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Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome Journal article
Pan, Zhijian, Yu, Chao Wu, Zhao, Chen, Shao, Min, Yang, Xuanjun, Liang, Xiaonan, Li, Haitao, Lu, Yucong, Ye, Qingqing, Chern, Ji Wang, Lu, Jiahong, Zhou, Hefeng, Lee, Simon Ming Yuen. Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome[J]. Toxicology and Applied Pharmacology, 2023, 480, 116745.
Authors:  Pan, Zhijian;  Yu, Chao Wu;  Zhao, Chen;  Shao, Min;  Yang, Xuanjun; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:3.3/3.6 | Submit date：2024/01/02
Immunoproteasome  J24335  Lmp7  Parkinson's Disease  Protein Degradation  Α-synuclein  
Bulleyaconitine A is a sensitive substrate and competitive inhibitor of CYP3A4: One of the possible explanations for clinical adverse reactions Journal article
Li, Xiaocui, Ou, Xiaowen, Ni, Jiadong, Xu, Yihong, Zuo, Huilin, Fu, Yu, Yang, Caihua, Zhao, Zhongxiang, Li, Na, Zhou, Hua, Zhang, Rong, Liu, Zhongqiu, Fu, Ling, Zhu, Lijun. Bulleyaconitine A is a sensitive substrate and competitive inhibitor of CYP3A4: One of the possible explanations for clinical adverse reactions[J]. Toxicology and Applied Pharmacology, 2022, 445.
Authors:  Li, Xiaocui;  Ou, Xiaowen;  Ni, Jiadong;  Xu, Yihong;  Zuo, Huilin; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:3.3/3.6 | Submit date：2023/01/30
Adverse Reaction  Bulleyaconitine a  Cytochrome P450 Enzymes  Drug-drug Interactions  Human Liver Microsomes  Metabolism  
Nannocystin Ax, a natural elongation factor 1α inhibitor from Nannocystis sp., suppresses epithelial-mesenchymal transition, adhesion and migration in lung cancer cells Journal article
Sun, Chong, Liu, Rong, Xia, Mengwei, Hou, Ying, Wang, Xumei, Lu, Jin jian, Liu, Bo, Chen, Xiuping. Nannocystin Ax, a natural elongation factor 1α inhibitor from Nannocystis sp., suppresses epithelial-mesenchymal transition, adhesion and migration in lung cancer cells[J]. Toxicology and Applied Pharmacology, 2021, 420, 115535.
Authors:  Sun, Chong;  Liu, Rong;  Xia, Mengwei;  Hou, Ying;  Wang, Xumei; et al.
Favorite | TC[WOS]:7 TC[Scopus]:6  IF:3.3/3.6 | Submit date：2021/12/08
Emt  Lung Cancer  Metastasis  Nannocystin Ax  
Natural alkaloid 8-oxo-epiberberine inhibited TGF-β1-triggred epithelial-mesenchymal transition by interfering Smad3 Journal article
Liu,Xin, Zhang,Yiying, ZHOU,Guang Ju, Hou,Ying, Kong,Qi, Lu,Jin Jian, Zhang,Qingwen, Chen,Xiuping. Natural alkaloid 8-oxo-epiberberine inhibited TGF-β1-triggred epithelial-mesenchymal transition by interfering Smad3[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 404, 115179.
Authors:  Liu,Xin;  Zhang,Yiying;  ZHOU,Guang Ju;  Hou,Ying;  Kong,Qi; et al.
Favorite | TC[WOS]:14 TC[Scopus]:14  IF:3.3/3.6 | Submit date：2021/03/01
Emt  Metastasis  Tgf-β1  Chinese Medicine  
Nagilactone D ameliorates experimental pulmonary fibrosis in vitro and in vivo via modulating TGF-β/Smad signaling pathway Journal article
Li,Ao, Xiao,Xiao, Feng,Zhe Ling, Chen,Xiuping, Liu,Li Juan, Lin,Li Gen, Lu,Jin Jian, Zhang,Le Le. Nagilactone D ameliorates experimental pulmonary fibrosis in vitro and in vivo via modulating TGF-β/Smad signaling pathway[J]. Toxicology and Applied Pharmacology, 2020, 389, 114882.
