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Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy Journal article
Zhu, Zhou, Liu, Liang feng, Su, Cheng fu, Liu, Jia, Tong, Benjamin Chun Kit, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Sreenivasmurthy, Sravan Gopalkrishnashetty, Guan, Xin jie, Kan, Yu xuan, Xie, Wen jian, Zhao, Chen liang, Cheung, King ho, Lu, Jia hong, Tan, Jie qiong, Zhang, Hong jie, Song, Ju xian, Li, Min. Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy[J]. Acta Pharmacologica Sinica, 2022, 43(10), 2511-2526.
Authors:  Zhu, Zhou;  Liu, Liang feng;  Su, Cheng fu;  Liu, Jia;  Tong, Benjamin Chun Kit; et al.
Favorite | TC[WOS]:25 TC[Scopus]:21  IF:6.9/7.6 | Submit date：2022/05/17
Autophagy  Corynoxine b  Dopaminergic Neuron  
TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2 Journal article
Yang, Chuan bin, Liu, Jia, Tong, Benjamin Chun Kit, Wang, Zi ying, Zhu, Zhou, Su, Cheng fu, Sreenivasmurthy, Sravan Gopalkrishnashetty, Wu, Jia xi, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Huang, Shi ying, Cheung, King ho, Song, Ju xian, Tan, Jie qiong, Lu, Jia hong, Li, Min. TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2[J]. Acta Pharmacologica Sinica, 2022, 43(5), 1251-1263.
Authors:  Yang, Chuan bin;  Liu, Jia;  Tong, Benjamin Chun Kit;  Wang, Zi ying;  Zhu, Zhou; et al.
Favorite | TC[WOS]:18 TC[Scopus]:19  IF:6.9/7.6 | Submit date：2022/05/13
15-deoxy-∆-12,14-prostaglandin J2 (15d-pgJ2)  Apoptosis  Atf4  Autophagy And Lysosome Biogenesis  Er Stress  Transcriptional Factor Eb (tfEb)  
Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models Journal article
Iyaswamy, Ashok, Wang, Xueli, Krishnamoorthi, Senthilkumar, Kaliamoorthy, Venkatapathy, Sreenivasmurthy, Sravan G., Kumar Durairajan, Siva Sundara, Song, Ju Xian, Tong, Benjamin Chun kit, Zhu, Zhou, Su, Cheng Fu, Liu, Jia, Cheung, King Ho, Lu, Jia Hong, Tan, Jie Qiong, Li, Hung Wing, Wong, Man Shing, Li, Min. Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models[J]. Redox Biology, 2022, 51, 102280.
Authors:  Iyaswamy, Ashok;  Wang, Xueli;  Krishnamoorthi, Senthilkumar;  Kaliamoorthy, Venkatapathy;  Sreenivasmurthy, Sravan G.; et al.
Favorite | TC[WOS]:48 TC[Scopus]:51  IF:10.7/11.7 | Submit date：2022/05/13
Theranostic  Alzheimer’s Disease  Aβ-targeting  Aβ-aggregate Inhibition  3xtg-ad  5xfad  
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease Journal article
Tong, Benjamin Chun Kit, Wu, Aston Jiaxi, Huang, Alexis Shiying, Dong, Rui, Malampati, Sandeep, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Sreenivasmurthy, Sravan Gopalkrishnashetty, Zhu, Zhou, Su, Chengfu, Liu, Jia, Song, Juxian, Lu, Jia Hong, Tan, Jieqiong, Pan, Weidong, Li, Min, Cheung, King Ho. Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease[J]. Autophagy, 2021, 18(3), 624-642.
Authors:  Tong, Benjamin Chun Kit;  Wu, Aston Jiaxi;  Huang, Alexis Shiying;  Dong, Rui;  Malampati, Sandeep; et al.
