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Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of MTOR signaling and angiogenesis Journal article
Head S.A., Shi W.Q., Yang E.J., Nacev B.A., Hong S.Y., Pasunooti K.K., Li R.-J., Shim J.S., Liu J.O.. Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of MTOR signaling and angiogenesis[J]. ACS Chemical Biology, 2017, 12(1), 174.
Authors:  Head S.A.;  Shi W.Q.;  Yang E.J.;  Nacev B.A.;  Hong S.Y.; et al.
Favorite | TC[WOS]:65 TC[Scopus]:66 | Submit date：2018/10/30
Divergence of antiangiogenic activity and hepatotoxicity of different stereoisomers of itraconazole Journal article
Shim J.S., Li R.-J., Bumpus N.N., Head S.A., Pasunooti K.K., Yang E.J., Lv J., Shi W., Liu J.O.. Divergence of antiangiogenic activity and hepatotoxicity of different stereoisomers of itraconazole[J]. Clinical Cancer Research, 2016, 22(11), 2709-2720.
Authors:  Shim J.S.;  Li R.-J.;  Bumpus N.N.;  Head S.A.;  Pasunooti K.K.; et al.
Favorite | TC[WOS]:12 TC[Scopus]:12 | Submit date：2019/01/15
Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism Journal article
Shim J.S., Li R.-J., Lv J., Head S.A., Yang E.J., Liu J.O.. Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism[J]. Cancer Letters, 2015, 362(1), 106-115.
Authors:  Shim J.S.;  Li R.-J.;  Lv J.;  Head S.A.;  Yang E.J.; et al.
Favorite | TC[WOS]:25 TC[Scopus]:25 | Submit date：2019/01/15
Angiogenesis  Cholesterol Trafficking  Selective Estrogen Receptor Modulator  Tamoxifen  
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells Journal article
Head S.A., Shi W., Zhao L., Gorshkov K., Pasunooti K., Chen Y., Deng Z., Li R.-J., Shim J.S., Tan W., Hartung T., Zhang J., Zhao Y., Colombini M., Liu J.O.. Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells[J]. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112(52), E7276.
Authors:  Head S.A.;  Shi W.;  Zhao L.;  Gorshkov K.;  Pasunooti K.; et al.
Favorite | TC[WOS]:85 TC[Scopus]:91 | Submit date：2018/10/30
Angiogenesis  Itraconazole  Metabolism  Mitochondria  Vdac1