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Multiple initiatives to conquer KRAS G12C inhibitor resistance from the perspective of clinical therapy Journal article
Zhang JunMin, Zhang JuanHong, Leung Elaine Lai Han, Yao XiaoJun. Multiple initiatives to conquer KRAS G12C inhibitor resistance from the perspective of clinical therapy[J]. EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2023, 32(2), 101-106.
Authors:  Zhang JunMin;  Zhang JuanHong;  Leung Elaine Lai Han;  Yao XiaoJun
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:4.9/5.3 | Submit date：2023/06/15
Kras G12c  Amg 510  Mrtx 849  Targeted Therapy  Drug Resistance  
In Silico Study of the Acquired Resistance Caused by the Secondary Mutations of KRAS G12C Protein Using Long Time Molecular Dynamics Simulation and Markov State Model Analysis Journal article
Tu Gao, Liu Qing, Qiu Yue, Leung Elaine Lai Han, Yao XiaoJun. In Silico Study of the Acquired Resistance Caused by the Secondary Mutations of KRAS G12C Protein Using Long Time Molecular Dynamics Simulation and Markov State Model Analysis[J]. International Journal of Molecular Sciences, 2022, 23(22), 13845.
Authors:  Tu Gao;  Liu Qing;  Qiu Yue;  Leung Elaine Lai Han;  Yao XiaoJun
Favorite | TC[WOS]:6 TC[Scopus]:8 | Submit date：2023/01/31
Kras G12c Inhibitor  Drug Resistance  Molecular Dynamics  Markov State Model  
Mechanistic insights into the clinical Y96D mutation with acquired resistance to AMG510 in the KRASG12C Journal article
Zhuang, Haiming, Fan, Jigang, Li, Mingyu, Zhang, Hao, Yang, Xiuyan, Lin, Ligen, Lu, Shaoyong, Wang, Qing, Liu, Yaqin. Mechanistic insights into the clinical Y96D mutation with acquired resistance to AMG510 in the KRASG12C[J]. Frontiers in Oncology, 2022, 12, 915512.
Authors:  Zhuang, Haiming;  Fan, Jigang;  Li, Mingyu;  Zhang, Hao;  Yang, Xiuyan; et al.
Favorite | TC[WOS]:7 TC[Scopus]:6  IF:3.5/4.0 | Submit date：2022/09/07
Amg510  Drug Resistance  G12c  Kras  Molecular Dynamics Simulations