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Probing the AFF4–CCNT1 protein–protein interaction using a metal–organic conjugate for treating triple-negative breast cancer Journal article
Song, Ying Qi, Xu, Yiwen, Yang, Li Jun, Wang, Ling, Jing, Shaozhen, Yang, Guan Jun, Shiu-Hin Chan, Daniel, Wong, Chun Yuen, Wang, Wanhe, Kam Wai Wong, Vincent, Leung, Chung Hang. Probing the AFF4–CCNT1 protein–protein interaction using a metal–organic conjugate for treating triple-negative breast cancer[J]. Chemical Engineering Journal, 2024, 496, 153685.
Authors:  Song, Ying Qi;  Xu, Yiwen;  Yang, Li Jun;  Wang, Ling;  Jing, Shaozhen; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:13.3/13.2 | Submit date：2024/08/05
Aff4  Ccnt1  Metal–organic Conjugate  Protein–protein Interaction  Triple-negative Breast Cancer  
Molecular Modulators and Receptors of Selective Autophagy: Disease Implication and Identification Strategies Review article
2024
Authors:  Wu, Ming Yue;  Li, Zhe Wei;  Lu, Jia Hong
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:8.2/8.3 | Submit date：2024/05/16
Autophagy  Genome-wide Screening  Protein-protein Interaction  Screening Technology  Selective Autophagy  
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer Journal article
Jiang, Qiwei, Li, Yong, Cai, Songwang, Shi, Xingyuan, Yang, Yang, Xing, Zihao, He, Zhenjie, Wang, Shengte, Su, Yubin, Chen, Meiwan, Chen, Zhesheng, Shi, Zhi. GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer[J]. Acta Pharmaceutica Sinica B, 2023, 14(2), 698-711.
Authors:  Jiang, Qiwei;  Li, Yong;  Cai, Songwang;  Shi, Xingyuan;  Yang, Yang; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:14.7/14.1 | Submit date：2024/02/22
Enzyme  Gastric Cancer  Glul  N-cadherin  Protein Stability  Protein-protein Interaction  Ubiquitination  Β-catenin  
Dehydroeburicoic Acid, a Dual Inhibitor against Oxidative Stress in Alcoholic Liver Disease Journal article
Shasha Cheng, Yi Kuang, Guodong Li, Jia Wu, Chung-Nga Ko, Wanhe Wang, Dik-Lung Ma, Min Ye, Chung-Hang Leung. Dehydroeburicoic Acid, a Dual Inhibitor against Oxidative Stress in Alcoholic Liver Disease[J]. Pharmaceuticals, 2022, 16(1), 14.
Authors:  Shasha Cheng;  Yi Kuang;  Guodong Li;  Jia Wu;  Chung-Nga Ko; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:4.3/4.6 | Submit date：2023/02/08
Alcoholic Liver Disease (Ald)  Glycogen Synthase Kinase 3β (Gsk3β)  Hepatoprotective  Keap1–nrf2 Protein–protein Interaction (Ppi)  
Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer Journal article
Cheng, Sha Sha, Qu, Yuan Qing, Wu, Jia, Yang, Guan Jun, Liu, Hao, Wang, Wanhe, Huang, Qi, Chen, Feng, Li, Guodong, Wong, Chun Yuen, Wong, Vincent Kam Wai, Ma, Dik Lung, Leung, Chung Hang. Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer[J]. Acta Pharmaceutica Sinica B, 2022, 12(3), 1390-1405.
Authors:  Cheng, Sha Sha;  Qu, Yuan Qing;  Wu, Jia;  Yang, Guan Jun;  Liu, Hao; et al.
Favorite | TC[WOS]:36 TC[Scopus]:39  IF:14.7/14.1 | Submit date：2022/04/06
Epigenetics  Kinase Inhibitor  Metal Complex  Metastasis  Protein–protein Interaction  Triple-negative Breast Cancer  
An optimized BRD4 inhibitor effectively eliminates NF-κB-driven triple-negative breast cancer cells Journal article
Yang, Guan Jun, Song, Ying Qi, Wang, Wanhe, Han, Quan Bin, Ma, Dik Lung, Leung, Chung Hang. An optimized BRD4 inhibitor effectively eliminates NF-κB-driven triple-negative breast cancer cells[J]. BIOORGANIC CHEMISTRY, 2021, 114, 105158.
Authors:  Yang, Guan Jun;  Song, Ying Qi;  Wang, Wanhe;  Han, Quan Bin;  Ma, Dik Lung; et al.
Favorite | TC[WOS]:29 TC[Scopus]:30  IF:4.5/4.7 | Submit date：2021/12/08
Acetylated Rela  Brd4  Nf-κb  Protein-protein Interaction  Tnbc  
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells Journal article
Shasha Cheng, Guan-Jun Yang, Wanhe Wang, Dik-Lung Ma, Chung-Hang Leung. Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells[J]. Genes & Diseases, 2021, 9(6), 1674-1688.
Authors:  Shasha Cheng;  Guan-Jun Yang;  Wanhe Wang;  Dik-Lung Ma;  Chung-Hang Leung
Favorite | TC[WOS]:23 TC[Scopus]:26  IF:6.9/7.2 | Submit date：2022/05/13
Cancer Stem Cells  Cdk9-cyclin T1  Epithelial Mesenchymal Transition  Protein–protein Interaction (Ppi)  Triple-negative Breast Cancer (Tnbc)  
A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy Journal article
Yang,Guan Jun, Wang,Wanhe, Lei,Pui Man, Leung,Chung Hang, Ma,Dik Lung. A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy[J]. International Journal of Biological Macromolecules, 2020, 164, 3204-3220.
Authors:  Yang,Guan Jun;  Wang,Wanhe;  Lei,Pui Man;  Leung,Chung Hang;  Ma,Dik Lung
Favorite | TC[WOS]:26 TC[Scopus]:26  IF:7.7/7.7 | Submit date：2021/03/01
Brd4  BromoDomain Domain  Cell Metastasis And Invasion  Histone Acetylation  Melanoma  Protein–protein Interaction  Virtual Screening  
The design and development of covalent protein-protein interaction inhibitors for cancer treatment Review article
2020
Authors:  Cheng,Sha Sha;  Yang,Guan Jun;  Wang,Wanhe;  Leung,Chung Hang;  Ma,Dik Lung
Favorite | TC[WOS]:60 TC[Scopus]:65  IF:29.5/26.9 | Submit date：2021/03/01
Cancer Therapy  Covalent Inhibitors  Protein-protein Interaction  
Emerging Screening Approaches in the Development of Nrf2-Keap1 Protein-Protein Interaction Inhibitors Review article
2019
Authors:  Leung, CH;  Zhang, JT;  Yang, GJ;  Liu, H;  Han, QB; et al.
Favorite | TC[WOS]:42 TC[Scopus]:45 | Submit date：2020/03/23
Virtual Screening  Keap1-nrf2  Protein-protein Interaction  Inhibitors  Oxidative Stress