Authors:  Li,Ao;  Xiao,Xiao;  Feng,Zhe Ling;  Chen,Xiuping;  Liu,Li Juan; et al.
Favorite | TC[WOS]:19 TC[Scopus]:20  IF:3.3/3.6 | Submit date：2021/03/01
Bleomycin  Fibrotic Process  Nagilactone d  Pulmonary Fibrosis  Tgf-β1  
HHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator Journal article
Xiao,Xiao, Li,Shuo, Zhang,Xiaoxun, Lu,Jinjian, Wang,Weiguang, Zhou,Shijia, Zhang,Jingyao, Wang,Rui, Li,Ao. HHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator[J]. Toxicology and Applied Pharmacology, 2019, 373, 10-25.
Authors:  ; et al.
Favorite | TC[WOS]:8 TC[Scopus]:8  IF:3.3/3.6 | Submit date：2021/03/02
Breast Cancer Cells  Glucose Deprivation  Glucose-regulated Protein 78  Hhq-4  Unfolded Protein Response  
γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis Journal article
Anqi Wang, Fayang Zhou, Dan Li, Jin-Jian Lu, Yitao Wang, Ligen Lin. γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis[J]. Toxicology and Applied Pharmacology, 2019, 363, 142-153.
Authors:  Anqi Wang;  Fayang Zhou;  Dan Li;  Jin-Jian Lu;  Yitao Wang; et al.
Favorite | TC[WOS]:21 TC[Scopus]:24  IF:3.3/3.6 | Submit date：2018/12/28
Fibrogenesis  Hmgb1  Liver Fibrosis  Sirtuin 3  Superoxide  Γ-mangostin  
Dihydronortanshinone, a natural product, alleviates LPS-induced inflammatory response through NF-κB, mitochondrial ROS, and MAPK pathways Journal article
Xiaxia Wu, Hongwei Gao, Ying Hou, Jie Yu, Wen Sun, Ying Wang, Xiaoyan Chen, Yulin Feng, Qiong-ming Xu, Xiuping Chen. Dihydronortanshinone, a natural product, alleviates LPS-induced inflammatory response through NF-κB, mitochondrial ROS, and MAPK pathways[J]. Toxicology and Applied Pharmacology, 2018, 355, 1-8.
Authors:  Xiaxia Wu;  Hongwei Gao;  Ying Hou;  Jie Yu;  Wen Sun; et al.
Favorite | TC[WOS]:35 TC[Scopus]:38 | Submit date：2018/12/28
Dihydronortanshinone  Inflammation  Lps  Macrophage  
Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish Journal article
Zhou, Zhong-Yan, Huang, Bin, Li, Shang, Huang, Xiao-Hui, Tang, Jing-Yi, Kwan, Yiu Wa, Hoi, Pui Man, Lee, Simon Ming-Yuen. Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018, 350, 32-42.
Authors:  Zhou, Zhong-Yan;  Huang, Bin;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi; et al.
Favorite | TC[WOS]:34 TC[Scopus]:35  IF:3.3/3.6 | Submit date：2018/10/30
Sodium Tanshinone Iia Sulfonate  Salvia Miltiorrhiza  Hemorrhagic Stroke  Atorvastatin  Rock  
Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice Journal article
Guo, Yanling, Wu, Xiaxia, Wu, Qin, Lu, Yuanfu, Shi, Jingshan, Chen, Xiuping. Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018, 344, 35-45.
Authors:  Guo, Yanling;  Wu, Xiaxia;  Wu, Qin;  Lu, Yuanfu;  Shi, Jingshan; et al.
Favorite | TC[WOS]:49 TC[Scopus]:53  IF:3.3/3.6 | Submit date：2018/10/30
15,16-dihydrotanshinone i  Ulcerative Colitis  Inflammation  Necroptosis