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A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer Journal article
Xinhua Zhou, Anqi Wang, Liang Wang, Jianhua Yin, Li Wang, Lijun Di, Maggie Pui-Man Hoi, Luchen Shan, Xu Wu, Yuqiang Wang. A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer[J]. FRONTIERS IN PHARMACOLOGY, 2019, 10.
Authors:  Xinhua Zhou;  Anqi Wang;  Liang Wang;  Jianhua Yin;  Li Wang; et al.
Favorite | TC[WOS]:19 TC[Scopus]:20  IF:4.4/5.0 | Submit date：2020/05/21
Danshensu  Tetramethylpyrazine  Breast Cancer  Resistance  Glycolysis  P-glycoprotein  
A novel agent attenuates cardiotoxicity and improves antitumor activity of doxorubicin in breast cancer cells Journal article
Ying Zhang, Hongkuan Deng, Hefeng Zhou, Yucong Lu, Luchen Shan, Simon Ming‐Yuen Lee, Guozhen Cui. A novel agent attenuates cardiotoxicity and improves antitumor activity of doxorubicin in breast cancer cells[J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120(4), 5913-5922.
Authors:  Ying Zhang;  Hongkuan Deng;  Hefeng Zhou;  Yucong Lu;  Luchen Shan; et al.
Favorite | TC[WOS]:12 TC[Scopus]:12  IF:3.0/3.1 | Submit date：2020/01/16
Antitumor  Biotin-conjugated Adtm Analog (Baa)  Cardioprotection  Cardiotoxicity  Doxorubicin (Dox)  
A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor Journal article
Hu, Shengquan, Hu, Huihui, Mak, Shinghung, Cui, Guozhen, Lee, Mingyuen, Shan, Luchen, Wang, Yuqiang, Lin, Huangquan, Zhang, Zaijun, Han, Yifan. A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor[J]. FRONTIERS IN PHARMACOLOGY, 2018, 9.
Authors:  Hu, Shengquan;  Hu, Huihui;  Mak, Shinghung;  Cui, Guozhen;  Lee, Mingyuen; et al.
Favorite | TC[WOS]:17 TC[Scopus]:19  IF:4.4/5.0 | Submit date：2018/10/30
Alzheimer's Disease  Tetramethylpyrazine Derivative  Nmda Receptor  Neuroprotection  Oxidative Stress  Gsk3 Beta  
A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways Journal article
Tang, Fan, Zhou, Xinhua, Wang, Liang, Shan, Luchen, Li, Chuwen, Zhou, Hefeng, Lee, Simon Ming-Yuen, Hoi, Maggie Pui-Man. A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 820, 86-96.
Authors:  Tang, Fan;  Zhou, Xinhua;  Wang, Liang;  Shan, Luchen;  Li, Chuwen; et al.
Favorite | TC[WOS]:34 TC[Scopus]:33  IF:4.2/4.3 | Submit date：2018/10/30
Cardioprotection  Anti-oxidative Stress  Anti-apoptosis  Autophagy Regulation  Zebrafish Cardiotoxicity  H9c2 Cardiomyocytes  
A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in Vitro and in Vivo Journal article
Guozhen Cui, Luchen Shan, Yang Chen, Hefeng Zhou, Yuqiang Wang, Simon Ming-Yuen Lee. A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in Vitro and in Vivo[J]. American Journal of Chinese Medicine, 2016, 44(7), 1349-1361.
Authors:  Guozhen Cui;  Luchen Shan;  Yang Chen;  Hefeng Zhou;  Yuqiang Wang; et al.
Favorite | TC[WOS]:11 TC[Scopus]:11 | Submit date：2018/11/06
Anti-inflammation  Anti-oxidation  Danshensu Derivative  Neuroprotection  
A novel agent enhances the chemotherapeutic efficacy of doxorubicin in MCF-7 breast cancer cells Journal article
Liang Wang, Judy Y. Chan, Xinhua Zhou, Guozhen Cui, Zhixiang Yan, Li Wang, Ru Yan, Lijun Di, Yuqiang Wang, Maggie P. Hoi, Luchen Shan, Simon M. Lee. A novel agent enhances the chemotherapeutic efficacy of doxorubicin in MCF-7 breast cancer cells[J]. Frontiers in Pharmacology, 2016, 7(AUG).
