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ChemistGA: A Chemical Synthesizable Accessible Molecular Generation Algorithm for Real-World Drug Discovery Journal article
Wang, Jike, Wang, Xiaorui, Sun, Huiyong, Wang, Mingyang, Zeng, Yundian, Jiang, Dejun, Wu, Zhenxing, Liu, Zeyi, Liao, Ben, Yao, Xiaojun, Hsieh, Chang Yu, Cao, Dongsheng, Chen, Xi, Hou, Tingjun. ChemistGA: A Chemical Synthesizable Accessible Molecular Generation Algorithm for Real-World Drug Discovery[J]. Journal of Medicinal Chemistry, 2022, 65(18), 12482-12496.
Authors:  Wang, Jike;  Wang, Xiaorui;  Sun, Huiyong;  Wang, Mingyang;  Zeng, Yundian; et al.
Favorite | TC[WOS]:9 TC[Scopus]:13  IF:6.8/7.1 | Submit date：2023/01/30
RELATION: A Deep Generative Model for Structure-Based De Novo Drug Design Journal article
Wang, Mingyang, Hsieh, Chang Yu, Wang, Jike, Wang, Dong, Weng, Gaoqi, Shen, Chao, Yao, Xiaojun, Bing, Zhitong, Li, Honglin, Cao, Dongsheng, Hou, Tingjun. RELATION: A Deep Generative Model for Structure-Based De Novo Drug Design[J]. Journal of Medicinal Chemistry, 2022, 65(13), 9478-9492.
Authors:  Wang, Mingyang;  Hsieh, Chang Yu;  Wang, Jike;  Wang, Dong;  Weng, Gaoqi; et al.
Favorite | TC[WOS]:33 TC[Scopus]:41  IF:6.8/7.1 | Submit date：2023/01/30
Discovery of N-(4-(Benzyloxy)-phenyl)-sulfonamide Derivatives as Novel Antagonists of the Human Androgen Receptor Targeting the Activation Function 2 Journal article
Chai, Xin, Sun, Huiyong, Zhou, Wenfang, Chen, Changwei, Shan, Luhu, Yang, Yuhui, He, Junzhao, Pang, Jinping, Yang, Liu, Wang, Xinyue, Cui, Sunliang, Fu, Yaqin, Xu, Xiaohong, Xu, Lei, Yao, Xiaojun, Li, Dan, Hou, Tingjun. Discovery of N-(4-(Benzyloxy)-phenyl)-sulfonamide Derivatives as Novel Antagonists of the Human Androgen Receptor Targeting the Activation Function 2[J]. Journal of Medicinal Chemistry, 2022, 65(3), 2507-2521.
Authors:  Chai, Xin;  Sun, Huiyong;  Zhou, Wenfang;  Chen, Changwei;  Shan, Luhu; et al.
Favorite | TC[WOS]:12 TC[Scopus]:11  IF:6.8/7.1 | Submit date：2023/01/30
Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin Journal article
Shang Li, Nana Ai, Mingyun Shen, Yuanye Dang, Cheong-Meng Chong, Peichen Pan, Yiu Wa Kwan, Shun Wan Chan, George Pak Heng Leung, Maggie Pui Man Hoi, Tingjun Hou, Simon Ming-Yuen Lee. Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin[J]. Cell Death Discovery, 2017, 3.
Authors:  Shang Li;  Nana Ai;  Mingyun Shen;  Yuanye Dang;  Cheong-Meng Chong; et al.
Favorite | TC[WOS]:16 TC[Scopus]:16  IF:6.1/6.0 | Submit date：2020/01/16
Discovery of a novel ROCK2 inhibitor with anti-migration effects: Via docking and high-content drug screening Journal article
Cheong-Meng Chong, Man-Teng Kou, Peichen Pan, Hefeng Zhou, Nana Ai, Chuwen Li, Hai-Jing Zhong, Chung-Hang Leung, Tingjun Hou, Simon Ming-Yuen Lee. Discovery of a novel ROCK2 inhibitor with anti-migration effects: Via docking and high-content drug screening[J]. Molecular BioSystems, 2016, 12(9), 2713-2721.
