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Discovery of potent LRRK2 inhibitors by ensemble virtual screening strategy and bioactivity evaluation Journal article
Gong, Xiaoqing, Li, Shuli, Huang, Junli, Tan, Shuoyan, Zhang, Qianqian, Tian, Yanan, Li, Qin, Wang, Lingling, Tong, Henry H.Y., Yao, Xiaojun, Chen, Chunxia, Lee, Simon Ming Yuen, Liu, Huanxiang. Discovery of potent LRRK2 inhibitors by ensemble virtual screening strategy and bioactivity evaluation[J]. European Journal of Medicinal Chemistry, 2024, 279, 116812.
Authors:  Gong, Xiaoqing;  Li, Shuli;  Huang, Junli;  Tan, Shuoyan;  Zhang, Qianqian; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:6.0/6.1 | Submit date：2024/10/10
Fingerprint  Lrrk2  Molecular Docking  Pharmacophore  Virtual Screening  Zebrafish  
Medicinal plants and natural products for treating overactive bladder Journal article
Chen, Huanxian, Hoi, Maggie Pui Man, Lee, Simon Ming Yuen. Medicinal plants and natural products for treating overactive bladder[J]. Chinese Medicine (United Kingdom), 2024, 19(1).
Authors:  Chen, Huanxian;  Hoi, Maggie Pui Man;  Lee, Simon Ming Yuen
Favorite | TC[WOS]:1 TC[Scopus]:1 | Submit date：2024/09/03
Medicinal plants  Natural products  Overactive bladder  
Oxyphylla A exerts antiparkinsonian effects by ameliorating 6-OHDA-induced mitochondrial dysfunction and dyskinesia in vitro and in vivo Journal article
Shao, Min, Zhao, Chen, Pan, Zhijian, Yang, Xuanjun, Gao, Cheng, Kam, Gloria Hio Cheng, Zhou, Hefeng, Lee, Simon Ming Yuen. Oxyphylla A exerts antiparkinsonian effects by ameliorating 6-OHDA-induced mitochondrial dysfunction and dyskinesia in vitro and in vivo[J]. Chemico-Biological Interactions, 2024, 403, 111224.
Authors:  Shao, Min;  Zhao, Chen;  Pan, Zhijian;  Yang, Xuanjun;  Gao, Cheng; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:4.7/4.6 | Submit date：2024/10/10
6-ohda  Mitochondria  Neuroprotection  Oxyphylla a  Parkinson's Disease  Target Prediction  
A NIR iridium(III) complex-based luminescence probe for imaging mitochondria pyruvate dehydrogenase kinase 1 in triple-negative breast cancer cells Journal article
Jing, Shaozhen, Song, Ying Qi, Liu, Jingqi, Zhao, Chen, Wang, Ling, Chan, Daniel Shiu Hin, Wong, Chun Yuen, Lee, Simon Ming Yuen, Wang, Jing, Leung, Chung Hang, Wang, Wanhe. A NIR iridium(III) complex-based luminescence probe for imaging mitochondria pyruvate dehydrogenase kinase 1 in triple-negative breast cancer cells[J]. Sensors and Actuators B: Chemical, 2024, 418, 136265.
Authors:  Jing, Shaozhen;  Song, Ying Qi;  Liu, Jingqi;  Zhao, Chen;  Wang, Ling; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:8.0/7.0 | Submit date：2024/08/05
Breast Cancer  Dichloroacetic Acid (Dca)  Iridium(Iii) Complex  Mitochondrial Targeting  Nir Imaging  Pyruvate Dehydrogenase Kinase 1 (Pdk1)  
Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson's disease models Journal article
Guo, Baojian, Zheng, Chengyou, Cao, Jie, Luo, Fangcheng, Li, Haitao, Hu, Shengquan, Mingyuan Lee, Simon, Yang, Xifei, Zhang, Gaoxiao, Zhang, Zaijun, Sun, Yewei, Wang, Yuqiang. Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson's disease models[J]. Journal of Advanced Research, 2024, 64, 195-211.
Authors:  Guo, Baojian;  Zheng, Chengyou;  Cao, Jie;  Luo, Fangcheng;  Li, Haitao; et al.
Favorite | TC[WOS]:4 TC[Scopus]:4  IF:11.4/11.0 | Submit date：2024/02/22
Nuclear Factor Erythroid-2-related Factor 2  Parkinson's Disease  Peroxisome Proliferator-activated Receptor γ Co-activator 1α  Tetramethylpyrazine Nitrone  
Flavor compound geraniol induces inhibited nutrient utilization and developmental toxicity on embryonic–larval zebrafish Journal article
Luo, Yumin, Han, Run, Ren, Zhengyu, Ai, Nana, Yu, Shaowen, Lee, Simon Ming Yuen, Ge, Wei, Chen, Ying, Zheng, Ying. Flavor compound geraniol induces inhibited nutrient utilization and developmental toxicity on embryonic–larval zebrafish[J]. Food Frontiers, 2024.
