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Myricanol prevents aging-related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5 Journal article
Shen, Shengnan, Liao, Qiwen, Lyu, Peng, Wang, Jigang, Lin, Ligen. Myricanol prevents aging-related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5[J]. MedComm, 2024, 5(6), e566.
Authors:  Shen, Shengnan;  Liao, Qiwen;  Lyu, Peng;  Wang, Jigang;  Lin, Ligen
Favorite | TC[WOS]:0 TC[Scopus]:0 | Submit date：2024/07/04
Healthy Aging  Mitochondria  Myricanol  Peroxiredoxin 5  Redox Homeostasis  Sarcopenia  
G protein-coupled receptor-biased signaling: potential drug discovery to facilitate treatment of metabolic diseases Journal article
Shen, Shengnan, Liao, Qiwen, Gu, Liwei, Zhu, Yongping, Liu, Yanqing, Zhang, Xinwei, Zhang, Junzhe, Shi, Qiaoli, Sun, Yuxiang, Wang, Jigang, Lin, Ligen. G protein-coupled receptor-biased signaling: potential drug discovery to facilitate treatment of metabolic diseases[J]. Acta Materia Medica, 2024, 3(1), 31-45.
Authors:  Shen, Shengnan;  Liao, Qiwen;  Gu, Liwei;  Zhu, Yongping;  Liu, Yanqing; et al.
Favorite | TC[Scopus]:2 | Submit date：2024/07/04
Biased Signaling  Drug Target  Energy Homeostasis  Gpcr  Obesity  
Mitochondrial protection by a small molecule targeting peroxiredoxin-5 against Sarcopenia Conference paper
Shen Shengnan, Lyu, Peng, Wang Jigang, LIN LIGEN. Mitochondrial protection by a small molecule targeting peroxiredoxin-5 against Sarcopenia[C], 2023.
Authors:  Shen Shengnan;  Lyu, Peng;  Wang Jigang;  LIN LIGEN
Favorite |  | Submit date：2024/07/29
Modulation of Atg genes expression in aged rat liver, brain, and kidney by caloric restriction analyzed via single-nucleus/cell RNA sequencing Other
2023-02-01
Authors:  Yang,Chuanbin;  Xia,Siyu;  Zhang,Wei;  Shen,Han Ming;  Wang,Jigang
Favorite | TC[WOS]:5 TC[Scopus]:8 | Submit date：2023/08/03
Aging  Atgs  Autophagy  Brain  Caloric Restriction (Cr)  Kidney  Liver  Longevity  Single-cell Rna Sequencing  
Tributyltin chloride (TBTCL) induces cell injury via dysregulation of endoplasmic reticulum stress and autophagy in Leydig cells Journal article
Chen, Pengchen, Song, Yali, Tang, Li, Zhong, Wenbin, Zhang, Jing Jing, Cao, Min, Chen, Junhui, Cheng, Guangqing, Li, Huiying, Fan, Tianyun, Kwok, Hang Fai, Wang, Jigang, Yang, Chuanbin, Xiao, Wei. Tributyltin chloride (TBTCL) induces cell injury via dysregulation of endoplasmic reticulum stress and autophagy in Leydig cells[J]. Journal of Hazardous Materials, 2023, 448, 130785.
Authors:  Chen, Pengchen;  Song, Yali;  Tang, Li;  Zhong, Wenbin;  Zhang, Jing Jing; et al.
Favorite | TC[WOS]:7 TC[Scopus]:7  IF:12.2/11.9 | Submit date：2023/02/28
Tributyltin Chloride  Leydig Cell  Endoplasmic Reticulum Stress  Autophagy  
Mechanistic insights into the clinical Y96D mutation with acquired resistance to AMG510 in the KRASG12C Journal article
Zhuang, Haiming, Fan, Jigang, Li, Mingyu, Zhang, Hao, Yang, Xiuyan, Lin, Ligen, Lu, Shaoyong, Wang, Qing, Liu, Yaqin. Mechanistic insights into the clinical Y96D mutation with acquired resistance to AMG510 in the KRASG12C[J]. Frontiers in Oncology, 2022, 12, 915512.
Authors:  Zhuang, Haiming;  Fan, Jigang;  Li, Mingyu;  Zhang, Hao;  Yang, Xiuyan; et al.
Favorite | TC[WOS]:7 TC[Scopus]:6  IF:3.5/4.0 | Submit date：2022/09/07
Amg510  Drug Resistance  G12c  Kras  Molecular Dynamics Simulations  
Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential Journal article
Wei Zhang, Chengchao Xu, Jichao Sun, Han-Ming Shen, Jigang Wang, Chuanbin Yang. Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential[J]. Acta Pharmaceutica Sinica B, 2022, 12(3), 1019-1040.
Authors:  Wei Zhang;  Chengchao Xu;  Jichao Sun;  Han-Ming Shen;  Jigang Wang; et al.
Favorite | TC[WOS]:82 TC[Scopus]:84  IF:14.7/14.1 | Submit date：2022/04/06
Alzheimer’s Disease (Ad)  Amyloid Beta (Ab) Peptides  Mapt/tau  Autophagy–lysosomal Pathway  Autophagy Enhancers  Autophagy  Mitophagy  Neurodegenerative Diseases  
O-GlcNAcylation promotes fatty acid synthase activity under nutritional stress as a pro-survival mechanism in cancer cells Journal article
Wong, Yin Kwan, Wang, Jigang, Lim, Teck Kwang, Lin, Qingsong, Yap, Celestial T., Shen, Han Ming. O-GlcNAcylation promotes fatty acid synthase activity under nutritional stress as a pro-survival mechanism in cancer cells[J]. Proteomics, 2022, 22(9).
Authors:  Wong, Yin Kwan;  Wang, Jigang;  Lim, Teck Kwang;  Lin, Qingsong;  Yap, Celestial T.; et al.
Favorite | TC[WOS]:11 TC[Scopus]:11  IF:3.4/3.9 | Submit date：2022/05/13
Fatty Acid Synthase  Itraq  Liquid Chromatography – Tandem Mass Spectrometry  Metabolic Labelling  O-glcnac  
The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer’s disease Review article
2022
Authors:  Shen, Shengnan;  Liao, Qiwen;  Wong, Yin Kwan;  Chen, Xiao;  Yang, Chuanbin; et al.
Favorite | TC[WOS]:35 TC[Scopus]:36  IF:8.2/8.3 | Submit date：2022/05/17
Alzheimer’s Disease  Anti-inflammatory  Insulin Resistance  Melatonin  Mitochondria  Type 2 Diabetes  
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy Journal article
Tang, Yancheng, Wang, Liming, Yi, Tao, Xu, Jun, Wang, Jigang, Qin, Jiang Jiang, Chen, Qilei, Yip, Ka Man, Pan, Yihang, Hong, Peng, Lu, Yingying, Shen, Han Ming, Chen, Hu Biao. Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy[J]. Acta Pharmaceutica Sinica B, 2021, 11(12), 3966 - 3982.
Authors:  Tang, Yancheng;  Wang, Liming;  Yi, Tao;  Xu, Jun;  Wang, Jigang; et al.
Favorite | TC[WOS]:30 TC[Scopus]:32  IF:14.7/14.1 | Submit date：2021/11/30
Apoptosis  Combination Therapy  Magnolol  Pink1‒parkin-mediated Mitophagy  Tumor Suppression