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BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance Journal article
Xiaodong Shu, Jianjie Li, Un In Chan, Sek Man Su, Changxiang Shi, Xin Zhang, Tingting An, Jun Xu, Lihua Mo, Jianlin Liu, Yuqing Wang, Xiaoling Li, Min Deng, Josh Haipeng Lei, Chunfei Wang, Hao Tian, Sun Heng, Joong Sup Shim, Xuanjun Zhang, Yunlu Dai, Zhicheng Yao, Xiaying Kuang, Ying Lin, Chu-Xia Deng, Xiaoling Xu. BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance[J]. CANCER RESEARCH, 2023, 83(15), 2614-2633.
Authors:  Xiaodong Shu;  Jianjie Li;  Un In Chan;  Sek Man Su;  Changxiang Shi; et al.
Favorite | TC[WOS]:2 TC[Scopus]:3  IF:12.5/11.6 | Submit date：2023/08/30
S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy Journal article
Jianjie Li, Xiaodong Shu, Jun Xu, Sek Man Su, Un In Chan, Lihua Mo, Jianlin Liu, Xin Zhang, Ragini Adhav, Qiang Chen, Yuqing Wang, Tingting An, Xu Zhang, Xueying Lyu, Xiaoling Li, Josh Haipeng Lei, Kai Miao, Heng Sun, Fuqiang Xing, Aiping Zhang, Chuxia Deng, Xiaoling Xu. S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy[J]. Nature Communications, 2022, 13(1), 1481.
Authors:  Jianjie Li;  Xiaodong Shu;  Jun Xu;  Sek Man Su;  Un In Chan; et al.
Favorite | TC[WOS]:37 TC[Scopus]:43  IF:14.7/16.1 | Submit date：2022/05/13
ATP11B inhibits breast cancer metastasis in a mouse model by suppressing externalization of nonapoptotic phosphatidylserine Journal article
Xu, Jun, Su, Sek Man, Zhang, Xin, Chan, Un In, Adhav, Ragini, Shu, Xiaodong, Liu, Jianlin, Li, Jianjie, Mo, Lihua, Wang, Yuqing, An, Tingting, Lei, Josh Haipeng, Miao, Kai, Deng, Chu Xia, Xu, Xiaoling. ATP11B inhibits breast cancer metastasis in a mouse model by suppressing externalization of nonapoptotic phosphatidylserine[J]. JOURNAL OF CLINICAL INVESTIGATION, 2022, 132(5), e149473.
Authors:  Xu, Jun;  Su, Sek Man;  Zhang, Xin;  Chan, Un In;  Adhav, Ragini; et al.
Favorite | TC[WOS]:10 TC[Scopus]:11  IF:13.3/14.6 | Submit date：2022/03/28
Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice Journal article
Qiu, Pengxiang, Hou, Weilong, Wang, Haitao, Lei, Kimmy Ka Wing, Wang, Shaowei, Chen, Weiping, Pardeshi, Lakhansing Arun, Prothro, Katherine, Shukla, Yashvita, Su, Samson Sek Man, Schrump, David S., Chen, Qiang, Deng, Chu Xia, Xu, Xiaoling, Wang, Ruihong. Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice[J]. Oncogene, 2021, 40(41), 6023-6033.
Authors:  Qiu, Pengxiang;  Hou, Weilong;  Wang, Haitao;  Lei, Kimmy Ka Wing;  Wang, Shaowei; et al.
Favorite | TC[WOS]:10 TC[Scopus]:9  IF:6.9/7.5 | Submit date：2021/12/08
Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform Journal article
Xing, Fuqiang, Liu, Yu Cheng, Huang, Shigao, Lyu, Xueying, Su, Sek Man, Chan, Un In, Wu, Pei Chun, Yan, Yinghan, Ai, Nana, Li, Jianjie, Zhao, Ming, Rajendran, Barani Kumar, Liu, Jianlin, Shao, Fangyuan, Sun, Heng, Choi, Tak Kan, Zhu, Wenli, Luo, Guanghui, Liu, Shuiming, Xu, De Li, Chan, Kin Long, Zhao, Qi, Miao, Kai, Luo, Kathy Qian, Ge, Wei, Xu, Xiaoling, Wang, Guanyu, Liu, Tzu Ming, Deng, Chu Xia. Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform[J]. Theranostics, 2021, 11(19), 9415-9430.
Authors:  Xing, Fuqiang;  Liu, Yu Cheng;  Huang, Shigao;  Lyu, Xueying;  Su, Sek Man; et al.
