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Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry Journal article
Li, Z, Hu, Y, Ming, LW, Chun, CM, Ping, PY, Ge, L, Tao, WY, Zhong, Z, Fan, HY. Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry[J]. BIOMEDICAL CHROMATOGRAPHY, 2008, 22(4), 414-420.
Authors:  Li, Z;  Hu, Y;  Ming, LW;  Chun, CM;  Ping, PY; et al.
View | Adobe PDF | Favorite | TC[WOS]:6 TC[Scopus]:6  IF:1.8/1.8 | Submit date：2018/11/01
Bis(7)-tacrine  Alzheimer's Disease  Lc-ms-ms  Rat Plasma  
Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine Journal article
Zhang L., Yu H., Li W.M., Cheung M.C., Pang Y.P., Gu Z.M., Chan K., Wang Y.T., Zuo Z., Han Y.F.. Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine[J]. International Journal of Pharmaceutics, 2008, 357(2018-01-02), 85.
Authors:  Zhang L.;  Yu H.;  Li W.M.;  Cheung M.C.;  Pang Y.P.; et al.
Favorite | TC[WOS]:19 TC[Scopus]:20  IF:5.3/5.6 | Submit date：2018/10/31
Bis(7)-tacrine  Intestinal Absorption  Metabolism  
The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine Journal article
Yu H., Li W.-M., Kan K.K.W., Ho J.M.K., Carlier P.R., Pang Y.-P., Gu Z.-M., Zhong Z., Chan K., Wang Y.-T., Han Y.-F.. The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine[J]. Journal of Pharmaceutical and Biomedical Analysis, 2008, 46(1), 75.
Authors:  Yu H.;  Li W.-M.;  Kan K.K.W.;  Ho J.M.K.;  Carlier P.R.; et al.
Favorite | TC[WOS]:34 TC[Scopus]:43 | Submit date：2018/10/30
Ache Inhibition  Bis(12)-hupyridone  Bis(7)-tacrine  Dimer  Ionization Constant  Lipophilicity  Solubility  
Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons Journal article
Hongjun Fu, Wenming Li, Yulin Liu, Yuanzhi Lao, Wei Liu, Cheng Chen, Hua Yu, Nelson T. K. Lee, Donald C. Chang, Peng Li, Yuanping Pang, Karl W. K. Tsim, Mingtao Li, Yifan Han. Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons[J]. JOURNAL OF PROTEOME RESEARCH, 2007, 6(7), 2435-2446.
Authors:  Hongjun Fu;  Wenming Li;  Yulin Liu;  Yuanzhi Lao;  Wei Liu; et al.
Favorite | TC[WOS]:30 TC[Scopus]:33  IF:3.8/4.1 | Submit date：2020/03/12
Bis(7)-tacrine  Glutamate  Mitochondria  Cerebellar Granule Neurons  Two-dimensional Differential In-gel Electrophoresis  Maldi-tof/ms  
Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer’s dimer, in rat blood Journal article
Yu, H, Ho, JMK, Kan, KKW, Cheng, BWH, Li, WM, Zhang, L, Lin, G, Pang, YP, Gu, ZM, Chan, K, Wang, YT, Han, YF. Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer’s dimer, in rat blood[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2007, 44(5), 1133-1138.
Authors:  Yu, H;  Ho, JMK;  Kan, KKW;  Cheng, BWH;  Li, WM; et al.
View | Adobe PDF | Favorite | TC[WOS]:4 TC[Scopus]:5  IF:3.1/3.1 | Submit date：2018/11/01
Bis(7)-tacrine  Dimer  Alzheimer's Disease  Hplc-ms/ms  Drug Monitoring  Pharmacokinetics