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In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: Identifying sinensetin as a novel antiangiogenesis agent Journal article
n Kei Lam, Deepa Alex, You-Hua Wang, Ping Liu, Ai-Lin Liu, Guan-Hua Du, Simon Ming Yuen Lee. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: Identifying sinensetin as a novel antiangiogenesis agent[J]. Molecular Nutrition and Food Research, 2012, 56(6), 945.
Authors:  n Kei Lam;  Deepa Alex;  You-Hua Wang;  Ping Liu;  Ai-Lin Liu; et al.
Favorite | TC[WOS]:70 TC[Scopus]:76 | Submit date：2018/10/30
Angiogenesis  Polymethoxylated Flavonoid  Sinensetin  Structure-activity Relationship  Zebrafish  
Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae Journal article
Li, ZH (Li, Zhen Hua), Alex, D (Alex, Deepa), Siu, SO (Siu, Shiu On), Chu, IK (Chu, Ivan Keung), Renn, J (Renn, Joerg), Winkler, C (Winkler, Christoph), Lou, S (Lou, Shaoke), Tsui, SKW (Tsui, Stephen Kwok-Wing), Zhao, HY (Zhao, Hai Yu), Yan, WR (Yan, Wendy Ru), Mahady, GB (Mahady, Gail B.), Li, GH (Li, Guo Hui), Kwan, YW (Kwan, Yiu Wa), Wang, YT (Wang, Yi Tao), Lee, SMY (Lee, Simon Ming-Yuen). Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae[J]. MOLECULAR BIOSYSTEMS, 2011, 7(7), 2128-2138.
Authors:  Li, ZH (Li, Zhen Hua);  Alex, D (Alex, Deepa);  Siu, SO (Siu, Shiu On);  Chu, IK (Chu, Ivan Keung);  Renn, J (Renn, Joerg); et al.
View | Adobe PDF | Favorite | TC[WOS]:43 TC[Scopus]:52  IF:3.336/2.986 | Submit date：2018/11/01
Animal-models  Flavonoids  Quercetin  Bone  Fluorescence  Absorption  Proteome  Swim  
Nobiletin, a polymethoxylated flavonoid from citrus, shows anti-angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model Journal article
Kai Heng Lam, Deepa Alex, In Kei Lam, Stephen Kwok Wing Tsui, Zi Feng Yang, Simon Ming Yuen Lee. Nobiletin, a polymethoxylated flavonoid from citrus, shows anti-angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model[J]. Journal of Cellular Biochemistry, 2011, 112(11), 3313.
Authors:  Kai Heng Lam;  Deepa Alex;  In Kei Lam;  Stephen Kwok Wing Tsui;  Zi Feng Yang; et al.
Favorite | TC[WOS]:58 TC[Scopus]:67 | Submit date：2018/10/30
Angiogenesis  Anti-inflammatory  Cell Cycle  Flavonoid  Nobiletin  Zebrafish  
Inhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4′-trimethoxystilbene Journal article
Yan-Hui Deng, Deepa Alex, He-Qing Huang, Nan Wang, Nan Yu, Yi-Tao Wang, George P. H. Leung, Simon Ming-Yuen Lee. Inhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4′-trimethoxystilbene[J]. Phytotherapy Research, 2011, 25(3), 451.
Authors:  Yan-Hui Deng;  Deepa Alex;  He-Qing Huang;  Nan Wang;  Nan Yu; et al.
Favorite | TC[WOS]:64 TC[Scopus]:72 | Submit date：2018/10/30
Cell Adhesion Molecules  Inflammation  Nf-′b  Resveratrol  Stilbene  
Indirubin shows anti-angiogenic activity in an in vivo zebrafish model and an in vitro HUVEC model Journal article
Deepa Alex, In Kei Lam, ZhiXiu Lin, Simon Ming Yuen Lee. Indirubin shows anti-angiogenic activity in an in vivo zebrafish model and an in vitro HUVEC model[J]. Journal of Ethnopharmacology, 2010, 131(2), 242.
Authors:  Deepa Alex;  In Kei Lam;  ZhiXiu Lin;  Simon Ming Yuen Lee
Favorite | TC[WOS]:41 TC[Scopus]:47 | Submit date：2018/10/30
Anti-angiogenesis  Apoptosis  Indirubin  Zebrafish  
Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC Journal article
Jing Yan Tang, Shang Li, Zhen Hua Li, Zai Jun Zhang, Guang Hu, Lorita Chi Veng Cheang, Deepa Alex, Maggie Pui Man Hoi, Yiu Wa Kwan, Shun Wan Chan, George Pak Heng Leung, Simon Ming Yuen Lee. Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC[J]. PLoS ONE, 2010, 5(7).
Authors:  Jing Yan Tang;  Shang Li;  Zhen Hua Li;  Zai Jun Zhang;  Guang Hu; et al.
Favorite | TC[WOS]:110 TC[Scopus]:120 | Submit date：2018/10/30
Resveratrol derivative, trans-3,5,4′-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation Journal article
Deepa Alex, Emilia Conceição Leong, Zai-Jun Zhang, Gloria Tse Ho Yan, Shuk-Han Cheng, Chi-Weng Leong, Zhen-Hua Li, Kai-Heng Lam, Shun-Wan Chan, Simon Ming-Yuen Lee. Resveratrol derivative, trans-3,5,4′-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation[J]. Journal of Cellular Biochemistry, 2010, 109(2), 339.
Authors:  Deepa Alex;  Emilia Conceição Leong;  Zai-Jun Zhang;  Gloria Tse Ho Yan;  Shuk-Han Cheng; et al.
Favorite | TC[WOS]:54 TC[Scopus]:59 | Submit date：2018/10/30
3,5,4′-trimethoxystilbene  Angiogenesis  Cell Cycle  Huvec  Vegfr2  Zebrafish