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Tulipalin A suppressed the pro-inflammatory polarization of M1 macrophage and mitigated the acute lung injury in mice via interference DNA binding activity of NF-κB Journal article
Linghu, Ke Gang, Tuo, Yue Ting, Cui, Wen Qing, Li, Tai Qin, Wang, Da Song, Zhang, Ya Ya, Zhang, Jian, Zhang, Tian, Wang, Yu E., Yu, Hua, Shen, Xiang Chun, Li, Hai Yang. Tulipalin A suppressed the pro-inflammatory polarization of M1 macrophage and mitigated the acute lung injury in mice via interference DNA binding activity of NF-κB[J]. European Journal of Pharmacology, 2024, 984, 177034.
Authors:  Linghu, Ke Gang;  Tuo, Yue Ting;  Cui, Wen Qing;  Li, Tai Qin;  Wang, Da Song; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:4.2/4.3 | Submit date：2024/11/05
Tulipalin a  Acute Lung Injury  M1 Polarization  Macrophage  Dna Binding Activity  Nf-κb  
Ganweikang extract protects hepatocytes from oxidative injury by activating Nrf2/HO-1 and MAPKs pathways Journal article
Xiao Linxuan, Zhao Mingming, Linghu Ke-Gang, Wu Guoping, Zhang Tian, Chen Chengyu, Guan Jianli, Cao Zhiming, HU YUANJIA, Yu Hua. Ganweikang extract protects hepatocytes from oxidative injury by activating Nrf2/HO-1 and MAPKs pathways[J]. Fitoterapia, 2024, 178, 106146.
Authors:  Xiao Linxuan;  Zhao Mingming;  Linghu Ke-Gang;  Wu Guoping;  Zhang Tian; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:2.5/2.7 | Submit date：2024/08/29
Acute Hepatic Injury  Ganweikang  Hepato-protection  Mapks  Nrf2/ho-1  
Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy Journal article
Linghu, Ke-Gang, Zhang, Tian, Zhang, Guang-Tao, Lv, Peng, Zhang, Wenjun, Zhao, Guanding, Xiong, Shihong, Zhao, Mingming, Chen, Meiwan, HU YUANJIA, Zhang, Changsheng, Yu, Hua. Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy[J]. Journal of Pharmaceutical Analysis, 2024, 14(3), 401-415.
Authors:  Linghu, Ke-Gang;  Zhang, Tian;  Zhang, Guang-Tao;  Lv, Peng;  Zhang, Wenjun; et al.
Favorite | TC[WOS]:6 TC[Scopus]:9  IF:6.1/6.8 | Submit date：2024/01/02
Deoxynyboquinone  Anti-inflammation  Target  Keap1/nrf2  Alkylation  Ubiquitination  
Expanding potential targets of herbal chemicals by node2vec based on herb–drug interactions Journal article
Dai-yan Zhang, Wen-qing Cui, Ling Hou, Jing Yang, Li-yang Lyu, Ze-yu Wang, Ke-Gang Linghu, Wen-bin He, Hua Yu, Yuan-jia Hu. Expanding potential targets of herbal chemicals by node2vec based on herb–drug interactions[J]. Chinese Medicine (United Kingdom), 2023, 18(1), 64.
Authors:  Dai-yan Zhang;  Wen-qing Cui;  Ling Hou;  Jing Yang;  Li-yang Lyu; et al.
Favorite | TC[WOS]:1 TC[Scopus]:2  IF:5.3/5.5 | Submit date：2023/08/03
Cardiovascular Disease  Herb–drug Interaction  Link Prediction  Node2vec  Traditional Medicine  
Leocarpinolide B Attenuates Collagen Type II-Induced Arthritis by Inhibiting DNA Binding Activity of NF-κB Journal article
Linghu, Ke Gang, Zhao, Guan Ding, Zhang, Dai Yan, Xiong, Shi Hang, Wu, Guo Ping, Shen, Li Yu, Cui, Wen Qing, Zhang, Tian, Hu, Yuan Jia, Guo, Bing, Shen, Xiang Chun, Yu, Hua. Leocarpinolide B Attenuates Collagen Type II-Induced Arthritis by Inhibiting DNA Binding Activity of NF-κB[J]. Molecules (Basel, Switzerland), 2023, 28(10), 4241.
Authors:  Linghu, Ke Gang;  Zhao, Guan Ding;  Zhang, Dai Yan;  Xiong, Shi Hang;  Wu, Guo Ping; et al.
