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G protein-coupled receptor-biased signaling: potential drug discovery to facilitate treatment of metabolic diseases Journal article
Shen, Shengnan, Liao, Qiwen, Gu, Liwei, Zhu, Yongping, Liu, Yanqing, Zhang, Xinwei, Zhang, Junzhe, Shi, Qiaoli, Sun, Yuxiang, Wang, Jigang, Lin, Ligen. G protein-coupled receptor-biased signaling: potential drug discovery to facilitate treatment of metabolic diseases[J]. Acta Materia Medica, 2024, 3(1), 31-45.
Authors:  Shen, Shengnan;  Liao, Qiwen;  Gu, Liwei;  Zhu, Yongping;  Liu, Yanqing; et al.
Favorite | TC[Scopus]:2 | Submit date：2024/07/04
Biased Signaling  Drug Target  Energy Homeostasis  Gpcr  Obesity  
Gαq Is the Specific Mediator of PAR-1 Transactivation of Kinase Receptors in Vascular Smooth Muscle Cells Journal article
Danielle Kamato, Mai Gabr, Hirushi Kumarapperuma, Zheng J. Chia, Wenhua Zheng, Suowen Xu, Narin Osman, Peter J. Little. Gαq Is the Specific Mediator of PAR-1 Transactivation of Kinase Receptors in Vascular Smooth Muscle Cells[J]. International Journal of Molecular Sciences, 2022, 23(22), 14425.
Authors:  Danielle Kamato;  Mai Gabr;  Hirushi Kumarapperuma;  Zheng J. Chia;  Wenhua Zheng; et al.
Favorite | TC[WOS]:2 TC[Scopus]:3 | Submit date：2023/01/31
Epidermal Growth Factor Receptor  Transforming Growth Factor Type i Receptor  Transactivation Dependent  Gpcr  Thrombin  Proteoglycans  
GIP receptor suppresses PAC1receptor-mediated neuronal differentiation via formation of a receptor heterocomplex Journal article
Ke, Ran, Lok, Samson I.S., Singh, Kailash, Chow, Billy K.C., Lee, Leo T.O.. GIP receptor suppresses PAC1receptor-mediated neuronal differentiation via formation of a receptor heterocomplex[J]. Journal of Neurochemistry, 2020, 157(6), 1850-1860.
Authors:  Ke, Ran;  Lok, Samson I.S.;  Singh, Kailash;  Chow, Billy K.C.;  Lee, Leo T.O.
Favorite | TC[WOS]:1 TC[Scopus]:0  IF:4.2/4.9 | Submit date：2021/12/08
Gastric Inhibitory Polypeptide Receptor  Gpcr Heterodimerization  Neuronal Differentiation  Pacap Receptor  
FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell proliferation and differentiation Journal article
Zheng, Can, Chen, Dixin, Zhang, Yan, Bai, Yun, Huang, Shiyang, Zheng, Danfeng, Liang, Weiwei, She, Shaoping, Peng, Xinjian, Wang, Pingzhang, Mo, Xiaoning, Song, Quansheng, Lv, Ping, Huang, Jing, Ye, Richard D., Wang, Ying. FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell proliferation and differentiation[J]. FASEB JOURNAL, 2018, 32(11), 5874-5890.
Authors:  Zheng, Can;  Chen, Dixin;  Zhang, Yan;  Bai, Yun;  Huang, Shiyang; et al.
Favorite | TC[WOS]:25 TC[Scopus]:25  IF:4.4/4.7 | Submit date：2018/10/31
Neural Stem Cell  Gpcr  Cytokines  
Application of Nanoparticles for Targeting G Protein-Coupled Receptors Journal article
Ma, Xin, Xiong, Yunfang, Lee, Leo Tsz On. Application of Nanoparticles for Targeting G Protein-Coupled Receptors[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19(7).
Authors:  Ma, Xin;  Xiong, Yunfang;  Lee, Leo Tsz On
Favorite | TC[WOS]:26 TC[Scopus]:25 | Submit date：2018/10/30
g Protein-coupled Receptor (Gpcr)  Cancer  Nanoparticles (Nps)  Dendrimers  Quantum Dots (Qds)  Gold Nanoparticles (Aunps)  Magnetic Nanoparticles (Mnps)  
The Role of G Protein-coupled Receptor Kinases in Cancer Journal article
Yu, Shan, Sun, Litao, Jiao, Yufei, Lee, Leo Tsz On. The Role of G Protein-coupled Receptor Kinases in Cancer[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018, 14(2), 189-203.
Authors:  Yu, Shan;  Sun, Litao;  Jiao, Yufei;  Lee, Leo Tsz On
Favorite | TC[WOS]:41 TC[Scopus]:43  IF:8.2/8.3 | Submit date：2018/10/30
g Protein-coupled Receptor (Gpcr)  g Protein-coupled Receptor Kinase (Grk)  Cancer  Cell Signaling  
Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR-1 signalling Journal article
Zheng, W.. Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR-1 signalling[J]. Br J Pharmacol, 2016, 2992-3000.
Authors:  Zheng, W.
Favorite |   IF:6.8/7.4 | Submit date：2022/08/31
GPCR transactivation-dependent  biased signalling paradigms  
Functional pairing of class B1 ligand-GPCR in cephalochordate provides evidence of the origin of PTH and PACAP/glucagon receptor family Journal article
On J.S.W., Duan C., Chow B.K.C., Lee L.T.O.. Functional pairing of class B1 ligand-GPCR in cephalochordate provides evidence of the origin of PTH and PACAP/glucagon receptor family[J]. Molecular Biology and Evolution, 2015, 32(8), 2048-2059.
Authors:  On J.S.W.;  Duan C.;  Chow B.K.C.;  Lee L.T.O.
Favorite | TC[WOS]:16 TC[Scopus]:16 | Submit date：2019/01/15
Amphioxus  Gpcr  Pacap/glucagon  Pth  
Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11 Journal article
Kamato,Danielle, Thach,Lyna, Bernard,Rebekah, Chan,Vincent, Zheng,Wenhua, Kaur,Harveen, Brimble,Margaret, Osman,Narin, Little,Peter J.. Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11[J]. Frontiers in Cardiovascular Medicine, 2015, 2.
Authors:  Kamato,Danielle;  Thach,Lyna;  Bernard,Rebekah;  Chan,Vincent;  Zheng,Wenhua; et al.
Favorite | TC[Scopus]:64  IF:2.8/3.1 | Submit date：2021/03/04
Cell Signaling  g Proteins  Gpcr  Therapeutic Targets  Transactivation  
Chemerin C9 peptide induces receptor internalization through a clathrin-independent pathway Journal article
Zhou J.-X., Liao D., Zhang S., Cheng N., He H.-Q., Ye R.D.. Chemerin C9 peptide induces receptor internalization through a clathrin-independent pathway[J]. Acta Pharmacologica Sinica, 2014, 35(5), 653-663.
Authors:  Zhou J.-X.;  Liao D.;  Zhang S.;  Cheng N.;  He H.-Q.; et al.
Favorite | TC[WOS]:24 TC[Scopus]:24 | Submit date：2018/11/07
Calcium Flux  Chemerin  Cmklr1  Endocytosis  Erk Phosphorylation  Gpcr  Receptor Internalization  Receptor Trafficking