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Novel Dichloroacetophenone-Based PDHK1 Inhibitors as Potent Anticancer Agents Journal article
Wu, Puhua, Zhang, Zhicheng, Zhou, Yan, Liu, Quan, Tam, Kin Yip, Su, Zhenhong. Novel Dichloroacetophenone-Based PDHK1 Inhibitors as Potent Anticancer Agents[J]. DRUG DESIGN DEVELOPMENT AND THERAPY, 2024, 18, 4661-4679.
Authors:  Wu, Puhua;  Zhang, Zhicheng;  Zhou, Yan;  Liu, Quan;  Tam, Kin Yip; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:4.7/4.8 | Submit date：2024/11/05
Pdhk1  Dichloroacetophenone  Allosteric Pocket  Anti-nsclc Activity  Tumor Xenograft Mouse Model  
Dual inhibitors of DNMT and HDAC remodels the immune microenvironment of colorectal cancer and enhances the efficacy of anti-PD-L1 therapy Journal article
Yang ZhanBo, Chu BiZhu, Tu Yao, Li LuLu, Chen DaWei, Huang ShouHui, Huang WenJun, Fan WeiWen, Li QinYuan, Zhang CunLong, Yuan ZiGao, Huang Jumin, Leung Elaine Lai Han, Jiang Yuyang. Dual inhibitors of DNMT and HDAC remodels the immune microenvironment of colorectal cancer and enhances the efficacy of anti-PD-L1 therapy[J]. Pharmacological Research, 2024, 206, 107271.
Authors:  Yang ZhanBo;  Chu BiZhu;  Tu Yao;  Li LuLu;  Chen DaWei; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:9.1/9.0 | Submit date：2024/06/17
Dnmt  Hdac  Rig-i/mda5-mavs  Anti-pd-l1 Therapy  Tumor Immune Microenvironment  
Natural polysaccharides regulate intestinal microbiota for inhibiting colorectal cancer Review article
2024
Authors:  Liu, Lili;  Li, Yinan;  Zheng, Xiaoting;  Huang, Rong;  Huang, Xiaoli; et al.
Favorite | TC[WOS]:0 TC[Scopus]:1  IF:3.4/3.9 | Submit date：2024/06/05
Anti-tumor  Colorectal Cancer  Gut Microbiome  Natural Polysaccharides  
Harnessing natural product polysaccharides against lung cancer and revisit its novel mechanism Journal article
Tian WangQi, Huang JuMin, Zhang WeiTong, Wang YiFan, Jin RuYi, Guo Hui, Tang YuPing, Wang YuWei, Lai HuanLing, Leung Elaine Lai Han. Harnessing natural product polysaccharides against lung cancer and revisit its novel mechanism[J]. Pharmacological Research, 2024, 199, 107034.
Authors:  Tian WangQi;  Huang JuMin;  Zhang WeiTong;  Wang YiFan;  Jin RuYi; et al.
Favorite | TC[WOS]:6 TC[Scopus]:7  IF:9.1/9.0 | Submit date：2024/02/22
Anti-tumor  Gut Microbiota  Immune System  Lung Cancer  Natural Product Polysaccharide  
Discovery of novel anti-tumor compounds targeting PARP-1 with induction of autophagy through in silico and in vitro screening Journal article
Shi, Danfeng, Pang, Qianqian, Qin, Qianyu, Yao, Xinsheng, Yao, Xiaojun, Yu, Yang. Discovery of novel anti-tumor compounds targeting PARP-1 with induction of autophagy through in silico and in vitro screening[J]. Frontiers in Pharmacology, 2022, 13.
Authors:  Shi, Danfeng;  Pang, Qianqian;  Qin, Qianyu;  Yao, Xinsheng;  Yao, Xiaojun; et al.
Favorite | TC[WOS]:3 TC[Scopus]:4  IF:4.4/5.0 | Submit date：2023/01/31
allosteric  anti-tumor  autophagy  in silico screening  PARP-1 inhibitor  
Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation Journal article
Cao, Dai, Chen, Die, Xia, Jiang Nan, Wang, Wen Yan, Zhu, Guo Yuan, Chen, Li Wen, Zhang, Chuantao, Tan, Bo, Li, Hui, Li, Ying Wei. Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation[J]. Biomedicine and Pharmacotherapy, 2022, 155.
Authors:  Cao, Dai;  Chen, Die;  Xia, Jiang Nan;  Wang, Wen Yan;  Zhu, Guo Yuan; et al.
