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Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway Journal article
Chong, Cheong Meng, Tan, Yuan, Tong, Jiaqi, Ke, Minjing, Zhang, Ke, Yan, Lingli, Cen, Xiaotong, Lu, Jia Hong, Chen, Guobing, Su, Huanxing, Qin, Dajiang. Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway[J]. Cell and Bioscience, 2022, 12(1), 131.
Authors:  Chong, Cheong Meng;  Tan, Yuan;  Tong, Jiaqi;  Ke, Minjing;  Zhang, Ke; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:6.1/7.0 | Submit date：2023/01/30
Mtor  Presenilin-1  Ipsc  Crispr/cas9  
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease Journal article
Tong, Benjamin Chun Kit, Wu, Aston Jiaxi, Huang, Alexis Shiying, Dong, Rui, Malampati, Sandeep, Iyaswamy, Ashok, Krishnamoorthi, Senthilkumar, Sreenivasmurthy, Sravan Gopalkrishnashetty, Zhu, Zhou, Su, Chengfu, Liu, Jia, Song, Juxian, Lu, Jia Hong, Tan, Jieqiong, Pan, Weidong, Li, Min, Cheung, King Ho. Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease[J]. Autophagy, 2021, 18(3), 624-642.
Authors:  Tong, Benjamin Chun Kit;  Wu, Aston Jiaxi;  Huang, Alexis Shiying;  Dong, Rui;  Malampati, Sandeep; et al.
Favorite | TC[WOS]:30 TC[Scopus]:30  IF:14.6/16.8 | Submit date：2022/05/17
Alzheimer Disease  Autophagy-lysosomal Pathway  Calcium Ion  Presenilin-1  Two Pore Segment Channel 2