Favorite | TC[WOS]:4 TC[Scopus]:4  IF:4.2/4.6 | Submit date：2023/06/05
Leocarpinolide b  Nf-κb P65  Rheumatoid Arthritis  Sesquiterpene Lactone  Synovitis  
The “whole ingredients extract” of Astragali Radix improves the symptoms of dextran sulfate sodium-induced ulcerative colitis in mice through systemic immunomodulation Journal article
Linghu, Ke Gang, Ma, Qiushuo, Xiong, Shi Hang, Zhao, Mingming, Chen, Qiling, Xu, Wen, Chen, Meiwan, Zhang, Jian Ye, Hu, Yuanjia, Xu, Wei, Yu, Hua. The “whole ingredients extract” of Astragali Radix improves the symptoms of dextran sulfate sodium-induced ulcerative colitis in mice through systemic immunomodulation[J]. Chinese Medicine (United Kingdom), 2022, 17(1), 109.
Authors:  Linghu, Ke Gang;  Ma, Qiushuo;  Xiong, Shi Hang;  Zhao, Mingming;  Chen, Qiling; et al.
Favorite | TC[WOS]:3 TC[Scopus]:4  IF:5.3/5.5 | Submit date：2023/01/30
Astragali Radix  Whole Ingredients Extract  Immunomodulation  Ulcerative Colitis  
Anti-inflammatory/anti-oxidant properties and the UPLC-QTOF/MS-based metabolomics discrimination of three yellow camellia species Journal article
Zhao, Mingming, Linghu, Ke-Gang, Xiao, Linxuan, Hua, Tianyi, Zhao, Guanding, Chen, Qiling, Xiong, Shihang, Shen, Liyu, Yu, Jinyu, Hou, Xiaotao, Hao, Erwei, Du, Zhengcai, Deng, Jiagang, Bai, Gang, Chen, Xiaojia, Li, Ling, Li, Peng, Yu, Hua. Anti-inflammatory/anti-oxidant properties and the UPLC-QTOF/MS-based metabolomics discrimination of three yellow camellia species[J]. Food Research International, 2022, 160, 111628.
Authors:  Zhao, Mingming;  Linghu, Ke-Gang;  Xiao, Linxuan;  Hua, Tianyi;  Zhao, Guanding; et al.
Favorite | TC[WOS]:12 TC[Scopus]:11  IF:7.0/7.4 | Submit date：2022/08/18
Yellow Camellias  Discrimination  Metabolomics  Fingerprint  Anti -inflammation  Anti -oxidant  
Comprehensive comparison on the anti-inflammation and GC-MS-based metabolomics discrimination between Bupleuri chinense DC. and B. scorzonerifolium Willd Journal article
Zhao, Mingming, Xiao, Linxuan, Linghu, Ke Gang, Zhao, Guanding, Chen, Qiling, Shen, Liyu, Dar, Parsa, Chen, Meiwan, Hu, Yuan, Zhang, Jinming, Yu, Hua. Comprehensive comparison on the anti-inflammation and GC-MS-based metabolomics discrimination between Bupleuri chinense DC. and B. scorzonerifolium Willd[J]. Frontiers in Pharmacology, 2022, 13, 1005011.
Authors:  Zhao, Mingming;  Xiao, Linxuan;  Linghu, Ke Gang;  Zhao, Guanding;  Chen, Qiling; et al.
Favorite | TC[WOS]:6 TC[Scopus]:7  IF:4.4/5.0 | Submit date：2023/01/30
Anti-infammation  Bupleuri Radix  Gc-ms  Metabolomics  Species Discrimination  
Brij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs Journal article
Xiong, Wei, Xiong, Shi Hang, Chen, Qi Ling, Linghu, Ke Gang, Zhao, Guan Ding, Chu, John M.T., Wong, Gordon T.C., Li, Juan, Hu, Yuan Jia, Wang, Yi Tao, Yu, Hua. Brij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs[J]. Carbohydrate Polymers, 2021, 266.
Authors:  Xiong, Wei;  Xiong, Shi Hang;  Chen, Qi Ling;  Linghu, Ke Gang;  Zhao, Guan Ding; et al.
Favorite | TC[WOS]:15 TC[Scopus]:18  IF:10.7/10.2 | Submit date：2021/09/13
Berberine  Brij-grafted-chitosan  Diabetic Kidney Disease  Oral Nanocarrier  P-glycoprotein  
Botany, traditional use, phytochemistry, pharmacology and toxicology of Sigesbeckiae Herba (Xixiancao): a review Review article
2021
Authors:  Tao,Hong Xun;  Zhao,Guan Ding;  Linghu,Ke Gang;  Xiong,Wei;  Sang,Wei; et al.
Favorite | TC[WOS]:10 TC[Scopus]:9  IF:7.3/7.9 | Submit date：2021/03/02
Sigesbeckiae Herba  Traditional Use  Phytochemistry  Pharmacology  Toxicology