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Medium acidosis drives cardiac differentiation during mesendoderm cell fate specification from human pluripotent stem cells Journal article
Weiwei Liu, Hsun-Ting Hsieh, Ziqing He, Xia Xiao, Chengcheng Song, En Xin Lee, Ji Dong, Chon Lok Lei, Jiaxian Wang, Guokai Chen. Medium acidosis drives cardiac differentiation during mesendoderm cell fate specification from human pluripotent stem cells[J]. Stem Cell Reports, 2024, 19(9), 1304-1319.
Authors:  Weiwei Liu;  Hsun-Ting Hsieh;  Ziqing He;  Xia Xiao;  Chengcheng Song; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:5.9/5.9 | Submit date：2024/08/26
Comprehensive classification of TP53 somatic missense variants based on their impact on p53 structural stability Journal article
Benjamin Tam, Philip Naderev P. Lagniton, Mariano da Luz, Bojin Zhao, Siddharth Sinha, Chon Lok Lei, San Ming Wang. Comprehensive classification of TP53 somatic missense variants based on their impact on p53 structural stability[J]. Briefings in Bioinformatics, 2024, 25(5), bbae400.
Authors:  Benjamin Tam;  Philip Naderev P. Lagniton;  Mariano da Luz;  Bojin Zhao;  Siddharth Sinha; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:6.8/7.9 | Submit date：2024/08/07
Ramachandran Plot  Molecular Dynamics Simulations  Tp53  Somatic Missense Variants  
Ten simple rules for training scientists to make better software Journal article
Gallagher, Kit, Creswell, Richard, Lambert, Ben, Robinson, Martin, Lei, Chon Lok, Mirams, Gary R., Gavaghan, David J.. Ten simple rules for training scientists to make better software[J]. PLOS COMPUTATIONAL BIOLOGY, 2024, 20(9), e1012410.
Authors:  Gallagher, Kit;  Creswell, Richard;  Lambert, Ben;  Robinson, Martin;  Lei, Chon Lok; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:3.8/4.3 | Submit date：2024/10/10
The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk Journal article
Lei, Chon Lok, Whittaker, Dominic G., Mirams, Gary R.. The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk[J]. British Journal of Pharmacology, 2024, 181(7), 987-1004.
Authors:  Lei, Chon Lok;  Whittaker, Dominic G.;  Mirams, Gary R.
Favorite | TC[WOS]:2 TC[Scopus]:1  IF:6.8/7.4 | Submit date：2024/02/22
Binding Mechanism  Cipa  Herg  Mathematical Modelling  Proarrhythmic Risk  Safety Pharmacology  Torsade  
Understanding the impact of numerical solvers on inference for differential equation models Journal article
Creswell, Richard, Shepherd, Katherine M., Lambert, Ben, Mirams, Gary R., Lei, Chon Lok, Tavener, Simon, Robinson, Martin, Gavaghan, David J.. Understanding the impact of numerical solvers on inference for differential equation models[J]. Journal of the Royal Society Interface, 2024, 21(212), 20230369.
Authors:  Creswell, Richard;  Shepherd, Katherine M.;  Lambert, Ben;  Mirams, Gary R.;  Lei, Chon Lok; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:3.7/4.0 | Submit date：2024/04/02
Bayesian Statistics  Compartmental Models  Hydrological Modelling  Inference  Ordinary Differential Equations  Truncation Error  
Corrigendum: Heterologous vaccination with inactivated vaccine and mRNA vaccine augments antibodies against both spike and nucleocapsid proteins of SARS-CoV-2: a local study in Macao (Frontiers in Immunology, (2023), 14, (1131985), 10.3389/fimmu.2023.1131985) Other
2024-02-06
Authors:  Ng, Hoi Man;  Lei, Chon Lok;  Fu, Siyi;  Li, Enqin;  Leong, Sek In; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0 | Submit date：2024/05/16
Antibodies  Heterologous Vaccinations  Inactivated Vaccine  Macao  Mrna Vaccine  Nucleocapsid Proteins  Sars-cov-2  Spike Proteins  
Classification of MLH1 Missense VUS Using Protein Structure-Based Deep Learning-Ramachandran Plot-Molecular Dynamics Simulations Method Journal article
Tam, Benjamin, Qin, Zixin, Zhao, Bojin, Sinha, Siddharth, Lei, Chon Lok, Wang, San Ming. Classification of MLH1 Missense VUS Using Protein Structure-Based Deep Learning-Ramachandran Plot-Molecular Dynamics Simulations Method[J]. International Journal of Molecular Sciences, 2024, 25(2), 850.
Authors:  Tam, Benjamin;  Qin, Zixin;  Zhao, Bojin;  Sinha, Siddharth;  Lei, Chon Lok; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:4.9/5.6 | Submit date：2024/02/22
Autoencoder  Deep Learning  Mlh1  Molecular Dynamics Simulation  Neural Network  Ramachandran Plot  Vus  
Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics Journal article
Shuttleworth, Joseph G., Lei, Chon Lok, Whittaker, Dominic G., Windley, Monique J., Hill, Adam P., Preston, Simon P., Mirams, Gary R.. Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics[J]. Bulletin of Mathematical Biology, 2024, 86(1), 2.
Authors:  Shuttleworth, Joseph G.;  Lei, Chon Lok;  Whittaker, Dominic G.;  Windley, Monique J.;  Hill, Adam P.; et al.
Favorite | TC[WOS]:2 TC[Scopus]:4  IF:2.0/2.1 | Submit date：2024/02/22
Discrepancy  Experimental Design  Ion Channel  Mathematical Model  Misspecification  Uncertainty Quantification  
What we learned from lifting COVID-19 restrictions in Macao in December 2022 Journal article
Lei,Chon Lok, Ng,Hoi Man, Qin,Guihui, Yeung,Cheung Kwan, Lei,Chon Leng, Xu,Ren He. What we learned from lifting COVID-19 restrictions in Macao in December 2022[J]. International Journal of Biological Sciences, 2023, 19(16), 5337-5339.
Authors:  Lei,Chon Lok;  Ng,Hoi Man;  Qin,Guihui;  Yeung,Cheung Kwan;  Lei,Chon Leng; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:8.2/8.3 | Submit date：2023/08/30
Vaccines  
Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings Journal article
Alexander P Clark, Michael Clerx, Siyu Wei, Chon Lok Lei, Teun P de Boer, Gary R Mirams, David J Christini, Trine Krogh-Madsen. Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings[J]. EUROPACE, 2023, 25(9), euad243.
Authors:  Alexander P Clark;  Michael Clerx;  Siyu Wei;  Chon Lok Lei;  Teun P de Boer; et al.
Favorite | TC[WOS]:4 TC[Scopus]:5  IF:7.9/6.3 | Submit date：2023/09/04
Arrhythmias  Computer Simulation  Induced Pluripotent Stem Cells  Ion Channels  Patch Clamp