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Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
Xu,Biao, Wang,Zhi Peng, Liu,Qingwang, Yang,Xiaohong, Li,Xuemin, Huang,Ding, Qiu,Yanfei, Tam,Kin Yip, Zhang,Shao Lin, He,Yun. Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 214, 113225.
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin; et al.
Favorite | TC[WOS]:11 TC[Scopus]:11  IF:6.0/6.1 | Submit date：2021/03/04
Cancer Metabolism  Proliferation  Pyruvate Dehydrogenase Kinase  Structure-activity Relationship  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
Zhang,Shao Lin, Yang,Zheng, Hu,Xiaohui, Tam,Kin Yip. Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships[J]. Bioorganic and Medicinal Chemistry Letters, 2018, 28(21), 3441-3445.
Authors:  Zhang,Shao Lin;  Yang,Zheng;  Hu,Xiaohui;  Tam,Kin Yip
Favorite | TC[WOS]:17 TC[Scopus]:18  IF:2.5/2.4 | Submit date：2021/03/04
Antiproliferative Activity  Dichloroacetophenone  Kinase Inhibition  Pyruvate Dehydrogenase Complex  Pyruvate Dehydrogenase Kinase  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
Zhang, Shao-Lin, Yang, Zheng, Hu, Xiaohui, Tam, Kin Yip. Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28(21), 3441-3445.
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite | TC[WOS]:17 TC[Scopus]:18  IF:2.5/2.4 | Submit date：2018/10/30
Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Antiproliferative Activity  Dichloroacetophenone  Kinase Inhibition  
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
Zhang, Shao-Lin, Yang, Zheng, Hu, Xiaohui, Chakravarty, Harapriya, Tam, Kin Yip. Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 123, 43-55.
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite | TC[WOS]:15 TC[Scopus]:15  IF:4.3/4.2 | Submit date：2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming  
Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy Journal article
Chen, Lei-Lei, Wang, Yong-Bo, Song, Ju-Xian, Deng, Wan-Kun, Lu, Jia-Hong, Ma, Li-Li, Yang, Chuan-Bin, Li, Min, Xue, Yu. Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy[J]. AUTOPHAGY, 2017, 13(11), 1969-1980.
Authors:  Chen, Lei-Lei;  Wang, Yong-Bo;  Song, Ju-Xian;  Deng, Wan-Kun;  Lu, Jia-Hong; et al.
Favorite | TC[WOS]:37 TC[Scopus]:51  IF:14.6/16.8 | Submit date：2018/10/30
Autophagy  Corynoxine  Kinase Activity  Phosphoproteome  Phosphorylation  Protein Kinase  
Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells Journal article
Little P.J., Rostam M.A., Piva T.J., Getachew R., Kamato D., Guidone D., Ballinger M.L., Zheng W., Osman N.. Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells[J]. Journal of Pharmacy and Pharmacology, 2013, 65(7), 1055-1063.
Authors:  Little P.J.;  Rostam M.A.;  Piva T.J.;  Getachew R.;  Kamato D.; et al.
Favorite | TC[WOS]:15 TC[Scopus]:15 | Submit date：2018/12/21
Atherosclerosis  Biglycan  Imatinib  Pdgfβ Receptor Kinase Activity  Pdgfβ Receptor Phosphorylation