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A new invertebrate NPY-like polypeptide, ZoaNPY, from the Zoanthus sociatus, as a novel ligand of human NPY Y2 receptor rescues vascular insufficiency via PLC/PKC and Src- FAK-dependent signaling pathways Journal article
Chen, Qian, Xu, Nan, Zhao, Chen, He, Yulin, Kam, Sandy Hio Tong, Wu, Xue, Huang, Pan, Yang, Min, Wong, Clarence Tsun Ting, Radis-Baptista, Gandhi, Tang, Benqin, Fan, Guangyi, Gong, Guiyi, Lee, Simon Ming Yuen. A new invertebrate NPY-like polypeptide, ZoaNPY, from the Zoanthus sociatus, as a novel ligand of human NPY Y2 receptor rescues vascular insufficiency via PLC/PKC and Src- FAK-dependent signaling pathways[J]. Pharmacological Research, 2024, 203, 107173.
Authors:  Chen, Qian;  Xu, Nan;  Zhao, Chen;  He, Yulin;  Kam, Sandy Hio Tong; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:9.1/9.0 | Submit date：2024/05/16
Angiogenesis  Cnidarian  Invertebrate Neuropeptide y  Npy Y2r  Transcriptome  
TRPV1 Modulator Ameliorates Alzheimer-Like Amyloid- β Neuropathology via Akt/Gsk3 β -Mediated Nrf2 Activation in the Neuro-2a/APP Cell Model Journal article
Wang, Xiufen, Bian, Yaqi, Clarence Tsun Ting Wong, Lu, Jia Hong, Lee, Simon Ming Yuen. TRPV1 Modulator Ameliorates Alzheimer-Like Amyloid- β Neuropathology via Akt/Gsk3 β -Mediated Nrf2 Activation in the Neuro-2a/APP Cell Model[J]. Oxidative Medicine and Cellular Longevity, 2022, 2022, 1544244.
Authors:  Wang, Xiufen;  Bian, Yaqi;  Clarence Tsun Ting Wong;  Lu, Jia Hong;  Lee, Simon Ming Yuen
Favorite | TC[WOS]:4 TC[Scopus]:5  IF:7.310/8.427 | Submit date：2023/01/30
Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis Journal article
Chen, Hanbin, Siu, Shirley Weng In, Wong, Clarence Tsun Ting, Qiu, Jianwen, Cheung, Alex Kwok Kuen, Lee, Simon Ming Yuen. Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis[J]. Archives of Toxicology, 2022, 96(9), 2589-2608.
Authors:  Chen, Hanbin;  Siu, Shirley Weng In;  Wong, Clarence Tsun Ting;  Qiu, Jianwen;  Cheung, Alex Kwok Kuen; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:4.8/5.3 | Submit date：2022/08/05
Anti-epileptic  Gabaa  Kunitz Peptide  Transcriptome  
Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae Journal article
Wang, Xiufen, Liao, Qiwen, Chen, Hanbin, Gong, Guiyi, Siu, Shirley Weng In, Chen, Qian, Kam, Hiotong, Ung, Carolina Oi Lam, Cheung, Kwok Kuen, Rádis-Baptista, Gandhi, Wong, Clarence Tsun Ting, Lee, Simon Ming Yuen. Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae[J]. Frontiers in Pharmacology, 2021, 12.
Authors:  Wang, Xiufen;  Liao, Qiwen;  Chen, Hanbin;  Gong, Guiyi;  Siu, Shirley Weng In; et al.
Favorite | TC[WOS]:3 TC[Scopus]:2  IF:4.4/5.0 | Submit date：2022/01/14
Anti-epilepsy  Pcactx Peptide  Transcriptomics Analysis  Trpv1 Channel  Zebrafish  Zoantharian  
Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia) Journal article
Qiwen Liao, Guiyi Gong, Terence C. W. Poon, Irene L. Ang, Kate M. K. Lei, Shirley Weng In Siu, Clarence Tsun Ting Wong, Gandhi Rádis-Baptista, Simon Ming-Yuen Lee. Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia)[J]. ARCHIVES OF TOXICOLOGY, 2019, 93(6), 1745-1767.
