubule Associated Protein 1 Light Chain 3  Parkinsonism  Vitamin d Receptor  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
Zhang,Shao Lin, Yang,Zheng, Hu,Xiaohui, Tam,Kin Yip. Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships[J]. Bioorganic and Medicinal Chemistry Letters, 2018, 28(21), 3441-3445.
Authors:  Zhang,Shao Lin;  Yang,Zheng;  Hu,Xiaohui;  Tam,Kin Yip
Favorite | TC[WOS]:16 TC[Scopus]:16  IF:2.5/2.4 | Submit date：2021/03/04
Antiproliferative Activity  Dichloroacetophenone  Kinase Inhibition  Pyruvate Dehydrogenase Complex  Pyruvate Dehydrogenase Kinase  
C21-steroidal pregnane sapogenins and their derivatives as anti-inflammatory agents Journal article
Huang L.-J., Chen S.-R., Yuan C.-M., Gu W., Guo B.-J., Wang Y.-T., Wang Y., Hao X.-J.. C21-steroidal pregnane sapogenins and their derivatives as anti-inflammatory agents[J]. Bioorganic and Medicinal Chemistry, 2017, 25(13), 3512.
Authors:  Huang L.-J.;  Chen S.-R.;  Yuan C.-M.;  Gu W.;  Guo B.-J.; et al.
Favorite | TC[WOS]:15 TC[Scopus]:15  IF:3.3/3.1 | Submit date：2018/10/31
Anti-inflammation  C21-steroidal Pregnane Steroids  Nf-κb  Tlr  Traf6  
2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists Journal article
Vergelli C., Schepetkin I.A., Ciciani G., Cilibrizzi A., Crocetti L., Giovannoni M.P., Guerrini G., Iacovone A., Kirpotina L.N., Khlebnikov A.I., Ye R.D., Quinn M.T.. 2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists[J]. Bioorganic and Medicinal Chemistry, 2016, 24(11), 2530-2543.
Authors:  Vergelli C.;  Schepetkin I.A.;  Ciciani G.;  Cilibrizzi A.;  Crocetti L.; et al.
Favorite | TC[WOS]:21 TC[Scopus]:21 | Submit date：2018/11/07
Agonist  Ca2++ Mobilization  Formyl Peptide Receptor (Fpr)  Neutrophil  Pyridazin-3(2h)-one  
Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP Journal article
Zhang,Shao Lin, Yao,Huankai, Wang,Chenyin, Tam,Kin Y.. Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP[J]. Bioorganic and Medicinal Chemistry Letters, 2014, 24(21), 4963-4968.
Authors:  Zhang,Shao Lin;  Yao,Huankai;  Wang,Chenyin;  Tam,Kin Y.
Favorite | TC[WOS]:17 TC[Scopus]:17  IF:2.5/2.4 | Submit date：2021/03/04
Binding Affinity  Fluconazole  Fluorescence Spectrum  Human Serum Albumin  Molecular Docking  
Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP Journal article
Zhang S.-L., Yao H., Wang C., Tam K.Y.. Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP[J]. Bioorganic and Medicinal Chemistry Letters, 2014, 24(21), 4963-4968.
Authors:  Zhang S.-L.;  Yao H.;  Wang C.;  Tam K.Y.
Favorite | TC[WOS]:17 TC[Scopus]:17 | Submit date：2018/12/18
Binding Affinity  Fluconazole  Fluorescence Spectrum  Human Serum Albumin  Molecular Docking  
Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d] pyrimidine or furo[2,3-d]pyrimidine scaffold Journal article
Zhao A., Gao X., Wang Y., Ai J., Wang Y., Chen Y., Geng M., Zhang A.. Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d] pyrimidine or furo[2,3-d]pyrimidine scaffold[J]. Bioorganic and Medicinal Chemistry, 2011, 19(13), 3906-3918.
Authors:  Zhao A.;  Gao X.;  Wang Y.;  Ai J.;  Wang Y.; et al.
Favorite | TC[WOS]:39 TC[Scopus]:41 | Submit date：2019/01/16
Antitumor  C-met  Furo[2,3-d]Pyrimidine  Rtk  Thieno[2,3-d]Pyrimidine  
Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors Journal article
Jin H., Cianchetta G., Devasagayaraj A., Gu K., Marinelli B., Samala L., Scott S., Stouch T., Tunoori A., Wang Y., Zang Y., Zhang C., David Kimball S., Main A.J., Ding Z.-M., Sun W., Yang Q., Yu X.-Q., Powell D.R., Wilson A., Liu Q., Shi Z.-C.. Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors[J]. Bioorganic and Medicinal Chemistry Letters, 2009, 19(17), 5229-5232.
Authors:  Jin H.;  Cianchetta G.;  Devasagayaraj A.;  Gu K.;  Marinelli B.; et al.
Favorite | TC[WOS]:32 TC[Scopus]:31 | Submit date：2019/01/16
5-ht  Gastrointestinal Disorders  Tph1  Tryptophan Hydroxylase