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Dual inhibitors of DNMT and HDAC remodels the immune microenvironment of colorectal cancer and enhances the efficacy of anti-PD-L1 therapy Journal article
Yang ZhanBo, Chu BiZhu, Tu Yao, Li LuLu, Chen DaWei, Huang ShouHui, Huang WenJun, Fan WeiWen, Li QinYuan, Zhang CunLong, Yuan ZiGao, Huang Jumin, Leung Elaine Lai Han, Jiang Yuyang. Dual inhibitors of DNMT and HDAC remodels the immune microenvironment of colorectal cancer and enhances the efficacy of anti-PD-L1 therapy[J]. Pharmacological Research, 2024, 206, 107271.
Authors:  Yang ZhanBo;  Chu BiZhu;  Tu Yao;  Li LuLu;  Chen DaWei; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:9.1/9.0 | Submit date：2024/06/17
Dnmt  Hdac  Rig-i/mda5-mavs  Anti-pd-l1 Therapy  Tumor Immune Microenvironment  
ADCY4 promotes brain metastasis in small cell lung cancer and is associated with energy metabolism Journal article
Sun, Yidan, Chen, Yixun, Zhang, Xin, Yi, Dan, Kong, Fanming, Zhao, Linlin, Liao, Dongying, Chen, Lei, Ma, Qianqian, Wang, Ziheng. ADCY4 promotes brain metastasis in small cell lung cancer and is associated with energy metabolism[J]. Heliyon, 2024, 10(7), e28162.
Authors:  Sun, Yidan;  Chen, Yixun;  Zhang, Xin;  Yi, Dan;  Kong, Fanming; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:3.4/3.9 | Submit date：2024/05/02
Adcy4  Anti-pd1  Bms  Mfuzz  Sclc  Wgcna  
A platinum@polymer-catechol nanobraker enables radio-immunotherapy for crippling melanoma tumorigenesis, angiogenesis, and radioresistance Journal article
Li, Wenxi, Yan, Jie, Tian, Hao, Li, Bei, Wang, Guohao, Sang, Wei, Zhang, Zhan, Zhang, Xuanjun, Dai, Yunlu. A platinum@polymer-catechol nanobraker enables radio-immunotherapy for crippling melanoma tumorigenesis, angiogenesis, and radioresistance[J]. Bioactive Materials, 2023, 22, 34-46.
Authors:  Li, Wenxi;  Yan, Jie;  Tian, Hao;  Li, Bei;  Wang, Guohao; et al.
Favorite | TC[WOS]:20 TC[Scopus]:20  IF:18.0/18.2 | Submit date：2023/05/02
Anti-angiogenesis  Anti-tumorigenesis  Melanoma Pd-1:Pd-l1 Interaction Blockade  Platinum@polymer-catechol Nanobrakers  Radio-sensitization Effect  
Regulation of IFN-γ-mediated PD-L1 expression by MYC in colorectal cancer with wild-type KRAS and TP53 and its clinical implications Journal article
Guo, Libin, Tang, Xiaoqiong, Wong, Sin Wa, Guo, Anyuan, Lin, Yao, Kwok, Hang Fai. Regulation of IFN-γ-mediated PD-L1 expression by MYC in colorectal cancer with wild-type KRAS and TP53 and its clinical implications[J]. Frontiers in Pharmacology, 2022, 13, 1022129.
Authors:  Guo, Libin;  Tang, Xiaoqiong;  Wong, Sin Wa;  Guo, Anyuan;  Lin, Yao; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:4.4/5.0 | Submit date：2023/01/30
Anti-pd-1  Ifn-γ  Kras  Myc  Pd-l1 Expression  Tp53  Ifn-gamma  
Synergistic combination of targeted nano-nuclear-reactors and anti-PD-L1 nanobodies evokes persistent T cell immune activation for cancer immunotherapy Journal article
Zhu, Lipeng, Li, Junnan, Guo, Ziang, Kwok, Hang Fai, Zhao, Qi. Synergistic combination of targeted nano-nuclear-reactors and anti-PD-L1 nanobodies evokes persistent T cell immune activation for cancer immunotherapy[J]. Journal of Nanobiotechnology, 2022, 20(1), 521.