Favorite | TC[WOS]:10 TC[Scopus]:10  IF:6.9/6.8 | Submit date：2023/01/31
Anti-tumor Immunity  Artesunate  Egfr-tki Resistance  Non-small-cell Lung Cancer  Pd-l1  Taz  
Apoptosis-Sensing Xenograft Zebrafish Tumor Model for Anticancer Evaluation of Redox-Responsive Cross-Linked Pluronic Micelles Journal article
Tao, Jinsong, Wei, Zhengjie, Cheng, Yaxin, Xu, Meng, Li, Qiuxia, Lee, Simon Ming Yuen, Ge, Wei, Luo, Kathy Qian, Wang, Xueqing, Zheng, Ying. Apoptosis-Sensing Xenograft Zebrafish Tumor Model for Anticancer Evaluation of Redox-Responsive Cross-Linked Pluronic Micelles[J]. ACS Applied Materials & Interfaces, 2022, 14(35), 39775-39786.
Authors:  Tao, Jinsong;  Wei, Zhengjie;  Cheng, Yaxin;  Xu, Meng;  Li, Qiuxia; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:8.3/8.7 | Submit date：2022/10/06
Xenograft Zebrafish Tumor Model  Pluronic Polymeric Micelles  Redox Response  Disulfide Cross-linking  Anti-cancer  Tumor Microenvironment  
A “three musketeers” tactic for inclining interferon-γ as a comrade-in-arm to reinforce the synergistic-tumoricidal therapy Journal article
Li, Wenxi, Xie, Lisi, Ju, Yi, Zhang, Zhan, Li, Bei, Li, Jie, Sang, Wei, Wang, Guohao, Tian, Hao, Dai, Yunlu. A “three musketeers” tactic for inclining interferon-γ as a comrade-in-arm to reinforce the synergistic-tumoricidal therapy[J]. Nano Research, 2022, 15(4), 3458-3470.
Authors:  Li, Wenxi;  Xie, Lisi;  Ju, Yi;  Zhang, Zhan;  Li, Bei; et al.
Favorite | TC[WOS]:6 TC[Scopus]:6  IF:9.5/9.0 | Submit date：2022/05/04
Anti-pd-l1 (Apd-l1)  Ido-1 Inhibitor (Nlg919)  Interferon-γ (Ifn-γ)  Neutralization  Positive Anti-tumor Feedback Loop  Tumoricidal  
Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific smad4/pten mutant mice Journal article
Zhao, Ming, Quan, Yingyao, Zeng, Jianming, Lyu, Xueying, Wang, Haitao, Lei, Josh Haipeng, Feng, Yangyang, Xu, Jun, Chen, Qiang, Sun, Heng, Xu, Xiaoling, Lu, Ligong, Deng, Chu Xia. Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific smad4/pten mutant mice[J]. International Journal of Biological Sciences, 2021, 17(15), 4176-4191.
Authors:  Zhao, Ming;  Quan, Yingyao;  Zeng, Jianming;  Lyu, Xueying;  Wang, Haitao; et al.
Favorite | TC[WOS]:10 TC[Scopus]:9  IF:8.2/8.3 | Submit date：2022/05/13
Anti-pd1/pd-l1 Therapy  Cholangiocarcinoma  Exhausted t Cells  Inflammatory Cytokines  Tumor Microenvironment  
Alpinia zerumbet(Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities Journal article
Maram Hussein Zahra, Tarek A.R. Salem, Bishoy El-Aarag, Nermeen Yosri, Samah EL-Ghlban, Kholoud Zaki, Amel H. Marei, Aida Abd El-Wahed, Aamer Saeed, Alfi Khatib, Mohamed F. AlAjmi, Abdulrahman M. Shathili, Jianbo Xiao, Shaden A. M. Khalifa, Hesham R. El-Seedi. Alpinia zerumbet(Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities[J]. MOLECULES, 2019, 24(13).
Authors:  Maram Hussein Zahra;  Tarek A.R. Salem;  Bishoy El-Aarag;  Nermeen Yosri;  Samah EL-Ghlban; et al.
Favorite | TC[WOS]:22 TC[Scopus]:24  IF:4.2/4.6 | Submit date：2020/04/24
5,6-dehydrokawain  Alpinia Zerumbet  Ehrlich Ascites Carcinoma  Anti-oxidant  Anti-tumor