Authors:  Liang Wang;  Judy Y. Chan;  Xinhua Zhou;  Guozhen Cui;  Zhixiang Yan; et al.
Favorite | TC[WOS]:16 TC[Scopus]:19  IF:4.4/5.0 | Submit date：2018/11/06
Breast Cancer  Danshensu  Doxorubicin  Glycolysis  Grp78 Protein  Tetramethylpyrazine  
A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II Journal article
Liang Wang, Xiaojing Zhang, Guozhen Cui, Judy Yuet-Wa Chan, Li Wang, Chuwen Li, Luchen Shan, Changjiang Xu, Qingwen Zhang, Yuqiang Wang, Lijun Di, Simon Ming-Yuen Lee. A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II[J]. Oncotarget, 2016, 7(22), 32054-32064.
Authors:  Liang Wang;  Xiaojing Zhang;  Guozhen Cui;  Judy Yuet-Wa Chan;  Li Wang; et al.
Favorite | TC[WOS]:34 TC[Scopus]:39  IF:5.168/5.312 | Submit date：2018/11/06
Breast Cancer  Danshensu  Mitochondrial Complex Ii  Reactive Oxygen Species  Tetramethylpyrazine  
Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries Journal article
Rachel Wai-Sum Li, C. Yang, Luchen Shan, Zaijun Zhang, Yuqiang Wang, Y.W. Kwan, Simon M.Y. Lee, Maggie P.M. Hoi, S.W. Chan, Alex Chun Cheung, K.H. Cheung, George P.H. Leung. Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries[J]. European Journal of Pharmacology, 2015, 761, 153-160.
Authors:  Rachel Wai-Sum Li;  C. Yang;  Luchen Shan;  Zaijun Zhang;  Yuqiang Wang; et al.
Favorite | TC[WOS]:17 TC[Scopus]:16  IF:4.2/4.3 | Submit date：2018/11/06
Calcium Channel  Danshensu Tetramethylpyrazine  Mesenteric Artery  Relaxation  
Identification of disulfide isomerase ERp57 as a target for small molecule cardioprotective agents Journal article
Guozhen Cui, Luchen Shan, Ivan Keung Chu, Guohui Li, George Pak Heng Leung, Yuqiang Wang, Yiu Wa KWAN, Shun Wan CHAN, Maggie Pui Man Hoi, Simon Ming Yuen Lee. Identification of disulfide isomerase ERp57 as a target for small molecule cardioprotective agents[J]. RSC Advances, 2015, 5(91), 74605-74610.
Authors:  Guozhen Cui;  Luchen Shan;  Ivan Keung Chu;  Guohui Li;  George Pak Heng Leung; et al.
Favorite | TC[WOS]:11 TC[Scopus]:14  IF:3.9/3.9 | Submit date：2018/11/06
A Novel Danshensu Derivative Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer Cells Journal article
Liang Wang, Xiaojing Zhang, Judy Yuet‐Wa Chan, Luchen Shan, Guozhen Cui, Qingbin Cui, Yingfei Wang, Jingjing Li, Huanxian Chen, Qingwen Zhang, Pei Yu, Yifan Han, Yuqiang Wang, Simon Ming‐Yuen Lee. A Novel Danshensu Derivative Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer Cells[J]. Journal of Cellular Biochemistry, 2015, 117(1), 94-105.
Authors:  Liang Wang;  Xiaojing Zhang;  Judy Yuet‐Wa Chan;  Luchen Shan;  Guozhen Cui; et al.
Favorite | TC[WOS]:29 TC[Scopus]:32  IF:3.0/3.1 | Submit date：2018/11/06
Breast Cancer  Cardiotoxicity  Doxorubicin  Mitochondrial Biogenesis