Authors:  Luo, Yumin;  Han, Run;  Ren, Zhengyu;  Ai, Nana;  Yu, Shaowen; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0 | Submit date：2024/11/05
Developmental Toxicity  Flavor  Geraniol  Nutrient Utilization  Zebrafish  
Protective effects of Amauroderma rugosum on dextran sulfate sodium-induced ulcerative colitis through the regulation of macrophage polarization and suppression of oxidative stress Journal article
Li, Jingjing, Luo, Xi, Shiu, Polly Ho Ting, Cheng, Yanfen, Nie, Xin, Rangsinth, Panthakarn, Lau, Benson Wui Man, Zheng, Chengwen, Li, Xuebo, Li, Renkai, Lee, Simon Ming Yuen, Fu, Chaomei, Seto, Sai Wang, Zhang, Jinming, Leung, George Pak Heng. Protective effects of Amauroderma rugosum on dextran sulfate sodium-induced ulcerative colitis through the regulation of macrophage polarization and suppression of oxidative stress[J]. Biomedicine and Pharmacotherapy, 2024, 176, 116901.
Authors:  Li, Jingjing;  Luo, Xi;  Shiu, Polly Ho Ting;  Cheng, Yanfen;  Nie, Xin; et al.
Favorite | TC[WOS]:0 TC[Scopus]:1  IF:6.9/6.8 | Submit date：2024/07/04
Amauroderma Rugosum  Macrophage Polarization  Oxidative Stress  Ulcerative Colitis  
Characterization of a polysaccharide from Amauroderma rugosum and its proangiogenic activities in vitro and in vivo Journal article
Nie, Xin, Li, Jingjing, Cheng, Yanfen, Rangsinth, Panthakarn, Wu, Xiaoping, Zheng, Chengwen, Shiu, Polly Ho Ting, Li, Renkai, Xu, Nan, He, Yulin, Lau, Benson Wui Man, Seto, Sai Wang, Zhang, Jinming, Lee, Simon Ming Yuen, Leung, George Pak Heng. Characterization of a polysaccharide from Amauroderma rugosum and its proangiogenic activities in vitro and in vivo[J]. International Journal of Biological Macromolecules, 2024, 271, 132533.
Authors:  Nie, Xin;  Li, Jingjing;  Cheng, Yanfen;  Rangsinth, Panthakarn;  Wu, Xiaoping; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:7.7/7.7 | Submit date：2024/06/05
Amauroderma Rugosum  Polysaccharides  Proangiogenesis  
A new invertebrate NPY-like polypeptide, ZoaNPY, from the Zoanthus sociatus, as a novel ligand of human NPY Y2 receptor rescues vascular insufficiency via PLC/PKC and Src- FAK-dependent signaling pathways Journal article
Chen, Qian, Xu, Nan, Zhao, Chen, He, Yulin, Kam, Sandy Hio Tong, Wu, Xue, Huang, Pan, Yang, Min, Wong, Clarence Tsun Ting, Radis-Baptista, Gandhi, Tang, Benqin, Fan, Guangyi, Gong, Guiyi, Lee, Simon Ming Yuen. A new invertebrate NPY-like polypeptide, ZoaNPY, from the Zoanthus sociatus, as a novel ligand of human NPY Y2 receptor rescues vascular insufficiency via PLC/PKC and Src- FAK-dependent signaling pathways[J]. Pharmacological Research, 2024, 203, 107173.
Authors:  Chen, Qian;  Xu, Nan;  Zhao, Chen;  He, Yulin;  Kam, Sandy Hio Tong; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:9.1/9.0 | Submit date：2024/05/16
Angiogenesis  Cnidarian  Invertebrate Neuropeptide y  Npy Y2r  Transcriptome  
Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation Journal article
Guo, Baojian, Zheng, Chengyou, Cao, Jie, Qiu, Xiaoling, Luo, Fangcheng, Li, Haitao, Lee, Simon Mingyuan, Yang, Xifei, Zhang, Gaoxiao, Sun, Yewei, Zhang, Zaijun, Wang, Yuqiang. Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation[J]. NeuroMolecular Medicine, 2024, 26(1), 9.
Authors:  Guo, Baojian;  Zheng, Chengyou;  Cao, Jie;  Qiu, Xiaoling;  Luo, Fangcheng; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:3.3/3.6 | Submit date：2024/05/16
Nuclear Factor Erythroid-2-related Factor 2  Parkinson’s Disease  Peroxisome Proliferator-activated Receptor γ Co-activator 1α  Tetramethylpyrazine Nitrone  Ubiquitin–proteasome System  Α-synuclein