Authors:  Cheong-Meng Chong;  Man-Teng Kou;  Peichen Pan;  Hefeng Zhou;  Nana Ai; et al.
Favorite | TC[WOS]:15 TC[Scopus]:14 | Submit date：2018/11/06
Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening Journal article
Cheong-Meng Chong, Man-Teng Kou, Peichen Pan, Hefeng Zhou, Nana Ai, Chuwen Li, Hai-Jing Zhong, Chung-Hang Leung, Tingjun Hou, Simon Ming-Yuen Lee. Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening[J]. MOLECULAR BIOSYSTEMS, 2016, 12(9), 2713-2721.
Authors:  Cheong-Meng Chong;  Man-Teng Kou;  Peichen Pan;  Hefeng Zhou;  Nana Ai; et al.
Favorite | TC[WOS]:15 TC[Scopus]:14  IF:3.336/2.986 | Submit date：2020/07/30
Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models Journal article
Cheong-Meng Chong, Dan Ma, Chao Zhao, Robin J.M. Franklin, Zhong-Yan Zhou, Nana Ai, Chuwen Li, Huidong Yu, Tingjun Hou, Tingjun Hou, Simon Ming-Yuen Lee. Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models[J]. Free Radical Biology and Medicine, 2015, 89, 1057-1066.
Authors:  Cheong-Meng Chong;  Dan Ma;  Chao Zhao;  Robin J.M. Franklin;  Zhong-Yan Zhou; et al.
Favorite | TC[WOS]:22 TC[Scopus]:22  IF:7.1/7.9 | Submit date：2018/11/06
Mpp++++  Neurodegeneration  Rat Organotypiccerebellarcultures  Zebrafish  
Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays Journal article
Mingyun Shen, Sheng Tian, Peichen Pan, Huiyong Sun, Dan Li, Youyong Li, Hefeng Zhou, Chuwen Li, Simon Ming-Yuen Lee, Tingjun Hou. Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays[J]. Scientific Reports, 2015, 5.
Authors:  Mingyun Shen;  Sheng Tian;  Peichen Pan;  Huiyong Sun;  Dan Li; et al.
Favorite | TC[WOS]:22 TC[Scopus]:27  IF:3.8/4.3 | Submit date：2018/11/06
Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP+-induced oxidative stress and cell death in SH-SY5Y cells Journal article
Cheong-Meng Chong, Mingyun Shen, Zhong-Yan Zhou, Peichen Pan, Pui-Man Hoi, Shang Li, Wang Liang, Nana Ai, Lun-Qing Zhang, Cheuk-Wing Li, Huidong Yu, Tingjun Hou, Simon Ming-Yuen Lee. Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP+-induced oxidative stress and cell death in SH-SY5Y cells[J]. FREE RADICAL BIOLOGY AND MEDICINE, 2014, 74, 283-293.
Authors:  Cheong-Meng Chong;  Mingyun Shen;  Zhong-Yan Zhou;  Peichen Pan;  Pui-Man Hoi; et al.
Favorite | TC[WOS]:32 TC[Scopus]:31  IF:7.1/7.9 | Submit date：2020/04/15
Parkinson Disease  Free Radicals  No  Ros  Rock  Benzofuran  
Discovery of Rho-kinase inhibitors by docking-based virtual screening Journal article
Mingyun Shen, Huidong Yu, Youyong Li, Pixu Li, Peichen Pan, Shunye Zhou, Liling Zhang, Shang Li, Simon Ming-Yuen Lee, Tingjun Hou. Discovery of Rho-kinase inhibitors by docking-based virtual screening[J]. Molecular BioSystems, 2013, 9(6), 1511-1521.
Authors:  Mingyun Shen;  Huidong Yu;  Youyong Li;  Pixu Li;  Peichen Pan; et al.
Favorite | TC[WOS]:47 TC[Scopus]:51  IF:3.336/2.986 | Submit date：2018/10/30