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Clofazimine pKa Determination by Potentiometry and Spectrophotometry: Reverse Cosolvent Dependence as an Indicator of the Presence of Dimers in Aqueous Solutions Journal article
Verbić, Tatjana Ž, Tam, Kin Y., Veljković, Dušan Ž, Serajuddin, Abu T.M., Avdeef, Alex. Clofazimine pKa Determination by Potentiometry and Spectrophotometry: Reverse Cosolvent Dependence as an Indicator of the Presence of Dimers in Aqueous Solutions[J]. Molecular Pharmaceutics, 2023, 20(6), 3160-3169.
Authors:  Verbić, Tatjana Ž;  Tam, Kin Y.;  Veljković, Dušan Ž;  Serajuddin, Abu T.M.;  Avdeef, Alex
Favorite | TC[WOS]:4 TC[Scopus]:5  IF:4.5/4.6 | Submit date：2023/07/20
Clofazimine  Density Functional Theory  Dimerization  Pka Value  Potentiometry  Principal Component Analysis  Uv/vis Spectrophotometry  
α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Chen, Jia Yue, Zhu, Qi, Cai, Cui Zan, Luo, Hai Bin, Lu, Jia Hong. α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation[J]. Phytomedicine, 2022, 101, 154125.
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite | TC[WOS]:8 TC[Scopus]:8  IF:6.7/6.2 | Submit date：2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
Decabromodiphenyl ether-induced PRKACA hypermethylation contributed to glycolipid metabolism disorder via regulating PKA/AMPK pathway in rat and L-02 cells Journal article
Zhu, Yupeng, Jing, Li, Li, Xiangyang, Zhou, Guiqing, Zhang, Yue, Sang, Yujian, Gao, Leqiang, Liu, Sitong, Shi, Zhixiong, Sun, Zhiwei, Ge, Wei, Zhou, Xianqing. Decabromodiphenyl ether-induced PRKACA hypermethylation contributed to glycolipid metabolism disorder via regulating PKA/AMPK pathway in rat and L-02 cells[J]. Environmental Toxicology and Pharmacology, 2022, 90(103808).
Authors:  Zhu, Yupeng;  Jing, Li;  Li, Xiangyang;  Zhou, Guiqing;  Zhang, Yue; et al.
Favorite | TC[WOS]:5 TC[Scopus]:5  IF:4.2/4.4 | Submit date：2022/03/04
Decabromodiphenyl Ether  Glycolipid Metabolism  Pka/ampk Signaling Pathway  Prkaca  Dna Hypermethylation  
β-Patchoulene Ameliorates Water Transport and the Mucus Barrier in 5-Fluorouracil-Induced Intestinal Mucositis Rats via the cAMP/PKA/CREB Signaling Pathway Journal article
Wu, Jiazhen, Gan, Yuxuan, Luo, Huijuan, Xu, Nan, Chen, Liping, Li, Mengyao, Guan, Fengkun, Su, Ziren, Lin, Zhixiu, Xie, Jianhui, Liu, Yuhong. β-Patchoulene Ameliorates Water Transport and the Mucus Barrier in 5-Fluorouracil-Induced Intestinal Mucositis Rats via the cAMP/PKA/CREB Signaling Pathway[J]. Frontiers in Pharmacology, 2021, 12, 689491.
Authors:  Wu, Jiazhen;  Gan, Yuxuan;  Luo, Huijuan;  Xu, Nan;  Chen, Liping; et al.
Favorite | TC[WOS]:15 TC[Scopus]:16  IF:4.4/5.0 | Submit date：2021/12/08
5-fluorouracil  Camp/pka/creb Pathway  Intestinal Mucositis  Water Transport  Β--patchoulene  
Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models Journal article
Zhu, Qi, Zhuang, Xu xu, Chen, Jia yue, Yuan, Ning ning, Chen, Yan, Cai, Cui zan, Tan, Jie qiong, Su, Huan xing, Lu, Jia hong. Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models[J]. Phytomedicine, 2021, 87, 153578.
