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Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63-specific ubiquitination Journal article
Ding Moyu, Ning Chengqing, Chen Shaoru, Yin Haoran, Xu Jing, WANG YING. Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63-specific ubiquitination[J]. doi: 10.1111/bph.17320, 2024, 181(22), 1–18.
Authors:  Ding Moyu;  Ning Chengqing;  Chen Shaoru;  Yin Haoran;  Xu Jing; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:6.8/7.4 | Submit date：2024/10/06
Immunosuppressive Activity  Inflammasome-driven Disease  K63-linked Ubiquitination,  Nlrp3  Triptolide Derivative  Triptolidiol  
Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin's neuroprotective action against diabetes-induced cognitive impairment Journal article
Zheng, Yanfang, Wang, Chenxiang, Liu, Wenjing, Chen, Jiaying, Sun, Yibin, Chang, Dennis, Wang, Huan, Xu, Wen, Lu, Jin Jian, Zhou, Xian, Huang, Mingqing. Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin's neuroprotective action against diabetes-induced cognitive impairment[J]. Biomedicine and Pharmacotherapy, 2024, 174, 116579.
Authors:  Zheng, Yanfang;  Wang, Chenxiang;  Liu, Wenjing;  Chen, Jiaying;  Sun, Yibin; et al.
Favorite | TC[WOS]:3 TC[Scopus]:4  IF:6.9/6.8 | Submit date：2024/05/16
Baicalin  Diabetes-associated Cognitive Deficits  Keap1-nrf2  Neuroinflammation  Nlrp3 Inflammasome  Oxidative Stress  
TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson’s Disease Mice and LPS-Induced BV2 Cells Journal article
Huang, Peiting, Zhang, Zhanyu, Zhang, Piao, Feng, Jiezhu, Xie, Jianwei, Zheng, Yinjuan, Liang, Xiaomei, Zhu, Baoyu, Chen, Zhenzhen, Feng, Shujun, Wang, Lijuan, Lu, Jiahong, Liu, Yawei, Zhang, Yuhu. TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson’s Disease Mice and LPS-Induced BV2 Cells[J]. Molecular Neurobiology, 2023, 61(5), 2590-2605.
Authors:  Huang, Peiting;  Zhang, Zhanyu;  Zhang, Piao;  Feng, Jiezhu;  Xie, Jianwei; et al.
Favorite | TC[WOS]:11 TC[Scopus]:12  IF:4.6/4.7 | Submit date：2024/02/22
Inflammasome  Nlrp3  Parkinson’s Disease  Pyroptosis  Trem2  
Targeting Inflammasome Activation in Viral Infection: A Therapeutic Solution? Journal article
Deng, Chuanhan, Li, Tianqi, Zhang, Wei, Zhao, Qi, Wang, Ying. Targeting Inflammasome Activation in Viral Infection: A Therapeutic Solution?[J]. Viruses, 2023, 15(7), 1451.
Authors:  Deng, Chuanhan;  Li, Tianqi;  Zhang, Wei;  Zhao, Qi;  Wang, Ying
Adobe PDF | Favorite | TC[WOS]:11 TC[Scopus]:7  IF:3.8/4.0 | Submit date：2023/06/28
Inflammasome  Viral Infection  Inflammatory Response  Innate Immunity  Host Defense  Therapy  
Ginsenoside Rk2, a dehydroprotopanaxadiol saponin, alleviates alcoholic liver disease via regulating NLRP3 and NLRP6 inflammasome signaling pathways in mice Journal article
Jian Zou, Rujie Yang, Ruibing Feng, Jiayue Liu, Jian Bo Wan. Ginsenoside Rk2, a dehydroprotopanaxadiol saponin, alleviates alcoholic liver disease via regulating NLRP3 and NLRP6 inflammasome signaling pathways in mice[J]. Journal of Pharmaceutical Analysis, 2023, 13(9), 999-1012.
Authors:  Jian Zou;  Rujie Yang;  Ruibing Feng;  Jiayue Liu;  Jian Bo Wan
Favorite | TC[WOS]:6 TC[Scopus]:6  IF:6.1/6.8 | Submit date：2023/10/10
Alcoholic Liver Disease  Ginsenoside Rk2  Intestinal Barrier Dysfunction  Nlrp3 Inflammasome  Nlrp6 Inflammasome  
Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19 Journal article
Yong, Yuan Yuan, Zhang, Li, Hu, Yu Jiao, Wu, Jian Ming, Yan, Lu, Pan, Yi Ru, Tang, Yong, Yu, Lu, Law, Betty Yuen Kwan, Yu, Chong Lin, Zhou, Jie, Li, Mao, Qin, Da Lian, Zhou, Xiao Gang, Wu, An Guo. Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19[J]. Clinical Immunology, 2022, 244.
