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A NIR iridium(III) complex-based luminescence probe for imaging mitochondria pyruvate dehydrogenase kinase 1 in triple-negative breast cancer cells Journal article
Jing, Shaozhen, Song, Ying Qi, Liu, Jingqi, Zhao, Chen, Wang, Ling, Chan, Daniel Shiu Hin, Wong, Chun Yuen, Lee, Simon Ming Yuen, Wang, Jing, Leung, Chung Hang, Wang, Wanhe. A NIR iridium(III) complex-based luminescence probe for imaging mitochondria pyruvate dehydrogenase kinase 1 in triple-negative breast cancer cells[J]. Sensors and Actuators B: Chemical, 2024, 418, 136265.
Authors:  Jing, Shaozhen;  Song, Ying Qi;  Liu, Jingqi;  Zhao, Chen;  Wang, Ling; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:8.0/7.0 | Submit date：2024/08/05
Breast Cancer  Dichloroacetic Acid (Dca)  Iridium(Iii) Complex  Mitochondrial Targeting  Nir Imaging  Pyruvate Dehydrogenase Kinase 1 (Pdk1)  
Dichloroacetophenone derivatives as pyruvate dehydrogenase kinase inhibitor in non-small cell lung cancer models Presentation
会议地点: University Rectorate, Belgrade, Serbia, 会议日期: 4-6 September, 2023, 报告日期: 2023-09-05
Authors:  TAM KIN YIP
Favorite |  | Submit date：2024/08/30
Cancer Metabolism  Aerobic Glycolysis  Pyruvate Dehydrogenase Kinase  
Targeting glucose metabolism to develop anticancer treatments and therapeutic patents Review article
2022
Authors:  Zhou, Yan;  Guo, Yizhen;  Tam, Kin Yip
Favorite | TC[WOS]:22 TC[Scopus]:21  IF:5.4/6.4 | Submit date：2022/05/17
Cancer Glucose Metabolism  Cancer Treatment Patent  Glycolytic Inhibitor  Hexokinase 2 (Hk2)  Lactate Dehydrogenase a (Ldha)  Pyruvate Dehydrogenase Kinase (Pdk)  Warburg Effect  
Vibrio alginolyticus Survives From Ofloxacin Stress by Metabolic Adjustment Journal article
Yin, Yue, Yin, Yuanpan, Yang, Hao, Chen, Zhuanggui, Zheng, Jun, Peng, Bo. Vibrio alginolyticus Survives From Ofloxacin Stress by Metabolic Adjustment[J]. Frontiers in Microbiology, 2022, 13, 818923.
Authors:  Yin, Yue;  Yin, Yuanpan;  Yang, Hao;  Chen, Zhuanggui;  Zheng, Jun; et al.
Favorite | TC[WOS]:14 TC[Scopus]:15  IF:4.0/5.1 | Submit date：2022/05/13
Fatty Acid Synthesis  Metabolomics  Ofloxacin  Pyruvate Cycle  Vibrio Alginolyticus  
Targeting glucose metabolism to develop anticancer treatments and therapeutic patents Journal article
Zhou Yan, Guo Yizhen, TAM KIN YIP. Targeting glucose metabolism to develop anticancer treatments and therapeutic patents[J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 2022, 32(4), 441-453.
Authors:  Zhou Yan;  Guo Yizhen;  TAM KIN YIP
Adobe PDF | Favorite | TC[WOS]:22 TC[Scopus]:21  IF:5.4/6.4 | Submit date：2024/08/29
Cancer Treatment Patent  Cancer Glucose Metabolism  Warburg Effect  Hexokinase 2 (Hk2)  Pyruvate Dehydrogenase Kinase (Pdk)  Lactate Dehydrogenase a (Ldha)  Glycolytic Inhibitor  
A review on the emerging roles of pyruvate kinase M2 in anti-leukemia therapy Review article
2021
Authors:  Yang, Guan Jun;  Wu, Jia;  Leung, Chung Hang;  Ma, Dik Lung;  Chen, Jiong
Favorite | TC[WOS]:16 TC[Scopus]:16  IF:7.7/7.7 | Submit date：2022/01/14
Leukemia  Modulators  Pyruvate Kinase M2  
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
Xu,Biao, Wang,Zhi Peng, Liu,Qingwang, Yang,Xiaohong, Li,Xuemin, Huang,Ding, Qiu,Yanfei, Tam,Kin Yip, Zhang,Shao Lin, He,Yun. Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 214, 113225.
Authors:  Xu,Biao;  Wang,Zhi Peng;  Liu,Qingwang;  Yang,Xiaohong;  Li,Xuemin; et al.
Favorite | TC[WOS]:10 TC[Scopus]:9  IF:6.0/6.1 | Submit date：2021/03/04
Cancer Metabolism  Proliferation  Pyruvate Dehydrogenase Kinase  Structure-activity Relationship  
Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation Journal article
Xiang,Sichuan, Huang,Ding, He,Qiaolin, Li,Jie, Tam,Kin Yip, Zhang,Shao Lin, He,Yun. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 203, 112579.
Authors:  Xiang,Sichuan;  Huang,Ding;  He,Qiaolin;  Li,Jie;  Tam,Kin Yip; et al.
Favorite | TC[WOS]:13 TC[Scopus]:14  IF:6.0/6.1 | Submit date：2021/03/04
Cancer Metabolism  Cancer Proliferation  Dual Inhibitor  Lactate Dehydrogenase a  Pyruvate Dehydrogenase Kinase  
LC/MS/MS method revealed that lung cancer cells exhibited distinct metabolite profiles upon the treatment with different anticancer pyruvate dehydrogenase kinases (PDKs) inhibitors Presentation
会议地点: Hotel Park, Split, Croatia, 会议日期: 9-11 September 2019, 报告日期: 2019-09-09
Authors:  TAM KIN YIP
Favorite |  | Submit date：2024/08/30
Aerobic Glycolysis  Lc-ms/ms  Pyruvate Dehydrogenase Kinases  Cancer Metabolism  
Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells Journal article
Chengcheng Song, Faxiang Xu, Zhili Ren, Yumeng Zhang, Ya Meng, Yiqi Yang, Shreyas Lingadahalli, Edwin Cheung, Gang Li, Weiwei Liu, Jianbo Wan, Yang Zhao, Guokai Chen. Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells[J]. STEM CELL REPORTS, 2019, 13(2), 338-351.
Authors:  Chengcheng Song;  Faxiang Xu;  Zhili Ren;  Yumeng Zhang;  Ya Meng; et al.
Favorite | TC[WOS]:29 TC[Scopus]:34  IF:5.9/5.9 | Submit date：2020/04/22
Hescs  Pyruvate  Bmp4  Glycolysis  Tca Cycle  Ampk  Wnt  Metabolism  Mesoderm  Differentiation