Authors:  Qiwen Liao;  Guiyi Gong;  Terence C. W. Poon;  Irene L. Ang;  Kate M. K. Lei; et al.
Favorite | TC[WOS]:18 TC[Scopus]:18  IF:4.8/5.3 | Submit date：2020/01/16
Cnidaria  Neuroprotection  Proteomic  Transcriptomic  Venom-derived Peptide  Zoantharian  
Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish Journal article
Qiwen Liao, Shengnan Li, Shirley Weng In Siu, Jean‑Étienne R. L. Morlighem, Clarence Tsun Ting Wong, Xiufen Wang, Gandhi Rádis‑Baptista, Simon Ming‑Yuen Lee. Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish[J]. Archives of Toxicology, 2018, 93(1), 189-206.
Authors:  Qiwen Liao;  Shengnan Li;  Shirley Weng In Siu;  Jean‑Étienne R. L. Morlighem;  Clarence Tsun Ting Wong; et al.
Favorite | TC[WOS]:13 TC[Scopus]:15  IF:4.8/5.3 | Submit date：2019/04/04
Anti-epilepsy  Disulfide Bond  Neuroactive Peptides  Neuroprotection  Protein Docking  Voltage-gated Sodium Ion Channel Blocker  
A novel ShK-like toxic peptide fromthe transcriptome of the cnidarian Palythoa caribaeorum displays neuroprotection and cardioprotection in zebrafish Journal article
Qiwen Liao, Guiyi Gong, Shirley Weng In Siu, Clarence Tsun Ting Wong, Huidong Yu, Yu Chung Tse, Gandhi Rádis-Baptista, Simon Ming-Yuen Lee. A novel ShK-like toxic peptide fromthe transcriptome of the cnidarian Palythoa caribaeorum displays neuroprotection and cardioprotection in zebrafish[J]. Toxins, 2018, 10(6).
Authors:  Qiwen Liao;  Guiyi Gong;  Shirley Weng In Siu;  Clarence Tsun Ting Wong;  Huidong Yu; et al.
Favorite | TC[WOS]:13 TC[Scopus]:14 | Submit date：2018/11/06
Animal Toxins  
A Novel ShK-Like Toxic Peptide from the Transcriptome of the Cnidarian Palythoa caribaeorum Displays Neuroprotection and Cardioprotection in Zebrafish Journal article
Liao, Qiwen, Gong, Guiyi, Siu, Shirley Weng In, Wong, Clarence Tsun Ting, Yu, Huidong, Tse, Yu Chung, Radis-Baptista, Gandhi, Lee, Simon Ming-Yuen. A Novel ShK-Like Toxic Peptide from the Transcriptome of the Cnidarian Palythoa caribaeorum Displays Neuroprotection and Cardioprotection in Zebrafish[J]. TOXINS, 2018, 10(6).
Authors:  Liao, Qiwen;  Gong, Guiyi;  Siu, Shirley Weng In;  Wong, Clarence Tsun Ting;  Yu, Huidong; et al.
Favorite |   IF:3.9/4.2 | Submit date：2018/10/30
Zoantharian  Shk-like Peptide  Dynamics Simulation  
Novel Kunitz-like Peptides Discovered in the Zoanthid Palythoa caribaeorum through Transcriptome Sequencing Journal article
Liao, Qiwen, Li, Shengnan, Siu, Shirley Weng In, Yang, Binrui, Huang, Chen, Chan, Judy Yuet-Wa, Morlighem, Jean-Etienne R. L., Wong, Clarence Tsun Ting, Radis-Baptista, Gandhi, Lee, Simon Ming-Yuen. Novel Kunitz-like Peptides Discovered in the Zoanthid Palythoa caribaeorum through Transcriptome Sequencing[J]. JOURNAL OF PROTEOME RESEARCH, 2018, 17(2), 891-902.
Authors:  Liao, Qiwen;  Li, Shengnan;  Siu, Shirley Weng In;  Yang, Binrui;  Huang, Chen; et al.
Favorite | TC[WOS]:22 TC[Scopus]:22  IF:3.8/4.1 | Submit date：2018/10/30
Soft Coral  Transcriptome  Kunitz-like Peptides  Protein Docking Zebrafish  Neurotoxin  Zoanthids