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Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson's disease models Journal article
Guo, Baojian, Zheng, Chengyou, Cao, Jie, Luo, Fangcheng, Li, Haitao, Hu, Shengquan, Mingyuan Lee, Simon, Yang, Xifei, Zhang, Gaoxiao, Zhang, Zaijun, Sun, Yewei, Wang, Yuqiang. Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson's disease models[J]. Journal of Advanced Research, 2024, 64, 195-211.
Authors:  Guo, Baojian;  Zheng, Chengyou;  Cao, Jie;  Luo, Fangcheng;  Li, Haitao; et al.
Favorite | TC[WOS]:4 TC[Scopus]:4  IF:11.4/11.0 | Submit date：2024/02/22
Nuclear Factor Erythroid-2-related Factor 2  Parkinson's Disease  Peroxisome Proliferator-activated Receptor γ Co-activator 1α  Tetramethylpyrazine Nitrone  
A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor Journal article
Hu, Shengquan, Hu, Huihui, Mak, Shinghung, Cui, Guozhen, Lee, Mingyuen, Shan, Luchen, Wang, Yuqiang, Lin, Huangquan, Zhang, Zaijun, Han, Yifan. A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor[J]. FRONTIERS IN PHARMACOLOGY, 2018, 9.
Authors:  Hu, Shengquan;  Hu, Huihui;  Mak, Shinghung;  Cui, Guozhen;  Lee, Mingyuen; et al.
Favorite | TC[WOS]:17 TC[Scopus]:19  IF:4.4/5.0 | Submit date：2018/10/30
Alzheimer's Disease  Tetramethylpyrazine Derivative  Nmda Receptor  Neuroprotection  Oxidative Stress  Gsk3 Beta  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
Guo, Baojian, Hu, Shengquan, Zheng, Chengyou, Wang, Hongyu, Luo, Fangcheng, Li, Haitao, Cui, Wei, Yang, Xifei, Cui, Guozhen, Mak, Shinghung, Choi, Tony Chung-Lit, Ma, Edmond Dik-Lung, Wang, Yuqiang, Lee, Simon Ming Yuen, Zhang, Zaijun, Han, Yifan. Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B[J]. NEUROPHARMACOLOGY, 2017, 126, 12-24.
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng; et al.
View | Adobe PDF | Favorite | TC[WOS]:18 TC[Scopus]:20  IF:4.6/4.5 | Submit date：2018/10/31
Parkinson's Disease  Su4312  Neuroprotection  Myocyte Enhancer Factor 2d  Monoamine Oxidase-b  
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3 beta and the ERK Pathway Journal article
Yu, Jie, Zheng, Jiacheng, Lin, Jiajia, Jin, Linlu, Yu, Rui, Mak, Shinghung, Hu, Shengquan, Sun, Hongya, Wu, Xiang, Zhang, Zaijun, Lee, Mingyuen, Tsim, Wahkeung, Su, Wei, Zhou, Wenhua, Cui, Wei, Han, Yifan, Wang, Qinwen. Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3 beta and the ERK Pathway[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY, 2017, 37(4), 655-664.
Authors:  Yu, Jie;  Zheng, Jiacheng;  Lin, Jiajia;  Jin, Linlu;  Yu, Rui; et al.
Favorite | TC[WOS]:20 TC[Scopus]:23  IF:3.6/4.2 | Submit date：2018/10/30
Indirubin-3-oxime  H2o2  Gsk3 Beta  Pi3-k  Erk  
Potent Protection Against MPP+-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine Journal article
Hu, Shengquan, Wang, Liang, Mak, Shinghung, Zhang, Zaijun, Xu, Daping, Li, Haitao, Li, Yide, Hu, Yuanjia, Lee, Simon Ming Yuen, Wang, Yuqiang, Han, Yifan. Potent Protection Against MPP+-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine[J]. NEUROMOLECULAR MEDICINE, 2016.
Authors:  Hu, Shengquan;  Wang, Liang;  Mak, Shinghung;  Zhang, Zaijun;  Xu, Daping; et al.
