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Inhibiting β-Amyloid-Associated Alzheimer’s Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue Journal article
Shengquan Hu, Rui Wang, Wei Cui, Zaijun Zhang, Shinghung Mak, Daping Xu, Chunglit Choi, Karl Wahkeung Tsim, Paul R. Carlier, Mingyuen Lee, Yifan Han. Inhibiting β-Amyloid-Associated Alzheimer’s Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue[J]. Journal of Molecular Neuroscience, 2015, 55(4), 1014.
Authors:  Shengquan Hu;  Rui Wang;  Wei Cui;  Zaijun Zhang;  Shinghung Mak; et al.
Favorite | TC[WOS]:15 TC[Scopus]:15 | Submit date：2018/10/30
Alzheimer’s Disease  Aβ Fibrils  Bis(12)-hupyridone  Cell Viability  Memory Impairment  Thioflavin t  
Intestinal Transport of Bis(12)-hupyridone in Caco-2 Cells andits Improved Permeability by the Surfactant Brij-35 Journal article
Hua Yu, Yue Qing Hu, Fanny C. F. Ip, Zhong Zuo, Yi Fan Han, Nancy Y. Ip. Intestinal Transport of Bis(12)-hupyridone in Caco-2 Cells andits Improved Permeability by the Surfactant Brij-35[J]. Biopharmaceutics & Drug Disposition, 2011, 32(3), 140–150.
Authors:  Hua Yu;  Yue Qing Hu;  Fanny C. F. Ip;  Zhong Zuo;  Yi Fan Han; et al.
Favorite | TC[WOS]:27 TC[Scopus]:28  IF:1.7/1.6 | Submit date：2019/01/24
Bis(12)-hupyridone  Absorption  P-glycoprotein  Multidrug Resistance-associated Protein  Nonionic Surfactant  
Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR Journal article
Cui, Wei, Cui, Guo-Zhen, Li, Wenming, Zhang, Zaijun, Hu, Shengquan, Mak, Shinghung, Zhang, Huan, Carlier, Paul R., Choi, Chung-lit, Wong, Yi-Tao, Lee, Simon Ming-Yuen, Han, Yifan. Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR[J]. BRAIN RESEARCH, 2011, 1401(15), 10-17.
Authors:  Cui, Wei;  Cui, Guo-Zhen;  Li, Wenming;  Zhang, Zaijun;  Hu, Shengquan; et al.
Favorite | TC[WOS]:22 TC[Scopus]:23  IF:2.7/2.9 | Submit date：2018/11/01
Bis(12)-hupyridone  Huperzine a  Neural Stem Cell  Neurodegenerative Disorder  Differentiation  Alpha 7nachr  
Development and validation of an HPLC-DAD method for bis(12)-hupyridone and its application to a pharmacokinetic study Journal article
Yu H., Li W.M., Cheung M.C., Zuo Z., Carlier P.R., Gu Z.M., Chan K., Huang M., Wang Y.T., Han Y.F.. Development and validation of an HPLC-DAD method for bis(12)-hupyridone and its application to a pharmacokinetic study[J]. Journal of Pharmaceutical and Biomedical Analysis, 2009, 49(2), 410.
Authors:  Yu H.;  Li W.M.;  Cheung M.C.;  Zuo Z.;  Carlier P.R.; et al.
Favorite | TC[WOS]:1 TC[Scopus]:2  IF:3.1/3.1 | Submit date：2018/10/31
Alzheimer's Disease  Bis(12)-hupyridone  Hplc-dad  Pharmacokinetics  
The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine Journal article
Yu H., Li W.-M., Kan K.K.W., Ho J.M.K., Carlier P.R., Pang Y.-P., Gu Z.-M., Zhong Z., Chan K., Wang Y.-T., Han Y.-F.. The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine[J]. Journal of Pharmaceutical and Biomedical Analysis, 2008, 46(1), 75.
Authors:  Yu H.;  Li W.-M.;  Kan K.K.W.;  Ho J.M.K.;  Carlier P.R.; et al.
Favorite | TC[WOS]:34 TC[Scopus]:43 | Submit date：2018/10/30
Ache Inhibition  Bis(12)-hupyridone  Bis(7)-tacrine  Dimer  Ionization Constant  Lipophilicity  Solubility