Favorite | TC[WOS]:30 TC[Scopus]:30  IF:14.6/16.8 | Submit date：2022/05/17
Alzheimer Disease  Autophagy-lysosomal Pathway  Calcium Ion  Presenilin-1  Two Pore Segment Channel 2  
A curcumin derivative activates TFEB and protects against parkinsonian neurotoxicity in vitro Journal article
Wang,Ziying, Yang,Chuanbin, Liu,Jia, Tong,Benjamin Chun Kit, Zhu,Zhou, Malampati,Sandeep, Sreenivasmurthy,Sravan Gopalkrishnashetty, Cheung,King Ho, Iyaswamy,Ashok, Su,Chengfu, Lu,Jiahong, Song,Juxian, Li,Min. A curcumin derivative activates TFEB and protects against parkinsonian neurotoxicity in vitro[J]. International Journal of Molecular Sciences, 2020, 21(4), 1515.
Authors:  Wang,Ziying;  Yang,Chuanbin;  Liu,Jia;  Tong,Benjamin Chun Kit;  Zhu,Zhou; et al.
Favorite | TC[WOS]:33 TC[Scopus]:40  IF:4.9/5.6 | Submit date：2021/03/02
Curcumin Derivatives  Mtorc1  Parkinson’s Disease  Tfeb  Α-synuclein  
A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models Journal article
Ju-Xian Song, Sandeep Malampati, Yu Zeng, Siva Sundara Kumar Durairajan, Chuan-Bin Yang, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Wen-Bin Shang, Sreenivasmurthy,Sravan Gopalkrishnashetty, Zhou Zhu, King-Ho Cheung, Jia-Hong Lu, Chunzhi Tang, Nenggui Xu, Min Li. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models[J]. AGING CELL, 2020, 19(2).
Authors:  Ju-Xian Song;  Sandeep Malampati;  Yu Zeng;  Siva Sundara Kumar Durairajan;  Chuan-Bin Yang; et al.
Favorite | TC[WOS]:106 TC[Scopus]:114  IF:8.0/9.7 | Submit date：2021/03/02
Alzheimer's Disease  Beta-amyloid  Curcumin Analog C1  Mapt/tau  Tfeb  
Targeting Aggrephagy for the Treatment of Alzheimer's Disease Journal article
Malampati, Sandeep, Song, Ju Xian, Chun-Kit Tong, Benjamin, Nalluri, Anusha, Yang, Chuan Bin, Wang, Ziying, Gopalkrishnashetty Sreenivasmurthy, Sravan, Zhu, Zhou, Liu, Jia, Su, Chengfu, Krishnamoorthi, Senthilkumar, Iyaswamy, Ashok, Cheung, King Ho, Lu, Jia Hong, Li, Min. Targeting Aggrephagy for the Treatment of Alzheimer's Disease[J]. Cells, 2020, 9(2), 311.
Authors:  Malampati, Sandeep;  Song, Ju Xian;  Chun-Kit Tong, Benjamin;  Nalluri, Anusha;  Yang, Chuan Bin; et al.
Favorite | TC[WOS]:38 TC[Scopus]:38  IF:5.1/6.0 | Submit date：2021/12/03
Aggregates  Aggrephagy  Alzheimer’s Disease  Selective Autophagy  
Balancing mTOR signaling and autophagy in the treatment of Parkinson’s disease Journal article
Zhu,Zhou, Yang,Chuanbin, Iyaswamy,Ashok, Krishnamoorthi,Senthilkumar, Sreenivasmurthy,Sravan Gopalkrishnashetty, Liu,Jia, Wang,Ziying, Tong,Benjamin Chun Kit, Song,Juxian, Lu,Jiahong, Cheung,King Ho, Li,Min. Balancing mTOR signaling and autophagy in the treatment of Parkinson’s disease[J]. International Journal of Molecular Sciences, 2019, 20(3), 728.
Authors:  Zhu,Zhou;  Yang,Chuanbin;  Iyaswamy,Ashok;  Krishnamoorthi,Senthilkumar;  Sreenivasmurthy,Sravan Gopalkrishnashetty; et al.
Favorite | TC[WOS]:165 TC[Scopus]:172 | Submit date：2021/03/02
Autophagy  Mtor  Parkinson’s Disease