Favorite | TC[WOS]:9 TC[Scopus]:9  IF:3.3/3.6 | Submit date：2022/08/31
Potent Protection Against MPP+ -Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine Journal article
Shengquan Hu, Liang Wang, Shinghung Mak, Zaijun Zhang, Daping Xu, Haitao Li, Yide Li, Yuanjia Hu, Simon Ming Yuen Lee, Yuqiang Wang, Yifan Han. Potent Protection Against MPP+ -Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine[J]. NEUROMOLECULAR MEDICINE, 2016, 18(4), 561-572.
Authors:  Shengquan Hu;  Liang Wang;  Shinghung Mak;  Zaijun Zhang;  Daping Xu; et al.
Favorite | TC[WOS]:9 TC[Scopus]:9  IF:3.3/3.6 | Submit date：2020/01/16
Parkinson’s Disease  Mef2d  Neuroprotection  
Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer Journal article
Shengquan Hu, Wei Cui, Shinghung Mak, Daping Xu, Yuanjia Hu, Jing Tang, Chunglit Choi, Mingyuen Lee, Yuanping Pang, Yifan Han. Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer[J]. ACS Chemical Neuroscience, 2015, 6(9), 1536-1545.
Authors:  Shengquan Hu;  Wei Cui;  Shinghung Mak;  Daping Xu;  Yuanjia Hu; et al.
Favorite | TC[WOS]:21 TC[Scopus]:21  IF:4.1/4.3 | Submit date：2018/11/06
Alpha7-nicotinic Acetylcholine Receptor  Alzheimer's Disease  Bis(Propyl)-cognitin  Extracellular Signal-regulated Kinase  Neurite Outgrowth  Neuroprotection  
Inhibiting β-Amyloid-Associated Alzheimer’s Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue Journal article
Shengquan Hu, Rui Wang, Wei Cui, Zaijun Zhang, Shinghung Mak, Daping Xu, Chunglit Choi, Karl Wahkeung Tsim, Paul R. Carlier, Mingyuen Lee, Yifan Han. Inhibiting β-Amyloid-Associated Alzheimer’s Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue[J]. Journal of Molecular Neuroscience, 2015, 55(4), 1014.
Authors:  Shengquan Hu;  Rui Wang;  Wei Cui;  Zaijun Zhang;  Shinghung Mak; et al.
Favorite | TC[WOS]:15 TC[Scopus]:15 | Submit date：2018/10/30
Alzheimer’s Disease  Aβ Fibrils  Bis(12)-hupyridone  Cell Viability  Memory Impairment  Thioflavin t  
Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β Journal article
Shengquan Hu, Wei Cui, Zaijun Zhang, Shinghung Mak, Daping Xu, Gang Li, Yuanjia Hu, Yuqiang Wang, Mingyuen Lee, Karl Wahkeung Tsim, Yifan Han. Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β[J]. Journal of Molecular Neuroscience, 2015, 57(4), 561–570.
Authors:  Shengquan Hu;  Wei Cui;  Zaijun Zhang;  Shinghung Mak;  Daping Xu; et al.
Favorite | TC[WOS]:27 TC[Scopus]:30  IF:2.8/2.8 | Submit date：2018/10/30
6ohda  Gsk3β  Indirubin-3-oxime  Mef2d  Neuroprotection  Parkinson’s Disease  
The anti-cancer agent SU4312 unexpectedly protects against MPP+- induced neurotoxicity via selective and direct inhibition of neuronal NOS Journal article
Wei Cui, Zaijun Zhang, Wenming Li, Shengquan Hu, Shinghung Mak, Huan Zhang, Renwen Han, Shuai Yuan, Sai Li, Fei Sa, Daping Xu, Zhixiu Lin, Zhong Zuo, Jianhui Rong, Edmond Dik-Lung Ma, Tony Chunglit Choi, Simon MY Lee, Yifan Han. The anti-cancer agent SU4312 unexpectedly protects against MPP+- induced neurotoxicity via selective and direct inhibition of neuronal NOS[J]. British Journal of Pharmacology, 2013, 168(5), 1201.
Authors:  Wei Cui;  Zaijun Zhang;  Wenming Li;  Shengquan Hu;  Shinghung Mak; et al.
Favorite | TC[WOS]:59 TC[Scopus]:59 | Submit date：2018/10/30
Angiogenesis  Su4312  Neuroprotection  Parkinson’s Disease  Neuronal Nos  Mpp++++