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Dual-target inhibitors of cholinesterase and GSK-3beta to modulate Alzheimer's disease Journal article
He Junqiu, TAM KIN YIP. Dual-target inhibitors of cholinesterase and GSK-3beta to modulate Alzheimer's disease[J]. Drug Discovery Today, 2024, 29(4), 1-8.
Authors:  He Junqiu;  TAM KIN YIP
Adobe PDF | Favorite | TC[WOS]:2 TC[Scopus]:3  IF:6.5/7.3 | Submit date：2024/08/29
Gsk-3b  Cholinesterase  Dual-target Inhibitors  Alzheimer’s Disease  Drug Design Strategy  
Dual-target inhibitors of cholinesterase and GSK-3β to modulate Alzheimer's disease Other
2024-04-01
Authors:  He, Junqiu;  Tam, Kin Yip
Favorite | TC[WOS]:2 TC[Scopus]:3 | Submit date：2024/05/02
Alzheimer's Disease  Cholinesterase  Drug Design Strategy  Dual-target Inhibitors  Gsk-3β  
G protein-coupled receptor-biased signaling: potential drug discovery to facilitate treatment of metabolic diseases Journal article
Shen, Shengnan, Liao, Qiwen, Gu, Liwei, Zhu, Yongping, Liu, Yanqing, Zhang, Xinwei, Zhang, Junzhe, Shi, Qiaoli, Sun, Yuxiang, Wang, Jigang, Lin, Ligen. G protein-coupled receptor-biased signaling: potential drug discovery to facilitate treatment of metabolic diseases[J]. Acta Materia Medica, 2024, 3(1), 31-45.
Authors:  Shen, Shengnan;  Liao, Qiwen;  Gu, Liwei;  Zhu, Yongping;  Liu, Yanqing; et al.
Favorite | TC[Scopus]:2 | Submit date：2024/07/04
Biased Signaling  Drug Target  Energy Homeostasis  Gpcr  Obesity  
A novel combination treatment of antiADAM17 antibody and erlotinib to overcome acquired drug resistance in non-small cell lung cancer through the FOXO3a/FOXM1 axis Journal article
Li, Junnan, Chen, Pengchen, Wu, Qiushuang, Guo, Libin, Leong, Ka Weng, Chan, Kin Iong, Kwok, Hang Fai. A novel combination treatment of antiADAM17 antibody and erlotinib to overcome acquired drug resistance in non-small cell lung cancer through the FOXO3a/FOXM1 axis[J]. Cellular and Molecular Life Sciences, 2022, 79(12), 614.
Authors:  Li, Junnan;  Chen, Pengchen;  Wu, Qiushuang;  Guo, Libin;  Leong, Ka Weng; et al.
Favorite | TC[WOS]:7 TC[Scopus]:6  IF:6.2/7.7 | Submit date：2023/01/30
Antibody Therapy  Cell Death  Drug Target  Precision Oncology  Small Molecule  
The development of small-molecule inhibitors targeting hexokinase 2 Journal article
Shen Wenying, Zhou Yan, TAM KIN YIP. The development of small-molecule inhibitors targeting hexokinase 2[J]. Drug Discovery Today, 2022, 27(9), 2574-2585.
Authors:  Shen Wenying;  Zhou Yan;  TAM KIN YIP
Adobe PDF | Favorite | TC[WOS]:22 TC[Scopus]:20  IF:6.5/7.3 | Submit date：2024/08/29
Cancer Metabolism  Hexokinase 2  Drug–target Binding  Selective Inhibition  Structure-based Molecular Design  
Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein Journal article
Gao, Zhenxiong, Fan, Tingting, Chen, Linbo, Yang, Mengchu, Wai Wong, Vincent Kam, Chen, Dawei, Liu, Zijian, Zhou, Yaoyao, Wu, Weibin, Qiu, Zixuan, Zhang, Cunlong, Li, Yuan, Jiang, Yuyang. Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein[J]. European Journal of Medicinal Chemistry, 2022, 238.
Authors:  Gao, Zhenxiong;  Fan, Tingting;  Chen, Linbo;  Yang, Mengchu;  Wai Wong, Vincent Kam; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:6.0/6.1 | Submit date：2023/01/30
14-3-3η Protein  Antitumor Bioactivity  Drug Design  Hepatocellular Carcinoma  Novel Target  
Novel synovial targeting peptide-sinomenine conjugates as a potential strategy for the treatment of rheumatoid arthritis Journal article
Zhang, Tianyue, Ouyang, Xu, Gou, Sanhu, Zhang, Yun, Yan, Na, Chang, Linlin, Li, Beibei, Zhang, Fangyan, Liu, Hui, Ni, Jingman. Novel synovial targeting peptide-sinomenine conjugates as a potential strategy for the treatment of rheumatoid arthritis[J]. International Journal of Pharmaceutics, 2022, 617.
Authors:  Zhang, Tianyue;  Ouyang, Xu;  Gou, Sanhu;  Zhang, Yun;  Yan, Na; et al.
Favorite | TC[WOS]:11 TC[Scopus]:10  IF:5.3/5.6 | Submit date：2023/01/30
Peptide-drug Conjugates  Rheumatoid Arthritis  Sinomenine  Target Delivery  
The development of small-molecule inhibitors targeting hexokinase 2 Review article
2022
Authors:  Shan, Wenying;  Zhou, Yan;  Tam, Kin Yip
Favorite | TC[WOS]:22 TC[Scopus]:20  IF:6.5/7.3 | Submit date：2022/08/05
Cancer Metabolism  Hexokinase 2  Drug–target Binding  Selective Inhibition  Structure-based Molecular Design  
LigTMap: ligand and structure-based target identification and activity prediction for small molecular compounds Journal article
Shaikh, Faraz, Tai, Hio Kuan, Desai, Nirali, Siu, Shirley W.I.. LigTMap: ligand and structure-based target identification and activity prediction for small molecular compounds[J]. Journal of Cheminformatics, 2021, 13(1), 44.
Authors:  Shaikh, Faraz;  Tai, Hio Kuan;  Desai, Nirali;  Siu, Shirley W.I.
Favorite | TC[WOS]:15 TC[Scopus]:16  IF:7.1/9.3 | Submit date：2021/12/09
Binding Affinity Prediction  Binding Interaction Fingerprint  Drug Repurposing  Fingerprint Similarity  Inverse Docking  Psovina  Random Forest  Target Prediction  
Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies Review article
2020
Authors:  Liu, Peng;  Gao, Caifang;  Chen, Hongguo;  Vong, Chi Teng;  Wu, Xu; et al.
Favorite | TC[WOS]:81 TC[Scopus]:86  IF:14.7/14.1 | Submit date：2021/09/13
Active Target  Cell Adhesion Molecule  Crohn's Disease  Drug Delivery  Inflammatory Bowel Disease  Receptor-mediated Target  Targeted Therapy  Ulcerative Colitis