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A Mitochondria-Targeted Phenylbutyric Acid Prodrug Confers Drastically Improved Anticancer Activities Journal article
D. Huang, Q. Liu, M. Zhang, Y. Gao, Z. Cui, T. Li, D. Luo, B. Xu, C. Huang, J. Guo, K.Y. Tam, M. Zhang, S.L. Zhang, Y. He. A Mitochondria-Targeted Phenylbutyric Acid Prodrug Confers Drastically Improved Anticancer Activities[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65(14), 9955-9973.
Authors:  D. Huang;  Q. Liu;  M. Zhang;  Y. Gao;  Z. Cui; et al.
Favorite | TC[WOS]:11 TC[Scopus]:12  IF:6.8/7.1 | Submit date：2022/08/28
Lung-cancer  Breast  Derivatives  Inhibitor  
Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics Journal article
Zhang W., Hu X., Chakravarty H., Yang Z., Tam K.Y.. Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics[J]. ACS Combinatorial Science, 2018, 20(11), 660-671.
Authors:  Zhang W.;  Hu X.;  Chakravarty H.;  Yang Z.;  Tam K.Y.
Favorite | TC[WOS]:12 TC[Scopus]:12 | Submit date：2018/12/18
Cancer  High-throughput Screening  Pyruvate Dehydrogenase Kinase 1  Small Molecule Inhibitors  Warburg Effect  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Journal article
Zhang S.-L., Zhang W., Yang Z., Hu X., Tam K.Y.. Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells[J]. European Journal of Pharmaceutical Sciences, 2017, 110, 87-92.
Authors:  Zhang S.-L.;  Zhang W.;  Yang Z.;  Hu X.;  Tam K.Y.
Favorite | TC[WOS]:7 TC[Scopus]:7 | Submit date：2018/12/18
Anti-proliferation  Binding Affinity  Pyruvate Dehydrogenase Complex  Pyruvate Dehydrogenase Kinase  
Agrimonolide and desmethylagrimonolide induced HO-1 expression in HepG2 cells through Nrf2-transduction and p38 inactivation Journal article
Chen L., Teng H., Zhang K.Y., Skalicka-Wozniak K., Georgiev M.I., Xiao J.. Agrimonolide and desmethylagrimonolide induced HO-1 expression in HepG2 cells through Nrf2-transduction and p38 inactivation[J]. Frontiers in Pharmacology, 2017, 7(JAN).
Authors:  Chen L.;  Teng H.;  Zhang K.Y.;  Skalicka-Wozniak K.;  Georgiev M.I.; et al.
Favorite | TC[WOS]:25 TC[Scopus]:32 | Submit date：2019/01/15
Agrimonolide  Desmethylagrimonolide  Heme Oxygenase-1  Hepg2 Cells  Nrf2  P38 Mapk Signaling Pathway  
Quinazolinone azolyl ethanols: Potential lead antimicrobial agents with dual action modes targeting methicillin-resistant Staphylococcus aureus DNA Journal article
Peng X.-M., Peng L.-P., Li S., Avula S.R., Kannekanti V.K., Zhang S.-L., Tam K.Y., Zhou C.-H.. Quinazolinone azolyl ethanols: Potential lead antimicrobial agents with dual action modes targeting methicillin-resistant Staphylococcus aureus DNA[J]. Future Medicinal Chemistry, 2016, 8(16), 1927-1940.
Authors:  Peng X.-M.;  Peng L.-P.;  Li S.;  Avula S.R.;  Kannekanti V.K.; et al.
Favorite | TC[WOS]:59 TC[Scopus]:59 | Submit date：2018/12/18
Antibacterial  Antifungal  Dna Cleavage  Dna Intercalation  Imidazole  Quinazolinone  Triazole  
Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase to Inhibit Cancer Proliferation Journal article
Zhang S.-L., Hu X., Zhang W., Tam K.Y.. Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase to Inhibit Cancer Proliferation[J]. Journal of Medicinal Chemistry, 2016, 59(7), 3562-3568.
Authors:  Zhang S.-L.;  Hu X.;  Zhang W.;  Tam K.Y.
Favorite | TC[WOS]:44 TC[Scopus]:46 | Submit date：2018/12/18
Development of dichloroacetamide pyrimidines as pyruvate dehydrogenase kinase inhibitors to reduce cancer cell growth: Synthesis and biological evaluation Journal article
Zhang S.-L., Zhang W., Xiao Q., Yang Z., Hu X., Wei Z., Tam K.Y.. Development of dichloroacetamide pyrimidines as pyruvate dehydrogenase kinase inhibitors to reduce cancer cell growth: Synthesis and biological evaluation[J]. RSC Advances, 2016, 6(82), 78762-78767.
Authors:  Zhang S.-L.;  Zhang W.;  Xiao Q.;  Yang Z.;  Hu X.; et al.
Favorite | TC[WOS]:4 TC[Scopus]:5 | Submit date：2018/12/18
Specific frequency bands of amplitude low-frequency fluctuations in memory-related cognitive impairment: Predicting Alzheimer's disease Journal article
Tian Y., Ding Z., Tam K.Y., Wang Z., Zhang H., Zhao D., Zhao Y., Xu W., Zheng S.. Specific frequency bands of amplitude low-frequency fluctuations in memory-related cognitive impairment: Predicting Alzheimer's disease[J]. ADMET and DMPK, 2015, 3(3), 274-280.
Authors:  Tian Y.;  Ding Z.;  Tam K.Y.;  Wang Z.;  Zhang H.; et al.
Favorite | TC[WOS]:0 TC[Scopus]:1 | Submit date：2018/12/18
Ad  Alff  Rs-fmri  Top-down Modulation  Vlpfc  
Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP Journal article
Zhang S.-L., Yao H., Wang C., Tam K.Y.. Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP[J]. Bioorganic and Medicinal Chemistry Letters, 2014, 24(21), 4963-4968.
Authors:  Zhang S.-L.;  Yao H.;  Wang C.;  Tam K.Y.
Favorite | TC[WOS]:17 TC[Scopus]:17 | Submit date：2018/12/18
Binding Affinity  Fluconazole  Fluorescence Spectrum  Human Serum Albumin  Molecular Docking  
Bandwidth reservation using velocity and handoff statistics for cellular networks Journal article
Zhang C.-L., Lam K.Y., Jia W.-J.. Bandwidth reservation using velocity and handoff statistics for cellular networks[J]. Journal of Computer Science and Technology, 2006, 21(6), 1031-1039.
Authors:  Zhang C.-L.;  Lam K.Y.;  Jia W.-J.
Favorite | TC[WOS]:0 TC[Scopus]:0 | Submit date：2019/02/11
Bandwidth Reservation  Forced Termination Rate  Mobile Communication