Authors:  Yong, Yuan Yuan;  Zhang, Li;  Hu, Yu Jiao;  Wu, Jian Ming;  Yan, Lu; et al.
Favorite | TC[WOS]:9 TC[Scopus]:10  IF:4.5/4.7 | Submit date：2023/01/31
Autophagy Regulation  Covid-19  Lung Inflammation  Nlrp3 Inflammasome  Sars-cov-2  
Immunostimulatory activity and structure-activity relationship of epimedin B from Epimedium brevicornu Maxim. Journal article
Gao, Yuan, Shi, Wei, Tu, Can, Li, Peng, Zhao, Guanyu, Xiao, Xiaohe, Wang, Jiabo, Bai, Zhaofang. Immunostimulatory activity and structure-activity relationship of epimedin B from Epimedium brevicornu Maxim.[J]. Frontiers in Pharmacology, 2022, 13, 1015846.
Authors:  Gao, Yuan;  Shi, Wei;  Tu, Can;  Li, Peng;  Zhao, Guanyu; et al.
Favorite | TC[WOS]:8 TC[Scopus]:14  IF:4.4/5.0 | Submit date：2022/12/01
Epimedii Folium  Epimedin b  Idiosyncratic Drug-induced Liver Injury  Mitochondrial Ros  Nlrp3 Inflammasome  
14-Deoxygarcinol improves insulin sensitivity in high-fat diet-induced obese mice via mitigating NF-κB/Sirtuin 2-NLRP3-mediated adipose tissue remodeling Journal article
Jia-li Chen, Zhe-ling Feng, Fei Zhou, Ruo-han Lou, Cheng Peng, Yang Ye, Li-gen Lin. 14-Deoxygarcinol improves insulin sensitivity in high-fat diet-induced obese mice via mitigating NF-κB/Sirtuin 2-NLRP3-mediated adipose tissue remodeling[J]. Acta Pharmacologica Sinica, 2022, 44, 434–445.
Authors:  Jia-li Chen;  Zhe-ling Feng;  Fei Zhou;  Ruo-han Lou;  Cheng Peng; et al.
Favorite | TC[WOS]:10 TC[Scopus]:10  IF:6.9/7.6 | Submit date：2023/01/30
14-deoxygarcinol  Adipose Tissue Inflammation  Insulin Resistance  Interleukin-1β  Nlrp3 Inflammasome  Sirtuin 2  
Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease Journal article
Zhou, Xiao Gang, Qiu, Wen Qiao, Yu, Lu, Pan, Rong, Teng, Jin Feng, Sang, Zhi Pei, Law, Betty Yuen Kwan, Zhao, Ya, Zhang, Li, Yan, Lu, Tang, Yong, Sun, Xiao Lei, Wong, Vincent Kam Wai, Yu, Chong Lin, Wu, Jian Ming, Qin, Da Lian, Wu, An Guo. Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease[J]. Inflammation and Regeneration, 2022, 42(1).
Authors:  Zhou, Xiao Gang;  Qiu, Wen Qiao;  Yu, Lu;  Pan, Rong;  Teng, Jin Feng; et al.
Favorite | TC[WOS]:23 TC[Scopus]:23  IF:5.0/7.2 | Submit date：2023/01/30
Alzheimer’s Disease  Ampk/ulk1  Autophagy  Nlrp3 Inflammasome  Raf/mek/erk  Thonningianin a  
Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes Journal article
Zhao, Jiannan, Li, Yongling, Ma, Jing, Liu, Jingting, Xiao, Ruoxuan, Wang, Linlin, Li, Peng, He, Yinyan, Qian, Feng, Zhang, Ao, Sun, Zhen Liang, Ding, Chunyong. Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes[J]. European Journal of Medicinal Chemistry, 2022, 237, 114338.
Authors:  Zhao, Jiannan;  Li, Yongling;  Ma, Jing;  Liu, Jingting;  Xiao, Ruoxuan; et al.
Favorite | TC[WOS]:4 TC[Scopus]:5  IF:6.0/6.1 | Submit date：2022/05/13
Fluorescence Imaging  Inflammasome  Inhibitor  Nlrp3  Sulfonylurea