Authors:  Zhu, Qi;  Zhuang, Xu xu;  Chen, Jia yue;  Yuan, Ning ning;  Chen, Yan; et al.
Favorite | TC[WOS]:17 TC[Scopus]:18  IF:6.7/6.2 | Submit date：2021/12/08
Camp/pka Pathway  Lycorine  Parkinson's Disease  Ubiquitin-proteasome System  Α-synuclein  
Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth Journal article
Deng, Zhiqiang, Li, Xianting, Ramirez, Marian Blanca, Purtell, Kerry, Choi, Insup, Lu, Jia Hong, Yu, Qin, Yue, Zhenyu. Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth[J]. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118(14), e2020215118.
Authors:  Deng, Zhiqiang;  Li, Xianting;  Ramirez, Marian Blanca;  Purtell, Kerry;  Choi, Insup; et al.
Favorite | TC[WOS]:26 TC[Scopus]:29  IF:9.4/10.8 | Submit date：2021/12/07
Akap11  Autophagy  Cell Survival  Mitochondrial Metabolism  Pka  
A cucurbit[8]uril 2:2 complex with a negative pKa shift Journal article
Hang Yin, Qian Cheng, Roselyne Rosas, Stéphane Viel, Valérie Monnier, Laurence Charles, Didier Siri, Didier Gigmes, Olivier Ouari, Ruibing Wang, Anthony Kermagoret, David Bardelang. A cucurbit[8]uril 2:2 complex with a negative pKa shift[J]. CHEMISTRY-A EUROPEAN JOURNAL, 2019, 12552-12559.
Authors:  Hang Yin;  Qian Cheng;  Roselyne Rosas;  Stéphane Viel;  Valérie Monnier; et al.
Favorite | TC[WOS]:21 TC[Scopus]:21  IF:3.9/4.1 | Submit date：2022/07/27
Cucurbit[8]Uril  2:2 Complex  Negative Pka Shift  
Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization Journal article
Chuwen Li, Yaqi Bian, Yu Feng, Fan Tang, Liang Wang, Maggie Pui Man Hoi, Dan Ma, Chao Zhao, Simon Ming Yuen Lee. Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization[J]. ACS CHEMICAL NEUROSCIENCE, 2019, 10(5), 2434-2449.
Authors:  Chuwen Li;  Yaqi Bian;  Yu Feng;  Fan Tang;  Liang Wang; et al.
Favorite | TC[WOS]:24 TC[Scopus]:26  IF:4.1/4.3 | Submit date：2020/01/16
Bhdpc  Ischemic Stroke  Microglia  Nf-κb  Creb  Pka  
Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology Journal article
Ning-Ning Yuan, Cui-Zan Cai, Ming-Yue Wu, Qi Zhu, HuanXing Su, Min Li, JiaoYan Ren, Jie-Qiong Tan, Jia-Hong Lu. Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology[J]. FRONTIERS IN PHARMACOLOGY, 2019, 10.
Authors:  Ning-Ning Yuan;  Cui-Zan Cai;  Ming-Yue Wu;  Qi Zhu;  HuanXing Su; et al.
Favorite | TC[WOS]:18 TC[Scopus]:20  IF:4.4/5.0 | Submit date：2020/04/14
Canthin-6-one  Parkinson’s Disease  Alpha-synuclein  Ubiquitin-proteasome-system  Crispr/cas9  Rpn2/psmd1  Pka  
BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-κB and activating PKA/CREB Journal article
Chuwen Li, Tongkai Chen, Hefeng Zhou, Yu Feng, Maggie P. M. Hoi, Dan Ma, Chao Zhao, Ying Zheng, Simon M. Y. Lee. BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-κB and activating PKA/CREB[J]. Frontiers in Pharmacology, 2018, 9(JUN).
Authors:  Chuwen Li;  Tongkai Chen;  Hefeng Zhou;  Yu Feng;  Maggie P. M. Hoi; et al.
Favorite | TC[WOS]:19 TC[Scopus]:22 | Submit date：2018/11/06
Bhdpc  Creb  Microglia  Neuroinflammation  Nf-κb  Pka