Authors:  Zhu, Lipeng;  Li, Junnan;  Guo, Ziang;  Kwok, Hang Fai;  Zhao, Qi
Favorite | TC[WOS]:10 TC[Scopus]:12  IF:10.6/11.4 | Submit date：2023/01/30
Anti-pd-l1 Nanobody  Hypoxia Modulation  Immune-cold Tumors  Immunogenic Cell Death  Nano-nuclear-reactor  t Cell Immune Activation  
ICBatlas: A Comprehensive Resource for Depicting Immune Checkpoint Blockade Therapy Characteristics from Transcriptome Profiles Journal article
Mei Yang, Ya-Ru Miao, Gui-Yan Xie, Mei Luo, Hui Hu, Hang Fai Kwok, Jian Feng, Jian Feng. ICBatlas: A Comprehensive Resource for Depicting Immune Checkpoint Blockade Therapy Characteristics from Transcriptome Profiles[J]. Cancer Immunology Research, 2022, 10(11), 1398-1406.
Authors:  Mei Yang;  Ya-Ru Miao;  Gui-Yan Xie;  Mei Luo;  Hui Hu; et al.
Favorite | TC[WOS]:22 TC[Scopus]:20  IF:8.1/10.1 | Submit date：2022/12/01
Anti-pd-1  Safety  Immunotherapy  Predicts  
Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation Journal article
Cao, Dai, Chen, Die, Xia, Jiang Nan, Wang, Wen Yan, Zhu, Guo Yuan, Chen, Li Wen, Zhang, Chuantao, Tan, Bo, Li, Hui, Li, Ying Wei. Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation[J]. Biomedicine and Pharmacotherapy, 2022, 155.
Authors:  Cao, Dai;  Chen, Die;  Xia, Jiang Nan;  Wang, Wen Yan;  Zhu, Guo Yuan; et al.
Favorite | TC[WOS]:10 TC[Scopus]:10  IF:6.9/6.8 | Submit date：2023/01/31
Anti-tumor Immunity  Artesunate  Egfr-tki Resistance  Non-small-cell Lung Cancer  Pd-l1  Taz  
A “three musketeers” tactic for inclining interferon-γ as a comrade-in-arm to reinforce the synergistic-tumoricidal therapy Journal article
Li, Wenxi, Xie, Lisi, Ju, Yi, Zhang, Zhan, Li, Bei, Li, Jie, Sang, Wei, Wang, Guohao, Tian, Hao, Dai, Yunlu. A “three musketeers” tactic for inclining interferon-γ as a comrade-in-arm to reinforce the synergistic-tumoricidal therapy[J]. Nano Research, 2022, 15(4), 3458-3470.
Authors:  Li, Wenxi;  Xie, Lisi;  Ju, Yi;  Zhang, Zhan;  Li, Bei; et al.
Favorite | TC[WOS]:6 TC[Scopus]:6  IF:9.5/9.0 | Submit date：2022/05/04
Anti-pd-l1 (Apd-l1)  Ido-1 Inhibitor (Nlg919)  Interferon-γ (Ifn-γ)  Neutralization  Positive Anti-tumor Feedback Loop  Tumoricidal  
Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific smad4/pten mutant mice Journal article
Zhao, Ming, Quan, Yingyao, Zeng, Jianming, Lyu, Xueying, Wang, Haitao, Lei, Josh Haipeng, Feng, Yangyang, Xu, Jun, Chen, Qiang, Sun, Heng, Xu, Xiaoling, Lu, Ligong, Deng, Chu Xia. Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific smad4/pten mutant mice[J]. International Journal of Biological Sciences, 2021, 17(15), 4176-4191.
Authors:  Zhao, Ming;  Quan, Yingyao;  Zeng, Jianming;  Lyu, Xueying;  Wang, Haitao; et al.
Favorite | TC[WOS]:10 TC[Scopus]:9  IF:8.2/8.3 | Submit date：2022/05/13
Anti-pd1/pd-l1 Therapy  Cholangiocarcinoma  Exhausted t Cells  Inflammatory Cytokines  Tumor Microenvironment