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Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics Journal article
Lyu,Junfang, Yang,Eun Ju, Zhang,Baoyuan, Wu,Changjie, Pardeshi,Lakhansing, Shi,Changxiang, Mou,Pui Kei, Liu,Yifan, Tan,Kaeling, Shim,Joong Sup. Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics[J]. Nature Communications, 2020, 11(1), 5105.
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Zhang,Baoyuan;  Wu,Changjie;  Pardeshi,Lakhansing; et al.
Favorite | TC[WOS]:37 TC[Scopus]:36  IF:14.7/16.1 | Submit date：2021/03/04
Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Zhang,Baoyuan, Lyu,Junfang, Yang,Eun Ju, Liu,Yifan, Wu,Changjie, Pardeshi,Lakhansing, Tan,Kaeling, Chen,Qiang, Xu,Xiaoling, Deng,Chu Xia, Shim,Joong Sup. Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells[J]. Acta Pharmaceutica Sinica B, 2020, 10(4), 615-627.
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie; et al.
Favorite | TC[WOS]:23 TC[Scopus]:28  IF:14.7/14.1 | Submit date：2020/09/16
Brca1  Histone Deacetylase  Hdac  Synthetic Lethality  Reactive Oxygen Species  Dna Damage  Breast Cancer  
Histone acetyltransferase (HAT) P300/CBP inhibitors induce synthetic lethality in pten-deficient colorectal cancer cells through destabilizing AKT Journal article
Liu,Yifan, Yang,Eun Ju, Shi,Changxiang, Mou,Pui Kei, Zhang,Baoyuan, Wu,Changjie, Lyu,Junfang, Shim,Joong Sup. Histone acetyltransferase (HAT) P300/CBP inhibitors induce synthetic lethality in pten-deficient colorectal cancer cells through destabilizing AKT[J]. International Journal of Biological Sciences, 2020, 16(11), 1774-1784.
Authors:  Liu,Yifan;  Yang,Eun Ju;  Shi,Changxiang;  Mou,Pui Kei;  Zhang,Baoyuan; et al.
Favorite | TC[WOS]:15 TC[Scopus]:15  IF:8.2/8.3 | Submit date：2021/03/04
Akt  Anacardic Acid  Histone Acetyltransferases  Hsp70  Pten  Synthetic Lethality  
Cholesterol trafficking: An emerging therapeutic target for angiogenesis and cancer Review article
2019
Authors:  Junfang Lyu;  Eun Ju Yang;  Joong Sup Shim
Favorite | TC[WOS]:41 TC[Scopus]:47  IF:5.1/6.0 | Submit date：2022/05/17
Angiogenesis  Cholesterol Traffcking  Lysosome  Mtor  Npc1  
Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells Journal article
Wu, Changjie, Lyu, Junfang, Yang, Eun Ju, Liu, Yifan, Zhang, Baoyuan, Shim, Joong Sup. Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells[J]. NATURE COMMUNICATIONS, 2018, 9.
Authors:  Wu, Changjie;  Lyu, Junfang;  Yang, Eun Ju;  Liu, Yifan;  Zhang, Baoyuan; et al.
Favorite | TC[WOS]:95 TC[Scopus]:98  IF:14.7/16.1 | Submit date：2018/10/30
BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition Journal article
Baoyuan Zhang, Junfang Lyu, Yifan Liu, Changjie Wu, Eun Ju Yang, Lakhansing Pardeshi, Kaeling Tan, Koon Ho Wong, Qiang Chen, Xiaoling Xu, Chu-Xia Deng, Joong Sup Shim. BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition[J]. Oncogene, 2018(37), 6341–6356.
Authors:  Baoyuan Zhang;  Junfang Lyu;  Yifan Liu;  Changjie Wu;  Eun Ju Yang; et al.
Favorite | TC[WOS]:15 TC[Scopus]:12  IF:6.9/7.5 | Submit date：2018/12/17
Astemizole inhibits mTOR signaling and angiogenesis by blocking cholesterol trafficking Journal article
Lyu,Junfang, Yang,Eun Ju, Head,Sarah A., Ai,Nana, Zhang,Baoyuan, Wu,Changjie, Li,Ruo Jing, Liu,Yifan, Chakravarty,Harapriya, Zhang,Shaolin, Tam,Kin Yip, Dang,Yongjun, Kwon,Ho Jeong, Ge,Wei, Liu,Jun O., Shim,Joong Sup. Astemizole inhibits mTOR signaling and angiogenesis by blocking cholesterol trafficking[J]. International Journal of Biological Sciences, 2018, 14(10), 1175-1185.
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Head,Sarah A.;  Ai,Nana;  Zhang,Baoyuan; et al.
Favorite | TC[WOS]:21 TC[Scopus]:22  IF:8.2/8.3 | Submit date：2021/03/02
Angiogenesis  Astemizole  Cholesterol Trafficking  Mtor  Npc1  
Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking Journal article
Lyu, Junfang, Yang, Eun Ju, Head, Sarah A., Ai, Nana, Zhang, Baoyuan, Wu, Changjie, Li, Ruo-Jing, Liu, Yifan, Chakravarty, Harapriya, Zhang, Shaolin, Tam, Kin Yip, Dang, Yongjun, Kwon, Ho Jeong, Gel, Wei, Liu, Jun O., Shim, Joong Sup. Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018, 14(10), 1175-1185.
Authors:  Lyu, Junfang;  Yang, Eun Ju;  Head, Sarah A.;  Ai, Nana;  Zhang, Baoyuan; et al.
Favorite | TC[WOS]:21 TC[Scopus]:22  IF:8.2/8.3 | Submit date：2018/10/30
Cholesterol Trafficking  Angiogenesis  Astemizole  Npc1  Mtor  
PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A Journal article
Yifan Liu, Eun Ju Yang, Baoyuan Zhang, Zhengqiang Miao, Changjie Wu, Junfang Lyu, Kaeling Tan, Terence Chuen Wai Poon, Joong Sup Shim. PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A[J]. CANCER LETTERS, 2018, 436, 28-37.
Authors:  Yifan Liu;  Eun Ju Yang;  Baoyuan Zhang;  Zhengqiang Miao;  Changjie Wu; et al.
Favorite | TC[WOS]:13 TC[Scopus]:11  IF:9.1/8.3 | Submit date：2018/10/30
Akt  Kw2449  Synthetic Lethality  Aurka  Drug Combination  
Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth Journal article
Lyu, Junfang, Yang, Eun Ju, Head, Sarah A., Ai, Nana, Zhang, Baoyuan, Wu, Changjie, Li, Ruo-Jing, Liu, Yifan, Yang, Chen, Dang, Yongjun, Kwon, Ho Jeong, Ge, Wei, Liu, Jun O., Shim, Joong Sup. Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth[J]. CANCER LETTERS, 2017, 409, 91-103.
Authors:  Lyu, Junfang;  Yang, Eun Ju;  Head, Sarah A.;  Ai, Nana;  Zhang, Baoyuan; et al.
Favorite | TC[WOS]:56 TC[Scopus]:59  IF:9.1/8.3 | Submit date：2018/10/30
Cholesterol Trafficking  Angiogenesis  Tumor  Lysosome  Cepharanthine