Adobe PDF | Favorite | TC[WOS]:16 TC[Scopus]:18  IF:12.4/12.0 | Submit date：2021/11/30
3d Tumor Slice Culture  Apoptosis  Fret Technique  Label-free  Personalized Medicine  
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics Journal article
Ding, Ren Bo, Chen, Ping, Rajendran, Barani Kumar, Lyu, Xueying, Wang, Haitao, Bao, Jiaolin, Zeng, Jianming, Hao, Wenhui, Sun, Heng, Wong, Ada Hang Heng, Valecha, Monica Vishnu, Yang, Eun Ju, Su, Sek Man, Choi, Tak Kan, Liu, Shuiming, Chan, Kin Iong, Yang, Ling Lin, Wu, Jingbo, Miao, Kai, Chen, Qiang, Shim, Joong Sup, Xu, Xiaoling, Deng, Chu Xia. Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics[J]. Nature Communications, 2021, 12(1), 3046.
Authors:  Ding, Ren Bo;  Chen, Ping;  Rajendran, Barani Kumar;  Lyu, Xueying;  Wang, Haitao; et al.
Favorite | TC[WOS]:53 TC[Scopus]:53  IF:14.7/16.1 | Submit date：2021/11/30
Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing Journal article
Sun, Heng, Zeng, Jianming, Miao, Zhengqiang, Lei, Kuan Cheok, Huang, Chen, Hu, Lingling, Su, Sek Man, Chan, Un In, Miao, Kai, Zhang, Xu, Zhang, Aiping, Guo, Sen, Chen, Si, Meng, Ya, Deng, Min, Hao, Wenhui, Lei, Haipeng, Lin, Ying, Yang, Zhonglin, Tang, Dongjiang, Wong, Koon Ho, Zhang, Xiaohua Douglas, Xu, Xiaoling, Deng, Chu Xia. Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing[J]. Theranostics, 2021, 11(20), 9967 - 9987.
Authors:  Sun, Heng;  Zeng, Jianming;  Miao, Zhengqiang;  Lei, Kuan Cheok;  Huang, Chen; et al.
Favorite | TC[WOS]:4 TC[Scopus]:5  IF:12.4/12.0 | Submit date：2021/11/30
Brca1/brca1  Mammary Tumor  Mrc2  Single Cell Rna-seq  Tumor Heterogeneity  
Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor Journal article
Liu,Jianlin, Adhav,Ragini, Miao,Kai, Su,Sek Man, Mo,Lihua, Chan,Un In, Zhang,Xin, Xu,Jun, Li,Jianjie, Shu,Xiaodong, Zeng,Jianming, Zhang,Xu, Lyu,Xueying, Pardeshi,Lakhansing, Tan,Kaeling, Sun,Heng, Wong,Koon Ho, Deng,Chuxia, Xu,Xiaoling. Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor[J]. Nature Communications, 2020, 11(1).
Authors:  Liu,Jianlin;  Adhav,Ragini;  Miao,Kai;  Su,Sek Man;  Mo,Lihua; et al.
Favorite | TC[WOS]:23 TC[Scopus]:25  IF:14.7/16.1 | Submit date：2021/03/02
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation Journal article
Miao,Kai, Lei,Josh Haipeng, Valecha,Monica Vishnu, Zhang,Aiping, Xu,Jun, Wang,Lijian, Lyu,Xueying, Chen,Si, Miao,Zhengqiang, Zhang,Xin, Su,Sek Man, Shao,Fangyuan, Rajendran,Barani Kumar, Bao,Jiaolin, Zeng,Jianming, Sun,Heng, Chen,Ping, Tan,Kaeling, Chen,Qiang, Wong,Koon Ho, Xu,Xiaoling, Deng,Chu Xia. NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation[J]. Nature Communications, 2020, 11(1), 3256.
Authors:  Miao,Kai;  Lei,Josh Haipeng;  Valecha,Monica Vishnu;  Zhang,Aiping;  Xu,Jun; et al.
Favorite | TC[WOS]:59 TC[Scopus]:68  IF:14.7/16.1 | Submit date：2020/09/16
Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-G374R mutation in achondroplasia in mice Journal article
Miao,Kai, Zhang,Xin, Su,Sek Man, Zeng,Jianming, Huang,Zebin, Chan,Un In, Xu,Xiaoling, Deng,Chu Xia. Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-G374R mutation in achondroplasia in mice[J]. Journal of Biological Chemistry, 2019, 294(4), 1142-1151.
Authors:  Miao,Kai;  Zhang,Xin;  Su,Sek Man;  Zeng,Jianming;  Huang,Zebin; et al.
Favorite | TC[WOS]:10 TC[Scopus]:11  IF:4.0/4.4 | Submit date：2020/09/16