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An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease Journal article
Ju,Yaojun, Chakravarty,Harapriya, Tam,Kin Yip. An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease[J]. ACS Chemical Neuroscience, 2020, 11(20), 3346-3357.
Authors:  Ju,Yaojun;  Chakravarty,Harapriya;  Tam,Kin Yip
Favorite | TC[WOS]:6 TC[Scopus]:6  IF:4.1/4.3 | Submit date：2021/03/04
Alzheimer's Disease  Amyloid Beta  Cholinesterase  Dual Inhibition  
Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives Journal article
Chakravarty,Harapriya, Ju,Yaojun, Chen,Wen Hua, Tam,Kin Y.. Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives[J]. DRUG DEVELOPMENT RESEARCH, 2020, 81(2), 242-255.
Authors:  Chakravarty,Harapriya;  Ju,Yaojun;  Chen,Wen Hua;  Tam,Kin Y.
Favorite | TC[WOS]:9 TC[Scopus]:9  IF:3.5/4.0 | Submit date：2021/03/04
Acetylcholinesterase  Alzheimer's Disease  Amyloid Beta  Butyrylcholinesterase  Dual Target Inhibitor  Isoquinolinium  Pyridinium  
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
Zhang, Shao-Lin, Yang, Zheng, Hu, Xiaohui, Chakravarty, Harapriya, Tam, Kin Yip. Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 123, 43-55.
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite | TC[WOS]:15 TC[Scopus]:15  IF:4.3/4.2 | Submit date：2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming  
Astemizole inhibits mTOR signaling and angiogenesis by blocking cholesterol trafficking Journal article
Lyu,Junfang, Yang,Eun Ju, Head,Sarah A., Ai,Nana, Zhang,Baoyuan, Wu,Changjie, Li,Ruo Jing, Liu,Yifan, Chakravarty,Harapriya, Zhang,Shaolin, Tam,Kin Yip, Dang,Yongjun, Kwon,Ho Jeong, Ge,Wei, Liu,Jun O., Shim,Joong Sup. Astemizole inhibits mTOR signaling and angiogenesis by blocking cholesterol trafficking[J]. International Journal of Biological Sciences, 2018, 14(10), 1175-1185.
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Head,Sarah A.;  Ai,Nana;  Zhang,Baoyuan; et al.
Favorite | TC[WOS]:21 TC[Scopus]:22  IF:8.2/8.3 | Submit date：2021/03/02
Angiogenesis  Astemizole  Cholesterol Trafficking  Mtor  Npc1  
Identification of a Wells-Dawson polyoxometalate-based AP-2 gamma inhibitor with pro-apoptotic activity Journal article
Hu, Jiamiao, Tan, Si Kee, Lim, Michelle Gek Liang, Chang, Shie Hong, Cui, Guimei, Liu, Shanshan, Narasimhan, Kamesh, New, Siu Yee, Wang, Xuecong, Chen, Congling, Chakravarty, Harapriya, Kolatkar, Prasanna R., Tam, Kin Yip, Lu, Qian, Su, Xiaodi, Jauch, Ralf, Cheung, Edwin. Identification of a Wells-Dawson polyoxometalate-based AP-2 gamma inhibitor with pro-apoptotic activity[J]. BIOCHEMICAL JOURNAL, 2018, 475(11), 1965-1977.
Authors:  Hu, Jiamiao;  Tan, Si Kee;  Lim, Michelle Gek Liang;  Chang, Shie Hong;  Cui, Guimei; et al.
Favorite | TC[WOS]:9 TC[Scopus]:10  IF:4.4/3.7 | Submit date：2018/10/30
Ap-2γ  Breast Cancer  Fluorescent Anisotropic  Polyoxometalate  
Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking Journal article
Lyu, Junfang, Yang, Eun Ju, Head, Sarah A., Ai, Nana, Zhang, Baoyuan, Wu, Changjie, Li, Ruo-Jing, Liu, Yifan, Chakravarty, Harapriya, Zhang, Shaolin, Tam, Kin Yip, Dang, Yongjun, Kwon, Ho Jeong, Gel, Wei, Liu, Jun O., Shim, Joong Sup. Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018, 14(10), 1175-1185.
Authors:  Lyu, Junfang;  Yang, Eun Ju;  Head, Sarah A.;  Ai, Nana;  Zhang, Baoyuan; et al.
Favorite | TC[WOS]:21 TC[Scopus]:22  IF:8.2/8.3 | Submit date：2018/10/30
Cholesterol Trafficking  Angiogenesis  Astemizole  Npc1  Mtor